ER, Hives and Plaquenil

New Topic Post Reply Printable Version
[ << Previous Thread | Next Thread >> ]

Gidget^
Regular Member


Date Joined Aug 2007
Total Posts : 171
   Posted 10/19/2007 9:35 PM (GMT -6)   
I spent the evening in the ER with hives. The ER doctor thinks that it is the plaquenil causing the hives. When I got home I googled plaquenil allergy and I found some pics of hives from plaquenil and that's exactly what my hives look like. Has anyone else had a reaction from Plaquenil?

Assuming that it is the Plaquenil causing the hives and I can't take it anymore what's do you think he'll put me on instead? I don't want to go on pred, I already have a weight issue.
Gidget^
 
SLE 9/07, FMS '90's, Spinal Stenosis, Osteoarthritis, Sinus Tach, PVC's, Kidney Stones, RLS, Parotid Neurofibroma 8/04, Cervical Cancer 9/06
Plaquenil, Clinoril, Toprol XL, Prozac, Zyrtec-D, Zocor, Vitamins B6 & B12, Folic Acid, Toradol, Percoset, Loratab
 
There is no psychiatrist in the world like a puppy licking your face.
 
 


AlwaysRosie
Veteran Member


Date Joined Jan 2005
Total Posts : 8616
   Posted 10/19/2007 10:51 PM (GMT -6)   
Hi Gidget . . . there are some who can't tolerate the fillers in the generic version of plaquenil and they do fine on the name brand drug. But your allergy sounds like it could actually be an allergy to the active ingredient. I'm hoping some of the others who had to switch will post and let you know what their issue with the generic was.

Glad you are back home and safe. Doc will decide what to try next depending on your symptoms. . . their is another anti-milarial, but I don't recall the name of it.

Blessings!

In His Grip

AlwaysRosie           "We can't control the waves, but we can learn how to surf!!"

Psalms 139

Co-Moderator - Lupus Forum

UCTD, Hashimotos, Inflammatory Bowel, Inflammatory Arthritis

Clickable Links:  Lupus Resources    Lupous.Org   Lupus Criteria (4 of 11)   Lupus Chapter Locator


Gidget^
Regular Member


Date Joined Aug 2007
Total Posts : 171
   Posted 10/19/2007 11:19 PM (GMT -6)   
Thanks Rosie tongue ... it always seems like if it isn't one thing, it's another! Good thing this didn't happen last weekend when I was in San Antonio.

After the "mixed" cocktail shot they gave me in my bum I was getting tired so I went to go lay down and all I did was toss and turn. RLS tonight isn't helping matters any! I ended up getting back up and sitting down with the notebook to keep myself busy for awhile. I've got two little Yorkies who'd rather me play with them than use the computer though, so I might end up being talked into a good game of tug or ball for awhile.

Hope you're doing good. How's the puppies btw?
Gidget^
 
SLE 9/07, FMS '90's, Spinal Stenosis, Osteoarthritis, Sinus Tach, PVC's, Kidney Stones, RLS, Parotid Neurofibroma 8/04, Cervical Cancer 9/06
Plaquenil, Clinoril, Toprol XL, Prozac, Zyrtec-D, Zocor, Vitamins B6 & B12, Folic Acid, Toradol, Percoset, Loratab
 
There is no psychiatrist in the world like a puppy licking your face.
 
 


