How many of us have family members with lupus?

New Topic Post Reply Printable Version
[ << Previous Thread | Next Thread >> ]

CNSKris
Regular Member


Date Joined May 2006
Total Posts : 236
   Posted 8/24/2007 7:55 AM (GMT -7)   
I was curious to know if others in the forum had family members with connective tissue disease and if so, did they have the DNA for it.  My mother's side are lupus carriers: great-grandfather, cousin, myself and my daughter.  I do not have the DNA marker for it.  This is very confusing to me.  If you don't mind my asking, I would like to know your views on this topic.
 
Thank you all - Hugs - Kristin
 
  Dx:  Lupus CNS 11/2005; Current - kidney disease, enlarged heart, MVP/regurg, dementia; GERD; vision loss, narcolepsy, rheumatic arthritis, IBS, ovarian cysts, raynauds, EBV/CFS, inflam. liver/spleen. Rx:  Atenolol, Aricept, Flexeril, Motrin  Previous-rashes, hemi-pelagic migraine, sensory loss, amnesia, PTSD/Dep., host of neuro problems, pregnancy compl., False pos. syphilis, fine speck & homogen ANA; IgM; staph/strept infections, colonitis, pancreaitis, gastritis, costochondritis, pericarditis, Hashimoto's, dyspnea, hyper/hypotension, lipedemia, ulcers, pneumonia, anemia, Scleroderma symptoms, vein swelling, etc.  
 
 


katykat
Regular Member


Date Joined Jan 2007
Total Posts : 34
   Posted 8/24/2007 8:04 AM (GMT -7)   
Hi Kristin,

The only family member I know of that had lupus was my mom. She also had rheumatic fever as a child. I don't know if they are connected. I don't know if she had the DNA of it because she passed away in 1986. So far my daughter has no signs of it.

Take care,

Denise
dx - sle 2001, fibro 2006, depression


dbab
Veteran Member


Date Joined Jan 2004
Total Posts : 4151
   Posted 8/24/2007 8:04 AM (GMT -7)   
Well I'm not sure of the DNA marker but I know that I have 3 family members with Lupus history and a couple more with rheumatic diseases.

My aunt (mom's sister) died from lung complications from Lupus when I was really young. I actually did not know that it was Lupus or maybe I did and it didn't click, but I didn't realize that she had Lupus until I was diagnosed. I knew she died from lung complications didn't know why at the time, very sensitive subject. Because of this, my grandmother took the news about me extremely hard. I also have two cousins on my mom's side that have Lupus.

My dad's side has rheumatoid arthritis. My grandmother had it since she was in her 40's and my cousin on my dad's side has it too (she is 39).
"Des"
Co-Moderator ~ IBS Forum
Co-Moderator ~ Lupus Forum 
Dx: IBS 1989, Diverticulosis 2004, Idiopathic Acute Colitis 2006, UCTD 2007
Meds: Plaquenil 400mg, Chlorzoxazone 500mg, Lyrica 50mg, Protonix 40mg, Naproxen 1000mg, Klonopin PRN, Miralax 17g, Supplements


http://www.healingwell.com/donate


applesk82
Regular Member


Date Joined Oct 2003
Total Posts : 262
   Posted 8/24/2007 8:56 AM (GMT -7)   
i'm not sure about DNA markers and all that my family has never been tested, but so far i am the only person in my family that has been diagnosed with lupus.
Hugs and prayers,
~Suzanne~
 
diagnosed in May '95 with lupus nephritis, hypertension,hypothyroidism, avascular necrosis (knee) '98, kidney transplant April '06, pseudo-cerebral tumor '07
prednisone, cellcept, prograf, lopressor, allopurinol, synthroid, diamox, OsCal +D, lunesta, celexa, percocet for pain


PattyLatty
Veteran Member


Date Joined Mar 2006
Total Posts : 2570
   Posted 8/24/2007 9:19 AM (GMT -7)   
My mother had lupus. She died a year and a half ago from heart disease, not lupus. My 20 year old daughter has a positive ANA and raynaud's but no other symptoms and I pray she never gets lupus. She's as healthy as can be.