cured4real?
Veteran Member


Date Joined Dec 2005
Total Posts : 1942
   Posted 10/19/2007 11:44 PM (GMT -6)   
Hi Gidget,
You mentioned you have a weight issue, as do I, have they checked you for diabetes, hyperinsulinemia (high insulin), or fatty liver? I ask you this because your ability to tolerate medication is directly related to how well your liver function and almost everyone overweight has problems with insulin, prediabetes, metabolic syndrome, fatty liver disease as these problems are both caused by and cause weight gain and it is impossible to lose weight with these problems, but there is treatment also. As many as one in four people are ending up getting liver transplants who have complications from fatty liver disease. I am frequently troubled with medication allergies because my liver doesn't tolerate medicine. Unlike my son, who is allergic to a medicine on the first dose, it takes a month or two or even more for the medicine to back up in my system due to my bad liver to then trigger an allergy. Toradol is extremely hard on the liver, it nearly killed me. Prozac is another. Plaquenil is usually processed more by the kidneys, but if you have UT problems then that makes sense. I hope you feel better and they can get you on another medicine or a different version that works for you. I'm sorry to be on my soapbox about the hyperinsulinemia, prediabetes, fatty liver stuff, but it can cause a number of very serious problems, including autoimmune disease, endocrine problems, and more and there is treatment for the condition. Treatment and special dietary changes for fatty liver has allowed me to eat much more plentifully and to lose weight and keep it off, while lowering my cholesterol. My liver just doesn't like to burn fat. Well, I hope you are diong better and sorry to butt in with this, but just wanted to let you know. If your liver enzymes are high, it would really be worth it to talk to your gi or better a knowledgeable hepatologist about this or at least to get your docs to rule it out if you think it might be a problem.
Love, Marji
--Doctors are men who prescribe medicines of which they know little, to cure diseases of which they know less in human beings of whom they know nothing.--Voltaire (1694-1778)
Ills--Sjogrens-Lupus-like AI Disease, Hashis, Vitiligo, spinal stenosis/fusion with plate, salivary/lymphectomies, Diabetes, NAFLD, COPD, RLS, neuropathy, trigonitis, hystero, diffuse brain atrophy
Meds--Plaquenil, Evoxac, Metformin, Synthroid, HCTZ, Estradiol patch, Prosed, Klonopin, Soma, Ultram, Vicodin, Restasis, Albuterol,steroid injections, Protopic & Triamcinolone Acetonide ointments


Gidget^
Regular Member


Date Joined Aug 2007
Total Posts : 171
   Posted 10/20/2007 8:56 AM (GMT -6)   
Marji,
Thank you for your imput. I do have a fatty liver and mildly elevated liver enzymes. One time I tested postive for Anti Smooth Muscle Antibody. My old liver doctor felt that if I lost some weight I would be able to get rid of the fatty liver. Easier said than done lol I'm not grossly overweight but I could lose 40 pounds and look a heck of a lot better than I do right now.

I guess it's time to go to my PCP and sit down and review all my meds to see if there is anything that can be done. I'll also speak to both doctors about seeing a liver specialist. I believe that a lot of people with fatty liver disease end up being diagnosed with NASH. It was very hard convincing the liver doctor that I didn't have a problem with alcohol. Quite annoying actually because he said that he would interview my relatives to see if I was lying. I wasn't a happy camper with this doctor.

One of my very best friends that I've had since 3rd grade contracted Hep C from a blood transfusion after she had her second baby. 20 years later she's scheduled for a hysterectomy when the doctor calls and tells her that something is seriously wrong and he can't operate on her. Tests were run and it turned out from unknowingly having Hep C for 20 years she was in liver failure. She was immediately put on the transplant list while they tested her sons. It turned out her youngest son was a match and surgery was done. Three days after surgery she started to go into liver failure again because the blood vessels from her son's liver was collapsing and causing blood clots. It was at that point a life or death situation and they gave her 24 hours to live unless she had another liver transplant. There was a young man's family in Dallas that donated their son's liver when he died and she was transplanted with it. It's been 6 years now and she still has the Hep C and has to take Cellcept and Interferon. It makes her so sick and she always ends up in the hospital from the medicine just beating her body down but it keeps her alive. She's found a new liver doctor that wants to change her treatment to maintenance doses to see if they can keep the liver damage at bay and let her lead a better life than 5 days in bed, 1 day feeling so-so and one day feeling good.

I only use Toradol when I am passing a kidney stone and never for more than a couple days, which is basically long enough to get in for medical care. I know it can be a nasty drug if you use it more than a few days at a time. I'm not a huge fan of pain meds. I'll use them when I absolutely have to, to get something done, but if I can deal with it without the pain pills I do. Usually tooth aches and kidney stones are the two I can't go without pain meds!

Marji, I noticed in your sig that you have had salivary/lymphectomies. I have also had one salivary lymphectomy and also total removal of one parotid gland with a neurofibroma branching off the parotid gland. The neurofibroma was a cyst with a tumor inside the cyst. The cyst was on one of the two main nerves in my cheek. All tests indicated it was cancer but when I had the delicate surgery the path tests came back benign. After sending it to three different pathologists my doctor felt comfortable in giving me a benign diagnosis. The rheumatologist I'm seeing now gave me the impression that this was a Lupus. Did your doctor say that it was possibly lupus related?

In closing this long (and probably not making much sense LOL) post I was wondering how they are treating your fatty liver and what dietary changes you made. Thanks again Marji for your imput!
Gidget^
 
SLE 9/07, FMS '90's, Spinal Stenosis, Osteoarthritis, Sinus Tach, PVC's, Kidney Stones, RLS, Parotid Neurofibroma 8/04, Cervical Cancer 9/06
Plaquenil, Clinoril, Toprol XL, Prozac, Zyrtec-D, Zocor, Vitamins B6 & B12, Folic Acid, Toradol, Percoset, Loratab
 
There is no psychiatrist in the world like a puppy licking your face.
 
 


Audrey Ann
Veteran Member


Date Joined Jul 2005
Total Posts : 815
   Posted 10/20/2007 9:46 AM (GMT -6)   
Greetings Gidget!

In reading your posts I noticed you have trouble with kidney stones. I have terrible trouble with kidney stones, too. I used to take toradol for my pain (it was VERY effective) but when I started having stones regularly, my doc put me on methadone. The methadone helps with the stone pain and the RA pain I deal with. Also, it does not make me sleepy or feeling like I am tipsy. It just addresses the pain and I can pretty much function. I do have regular blood work to test my liver function but that is mostly related to the methotrexate shots I take. My family doc says methadone is pretty safe and often over-looked as a solution for pain because it is an older drug and usually used for heroin addicts (or something like that...).

Please let me know about your kidney stones and treatment. Did you have hyper-parathyroid? I have been to Mayo, to Univ. of Michigan, to Cleveland Clinic, and to many specialists and no one can explain why I have hundreds of kidney stones. Basically they think my body just dumps out all my calcium through my kidneys. My kidney specialist has me on high blood pressure meds that are calcium channel blockers. I also take actonel because I have osteopenia (the start of osteoporosis).

With that all said, I hope you get answers soon to your allergic reaction to the plaquenil. There are many drugs available to help us with lupus so I would think there are still a few options for you.

Good luck!
Prayers,
Audrey Ann
 
Lupus and RA and LOTS of Medications!
 


 


Weleetka
Regular Member


Date Joined Oct 2007
Total Posts : 182
   Posted 10/20/2007 1:30 PM (GMT -6)   
I had a reaction.. My tongue swelled up and I wanted to claw my face.... I took 4 pills and Dr. told me to stop when I called and told him what was happening...

Gidget^
Regular Member


Date Joined Aug 2007
Total Posts : 171
   Posted 10/20/2007 2:49 PM (GMT -6)   
Hi Audrey,
Wow the Toradol doesn't do anything to me besides take away the pain. I can function normal on it when I take it. My dosage is 10-20 mg, maybe yours is more and that's why you have a harder time functioning while taking it. The only thyroid issue I have is that the left side of my thyroid gland is enlarged and my numbers tend to run on the low side but I guess never low enough to treat. It seems that thyroid problems run on my mom's side of the family. I can count of more people alive on my mom's side that have thyroid issues compared to who doesn't. Strange isn't it?

Normal treatment for my stones is I try to pass it on my own. If I get too much blood in my urine or the stones get too large then I go ahead and have lithotripsy. My last two stones I had the treatment for were 4mm and 5mm which are almost impossible to pass on your own. The last litho took 1,500 hits which is about 750 hits more than normal. That stone was extremely hard. I got home from the procedure turned around and went back to the hospital where they admitted me and managed my pain meds. Unfortunately that whole experience went on my deductible and the insurance company didn't cover it.

I only took my Toprol, Zyrtec-D, and Prozac this morning. I am starting to get the hives back in my feet but that's not unusual. Tomorrow I'll only take the Toprol and Zyrtec and hold off on everything else including the Prozac until I can talk to my PCP. I know that you can have hives off and on for a few weeks after an allergic reaction so it probably isn't the Prozac but I'll stop it just in case. I hate when I get the hives on my feet, it's almost impossible to get the itching to stop!