I don't know if any of us has the DNA marker. I have heard that lupus is passed on by the mother but that may be an old wife's tale. Do any of you know differently?
Lupus, Rheumatoid Arthritis, Sjogren's, osteoarthritis, fibro, ibs, renauds, restless leg, hiatal hernia, double vision, migraines.
cellcept, neurontin, prednisone, plaquenil, synthroid, triamterene, tramadol, actonel, tri-est, imitrex, cymbalta, multivitamin, calcium w vit D, fish oil, aspirin


Lynnwood
Forum Moderator


Date Joined May 2005
Total Posts : 7018
   Posted 8/24/2007 11:06 AM (GMT -7)   
No lupus, but my paternal grandfather had a rather bad case of RA -- another autoimmune problem.

Lynnwood, Co-Moderator: Lupus Forum
SLE(’00), Sjogren's Syndrome, SAD, Depression, Herpes Simplex 1
Piroxicam, Plaquenil, Cellcept, Prednisone, Trazodone, Fosamax, Wellbrutrin SR, Valtrex
Links: DIAGNOSING LUPUS(4of11), LUPUS INFORMATION, LUPUS RESOURCES, Donate to HealingWell, Drug Interactions


hippimom2
Veteran Member


Date Joined Jul 2005
Total Posts : 5403
   Posted 8/24/2007 11:54 AM (GMT -7)   
My dad's sister has lupus and there are a whole slew of people on my mom's side of the family with RA. My son (9) has juvenile arthritis and also very well might have had rheumatic fever. Docs are still trying to figure out his case. They now think that he might have a reactive arthritis due to rheumatic fever but that he may also have an underlying connective tissue disease since he has a positive ANA and always has an elevated sed rate. So far my daughter (5) is healthy, but I worry everytime she complains of fatigue or growing pains.
Diagnosis:  UCTD (lupus) 2006; Raynauds 2006; Sjogren's 2006; lupus symptoms began 2003; CFS 1991; Mono 1985
Meds:  Plaquenil 400mg; Prednisone 5-10mg; Tramadol 100mg 3-4x daily; Doxepin 25-50mg; Prevacid; Steriod Cream and Mouth Rinse for tongue and mouth ulcers; Hydrocodone 5/500 prn for severe pain; Artificial tears

 

Clickable:  LUPUS INFORMATION & LUPUS RESOURCES.

Please allow HealingWell to continue helping others by donating: http://www.healingwell.com/donate/

 

Co-Moderator: Lupus and CFS Forums



curlyhair
Veteran Member


Date Joined Jan 2005
Total Posts : 659
   Posted 8/24/2007 4:27 PM (GMT -7)   

I am the only one is my family with kidney disease, lupus, and an eating disorder. Everyone else is healthy and normal!

Sandy


DX: Kidney Disease, (? Lupus Nephritis) 2002
DX: Raynaud's Phenomenon and Lupus 2005
DX: Anorexia and Hypokalemia 2006
 
meds: plaquenil, lasix, klor-con


mom46
Veteran Member


Date Joined Dec 2004
Total Posts : 8198
   Posted 8/24/2007 5:13 PM (GMT -7)   

 I had two cousins on my dad's side of the family with lupus. My mom's side was mostly heart disease, cancer and diabeties. As far as I know, I'm the only living member of either side with lupus now.

                                                                   Babs


 
 Lupus,RLS,RA,Asthma,Fibro,Sjogren's,Raynaud's,Divertic, Stroke,Atherosclerosis,Seizures,Sensory Polyneuropathy
Meds:Arava,plavix,aspirin,protonix,gabitril,zanaflex,xanax,
mirapex,advair,foxamax,donnatal,folic acid.
 
JOB 5:18 For he wounds, but he also binds up; he injures, but his hands also heal.


Audrey Ann
Veteran Member


Date Joined Jul 2005
Total Posts : 815
   Posted 8/24/2007 8:19 PM (GMT -7)   
I am not sure about the DNA markers for any of us but my grandmother had very bad RA, I have lupus and RA, my neice has lupus, and my mom has most of the lupus symptoms but she won't follow through with a visit to a rhuemy (VERY maddening but she is very stubborn and has emphysema so she is always going to the doctor). My rhuemy suspects my grandmother might have had lupus, too, but that it went undiagnosed at that time in medicine.
Audrey Ann
Diagnosis: Lupus and RA
Medications: Plaquenil (400 mg), RelafenMethotrexate Injections, Folic Acid, Aldactizide for High Blood Pressure, Lipitor for High Cholesterol, Actonel for Osteopenia, and Allegra & Patonel Eye Drops for Allergies.