..... Weleeka, You had a quick reaction to the Plaquenil. I've never had my tongue swell from an allergic reaction and it's not something I care to ever experience. I hope you are doing better now, and the dr has found an alternative treatment for you.
Gidget^
 
SLE 9/07, FMS '90's, Spinal Stenosis, Osteoarthritis, Sinus Tach, PVC's, Kidney Stones, RLS, Parotid Neurofibroma 8/04, Cervical Cancer 9/06
Plaquenil, Clinoril, Toprol XL, Prozac, Zyrtec-D, Zocor, Vitamins B6 & B12, Folic Acid, Toradol, Percoset, Loratab
 
There is no psychiatrist in the world like a puppy licking your face.
 
 


cured4real?
Veteran Member


Date Joined Dec 2005
Total Posts : 1942
   Posted 10/21/2007 1:26 PM (GMT -6)   
Hi gidget--
So glad you got the liver checked out and know you have fatty liver. So many people with stubborn weight gain don't bother and get so sick eventually. Fatty liver is always NAFLD (non-alcoholic fatty liver disease) and if your enzymes are elevated and/or bx show inflammation it is then upgraded to non-alcoholic steato hepatitis-- fatty liver hepatitis. Of course, they don't know what causes it, mostly they blame the patient. Everyone on one side of my family has it, so it seems genetic, also it causes increased ANA and other autoimmune disease, so I think eventually it will be classified as an autoimmune disease.

I take glucophage, which has prolonged my fathers life and is helping me. I am on a low carb diet with moderate to more than moderate amount of fat. My doctor told me that by restricting my fats, the liver thinks you are fat starved and stores more carbs as fat in the liver, so that low fat diets make it worse. My cholesterol was high, but came down by following this diet, though it went up first, then down. Essential fatty acids and vitamin E are supposed to be good for you. I eat meat and mostly green antioxident rich vegetables, since oxidative stress (lack of antioxidents) has been suggested to cause the disease to progress to cirrhosis. My father has cirrhosis but is very healthy, I don't know how bad my liver is now. My last bx showed that every cell was as full as it could be with fat and I am told I have NASH.

I really question you taking toradol for pain. Methadone is very bad for you, causes bad osteoporosis, is more addicting and dangerous than heroin and there is plenty of documentation for that. I'm allergic to it and to toradol. I take hydrocodone or opiates for breakthrough and Ultram (tramadol) for chronic pain which works well for me, and my liver seems fine with it. I really think that you need to find a doctor who is not prejudiced, who believes in you and supports you in saving your liver by getting you off NSAIDs and on liver friendly pain medicine. Almost anything non-narcotic besides Ultram is very hard on the liver.

Your doctor sounds completely uneducated about fatty liver since he is not treating you. You need to get your blood insulin tested, this is critical in determining whether you are a skid row drunk vs. someone with a pre-diabetic metabolic disorder. Instead of insulting you, he should be running bloodwork. then you need a glucose tolerance test to make sure that you do not have diabetes or mild diabetes and how well you process carbs/sugars. Also, go to a hepatologist, not just a gi guy, and go somewhere good. Glucophage is the front line treatment for hyperinsulinemia (high blood insulin) also called "metabolic syndrome x" also called "pre-diabetes" and diabetic fatty liver or just fatty liver. There are several good articles out about this condition and several clinical trials, maybe you can take part if they are in your area?

The normal blood test every doctor swears by will not show prediabetes or even diabetes, though all docs swear its the best test, really the insurance companies are the ones who like it because they can treat fewer people. You need to have your blood insulin level tested--a good hepatologist will do this for you if you ask. My insulin was extremely high, a sign of NAFLD and pre-diabetes. Eventually, if I keep up with high insulin, my pancreas will not be able to produce anymore and I will end up with diabetes and have to take insulin. I will always have to take the glucophage, because it is for the liver, it gets the fat out of the liver.

I do not take milk thistle and got sick from it.