 


cured4real?
Veteran Member


Date Joined Dec 2005
Total Posts : 1944
   Posted 8/24/2007 9:00 PM (GMT -7)   
Hi Kristin,
I don't have the dna markers for it either. My rheumatologist thinks either my ai condition is secondary to another disease or I'm just working up to it. I read an article recently where the daughter of a woman with lupus was diagnosed with lupus with no markers and later in life developed the dna markers, so I guess it can happen that way.

As for family, my maternal grandfather had rheumatoid arthritis, my mom I think has a problem but wont get the docs to test her, she has numerous allergies and health problems, my paternal side of the family all have fatty liver disease with other AI conditions, my cousin has big lumps all over his body like sarcoidosis but was never diagnosed, my paternal grandmother had ai problems, but they were attributed to her liver disease, as are my dad's. Its obvious we have some type of genetic ai related disorder, but it seems to vary in each paternal family member.

My doc thinks I'm just coming in to my AI disease, just starting to get it, so he suspects that eventually the tests will become more clear. I just have speckled ANA. I do have tough skin and lots of scar tissue like under it. I've asked about it and he said something about mild scleroderma, but I didn't have the test results he wanted to see for that.

I hope you are feeling well and that this helps in some way!
Love, Marji
--Doctors are men who prescribe medicines of which they know little, to cure diseases of which they know less in human beings of whom they know nothing.--Voltaire (1694-1778)
Ills--Sjogrens-Lupus-like AI Disease, Hashis, Vitiligo, spinal stenosis/fusion with plate, salivary/lymphectomies, Diabetes, NAFLD, COPD, RLS, neuropathy, trigonitis, hystero, diffuse brain atrophy
Meds--Plaquenil, Evoxac, Metformin, Synthroid, HCTZ, Estradiol patch, Prosed, Klonopin, Soma, Ultram, Vicodin, Restasis, Albuterol,steroid injections, Protopic & Triamcinolone Acetonide ointments


CNSKris
Regular Member


Date Joined May 2006
Total Posts : 236
   Posted 8/25/2007 4:06 PM (GMT -7)   
Thank you everyone. I realize these are personal questions and really appreciate your respnses. This is one strange disease. I am amazed at how many do have family members with it, yet many without a family history. I am now less concerned about the DNA marker since so many do not have it and still have famial histories of lupus.

I love everyone here - you are all such wonderful, caring, courageous people. I am very proud to be a part of such a group - Hugs - Kristin
 
  Dx:  Lupus CNS 11/2005; Current - kidney disease, enlarged heart, MVP/regurg, dementia; GERD; vision loss, narcolepsy, rheumatic arthritis, IBS, ovarian cysts, raynauds, EBV/CFS, inflam. liver/spleen. Rx:  Atenolol, Aricept, Flexeril, Motrin  Previous-rashes, hemi-pelagic migraine, sensory loss, amnesia, PTSD/Dep., host of neuro problems, pregnancy compl., False pos. syphilis, fine speck & homogen ANA; IgM; staph/strept infections, colonitis, pancreaitis, gastritis, costochondritis, pericarditis, Hashimoto's, dyspnea, hyper/hypotension, lipedemia, ulcers, pneumonia, anemia, Scleroderma symptoms, vein swelling, etc.  
 
 


cured4real?
Veteran Member


Date Joined Dec 2005
Total Posts : 1944
   Posted 8/25/2007 9:18 PM (GMT -7)   
Hi Kristin--
I was mistakenly treated with alpha-interferon (a very powerful immune booster) and had AI problems, so it made them worse. Alpha interferon, a substance found in our bodies that helps to fight infection (a cytokine) causes the production of ds-dna. They can create lupus in rats in the lab. There is also something called antiinterferon, an antibody to it that may someday be used as a treatment for lupus. It seems like if they know interferon causes dsdna and lupus, they should be able to treat it with the appropriate drugs.
Love, Marji
--Doctors are men who prescribe medicines of which they know little, to cure diseases of which they know less in human beings of whom they know nothing.--Voltaire (1694-1778)
Ills--Sjogrens-Lupus-like AI Disease, Hashis, Vitiligo, spinal stenosis/fusion with plate, salivary/lymphectomies, Diabetes, NAFLD, COPD, RLS, neuropathy, trigonitis, hystero, diffuse brain atrophy
Meds--Plaquenil, Evoxac, Metformin, Synthroid, HCTZ, Estradiol patch, Prosed, Klonopin, Soma, Ultram, Vicodin, Restasis, Albuterol,steroid injections, Protopic & Triamcinolone Acetonide ointments


redrose77
Veteran Member


Date Joined Sep 2005
Total Posts : 2573
   Posted 8/25/2007 10:20 PM (GMT -7)   
I have several and also those with fibro, MCTD, UCTD, and other AI diseases.

My family is full of AI and cancer so it is not a suprise I ended up with something.
Dx:fibromyalgia 2002, systematic lupus 2005, psoriasis 2006, rheumetoid arthritis 2006, early sjogrens 2006, low positive anti-phospholipid antibodies/lupus anti-coglutant 2001-2004 and 2007, osteoarthritis 2005, Migraine 1994, Compression fracture 2001, Disk problems 2006, Multiple allergies 2006, Post traumatic stress disorder (PTSD) 2007, Bipolar type II 2007, possible siezures 2005, probable lupus CNS involvement 2007

Tx: plaquenil, Imuran, Enbrel, Celebrex, Tramadol, Norco, Singulair, Skelaxin, Evoxac, Clonazepam, Zonisamide, Baby Asprin, Relpax, Copper IUD


sharentrials
Regular Member


Date Joined Jul 2007
Total Posts : 261
   Posted 8/26/2007 5:29 PM (GMT -7)   
Hi, Kristen. I don't know anything about those markers you speak of, but my father does have Crohn's disease which is also an AI disease. I figure that's where my defective gene came from to predispose me to this lupus. No one else in my family is affected.
Always looking for the silver lining, Sharen

SLE '06, Sjogren's '06, Traumatic Head Injury '94
Prednisone 10mg and tapering, Caltrate 1200mg, Multi-vitamin, Prevacid 30 mg, Actonel 35mg


Bsime
Veteran Member


Date Joined Apr 2006
Total Posts : 1298
   Posted 8/26/2007 7:56 PM (GMT -7)   
Did not think that the dna patterns associated with AI diseases had been identified.  AI diseases tend to run in families but not necessarily the same ones.  Given what is known about AI that would make sense.  An immune system that is genetically susceptible to disruption or weakness.  Something comes along in life that triggers an attack.  That trigger would vary from individual to individual even with a similar genetic makeup.  Lupus in one case and something else in another.
 
I have mctd and so does my youngest sister.  There was no evidence of AI disease in our family with anyone so it seems like we are the groundbreakers.  She has had a life of substance abuse and I have lived a pretty healthy and moderate life...so figure that out.  2 siblings in the same generation with the same disease but nothing in common otherwise.
 
In the next 20 years there will be a better understanding of AI diseases on a cellular and even dna level.  My guess is that very specific treatments will start appearing within 10 years.  Probably too late for me but great for you youngsters.
 
Bill
Mixed connective tissue disease (systemic lupus, scleroderma, polymyositis), Raynauds phenomena, Hypertension, Barrett's esophagus.
 
Meds: prednisone (6mg & tapering), 75mg imuran, lisinopril 40mg, maxide 37.5/25mg, norvasc 5 mg, folic acid, potassium, aciphex 20mg, multi vitamins.
 
Maintain your optimism and you can beat the odds.
 
"Although the world is full of suffering, it is also full of the overcoming of it."  Helen Keller
 
 


emmi
Veteran Member


Date Joined Apr 2005
Total Posts : 1529
   Posted 8/26/2007 10:14 PM (GMT -7)   
My aunt (in her late 70s) has RA; my sister had Graves disease (an AI thyroid disease); our youngest daughter (27) has Hashimoto's thyroid disease; I have my menu of AI diseases. So that covers 3 generations in our family.

Bill, I hope you are right that specific treatments are on the horizon for our kids and beyond that my hope is cures for all future generations.

emmie
</FONT>

SLE, limited scleroderma, Sjogrens, Hashimoto's Thyroiditis, seizure disorder, Raynauds, Hashimoto's (or Autoimmune) Enchephalopathy


gloryroad
Regular Member


Date Joined Oct 2006
Total Posts : 193
   Posted 8/27/2007 5:55 AM (GMT -7)   
My maternal aunt and my paternal 1st cousin both have lupus. My father has RA.
Gloryroad


CNSKris
Regular Member


Date Joined May 2006
Total Posts : 236
   Posted 8/27/2007 7:45 AM (GMT -7)   
Wow, starting to get a visual pattern here. It doesn't seem genetic specific to lupus, but AI more so. A lot of cancer in my family too. Also, always wondered if there was a link with the cancer, but I'll torture you all with that another day :) - Thanks again - Kristin
 
  Dx:  Lupus CNS 11/2005; Current - kidney disease, enlarged heart, MVP/regurg, dementia; GERD; vision loss, narcolepsy, rheumatic arthritis, IBS, ovarian cysts, raynauds, EBV/CFS, inflam. liver/spleen. Rx:  Atenolol, Aricept, Flexeril, Motrin  Previous-rashes, hemi-pelagic migraine, sensory loss, amnesia, PTSD/Dep., host of neuro problems, pregnancy compl., False pos. syphilis, fine speck & homogen ANA; IgM; staph/strept infections, colonitis, pancreaitis, gastritis, costochondritis, pericarditis, Hashimoto's, dyspnea, hyper/hypotension, lipedemia, ulcers, pneumonia, anemia, Scleroderma symptoms, vein swelling, etc.  
 
 


kpeachy75
Regular Member


Date Joined Sep 2005
Total Posts : 250
   Posted 8/28/2007 11:35 PM (GMT -7)   
My mom has RA; my dad's aunt has lupus; and my sister, mom, and grandma had breast cancer. My sister's was fatal.
Take care,
peachy
 
Diagnosed with lupus in May 2005
 
Daily Medications:
Prednisone, 5 mg
Imuran, 50mg 2x a day
Warfarin, 5 mg / day
Zoloft, 100 mg / day
Plaquanil, 200 mg 2x a day
Nexium, 20 mg / day
Tramadol, 50 mg 2x a day (as needed) and Tylenol
 
Supplements
1500mg calcium
2000 IU of Vitamin D
400mg magnesium
Centrum Silver (and I am 30!)


Tired Tina
Regular Member


Date Joined Jul 2013
Total Posts : 34
   Posted 7/14/2013 7:10 PM (GMT -7)   
My sister and I both have it, :-(

Barbara Lee
Veteran Member


Date Joined Sep 2003
Total Posts : 2889
   Posted 7/14/2013 8:43 PM (GMT -7)   
Tina:

You've posted on a thread that's really old. I don't believe any of the folks from this thread post anymore. If you would like to know how many of us who currently post have family members with lupus; maybe you could start a new thread asking that.

Otherwise, I wouldn't expect to see many replies here.

Hugs,
Barbara
DX- RA, Lupus, Fibro, LGL Leukemia, Pulmonary Hypertension, Bells Palsy, Gastroparsis, Blood Clots, Cateracts, Glaucoma, Chronic Pericarditis & Pleurisy, Severe Anemia. Way to many medications to list.

Tired Tina
Regular Member


Date Joined Jul 2013
Total Posts : 34
   Posted 8/1/2013 5:28 PM (GMT -7)   
Thanks Barbra;-)
New Topic Post Reply Printable Version
Forum Information
Currently it is Saturday, December 03, 2016 10:52 AM (GMT -7)
There are a total of 2,732,121 posts in 300,996 threads.
View Active Threads


Who's Online
This forum has 151159 registered members. Please welcome our newest member, webers.
268 Guest(s), 7 Registered Member(s) are currently online.  Details
Wdan, sararectenwald1, Jingles1234, Traveler, kcsmith72, luckyman316, iPoop


Follow HealingWell.com on Facebook  Follow HealingWell.com on Twitter  Follow HealingWell.com on Pinterest
Advertisement
Advertisement

©1996-2016 HealingWell.com LLC  All rights reserved.

Advertise | Privacy Policy & Disclaimer