My neck is a mess, I have a plate and four screws in it and bad arthritis. I also had all those lymph nodes and salivary glands out and they were all benign but would have turned into cancer eventually because they were bad. They are probably burnt out from autoimmune disease, since they produce the antibodies that make us sick and I had a lot of throat infections as a child. My doc says its from sjogren's syndrome. I also was stabbed in the temple during a home invasion and got blood poisoining in it. I have been told that stabs into the empty space in your head (which is most of mine LOL) can cause infections lower in your neck and jaws years and years later. I read an account of a man who got shot in the temple with a framing nail gun and he had to have all his lymph nodes and salivary glands removed and they thought it was cancer but it was benign and due to infection there in the empty cavities in and around the neck. Leaking fillings, mouth infections can cause the same problem, as can sjogrens and I imagine lupus. I hope you don't have to have more our. I have four nice big scars on my neck and it looks like someone tried to cut my head off! Anyway, I'm glad you know about the liver and hope you get to a really good and non-judgemental and non-accusatory hepatologist so you can get treatment instead of insults. And if a doc gives you that alcoholic crap, tell him that people generally accuse others of what is true for themselves, or just that "he's wrong" and you want to be tested and treated as is proper in your case. Personally with the liver destructive meds you are on, it would be hard to tell what was going on. It may be that they change you to kinder meds, your liver may heal and your fatty liver may go away, it can be caused from drugs as well as alcohol. You have a right to put your liver first and get good safe pain meds and if your docs don't believe you, then you need to get another opinion and find someone who cares. Sorry so long. I'm glad you posted back.
Love, Marji
--Doctors are men who prescribe medicines of which they know little, to cure diseases of which they know less in human beings of whom they know nothing.--Voltaire (1694-1778)
Ills--Sjogrens-Lupus-like AI Disease, Hashis, Vitiligo, spinal stenosis/fusion with plate, salivary/lymphectomies, Diabetes, NAFLD, COPD, RLS, neuropathy, trigonitis, hystero, diffuse brain atrophy
Meds--Plaquenil, Evoxac, Metformin, Synthroid, HCTZ, Estradiol patch, Prosed, Klonopin, Soma, Ultram, Vicodin, Restasis, Albuterol,steroid injections, Protopic & Triamcinolone Acetonide ointments


Gidget^
Regular Member


Date Joined Aug 2007
Total Posts : 171
   Posted 10/21/2007 4:52 PM (GMT -6)   
Marji,
I guess I should clarify about the Toradol. I usually only take it if I am passing a kidney stone or it's pinging around my kidney, which hopefully is no more than once every year or two. If the Toradol doesn't help then I will take Percoset to keep me out of the hospital. If it gets that bad I know I'm either headed towards the doctor or hospital because something is going on. My PCP did give me a script of 30 Toradol to keep on hand when my shoulder gets real bad. We have a mutual understanding that I will only take one or two once a week if I need it. So far I've had the script filled for three months and I've only taken one. I had to do that one night because I was in tears and couldn't stand the pain any longer. My usual course for pain meds with the lupus, fibromyalgia and my back is Hydrocodone. I'm very careful about any of the drugs I take, especially the ones that come with the warnings like Toradol does. One of the reasons I never experimented with drugs in school was because I was afraid I'd do something to myself. I've developed a very good relationship with my doctors and they trust me because they know I will not abuse the pain or anxiety meds they give me.

The liver doctor in question was where I use to live so I don't have to deal with him anymore. More than likely what messed up my liver to begin with was when I was on Tamoxifen for breast cancer prevention. I was into my third year of five when the liver enzymes started going up. They took me off the Tamoxifen and any other drug that they thought could possibly be causing it and slowly put me back on what drugs I needed. Their thought was that it caused a little liver damage. Who knows what is really the problem. I could drive myself crazy wondering and worrying!

When I had the parotid gland and neurofibroma removed they cut my face like I was having a face lift (at the hairline by my ear, around my ear and then down my neck). Too bad they didn't do a face lift when they did that because they had to peel my face away from my head to get at everything. Then again I would have had a wrinkly side and a smooth side so it's probably a good thing they didn't do half a face lift LOL

Thank you for being so concerned, everyone here is so great, I'm so glad I found this forum!
Gidget^
 
SLE 9/07, FMS '90's, Spinal Stenosis, Osteoarthritis, Sinus Tach, PVC's, Kidney Stones, RLS, Parotid Neurofibroma 8/04, Cervical Cancer 9/06
Plaquenil, Clinoril, Toprol XL, Prozac, Zyrtec-D, Zocor, Vitamins B6 & B12, Folic Acid, Toradol, Percoset, Loratab
 
There is no psychiatrist in the world like a puppy licking your face.
 
 


cured4real?
Veteran Member


Date Joined Dec 2005
Total Posts : 1942
   Posted 10/21/2007 9:52 PM (GMT -6)   
Hi gidget, you are probably right. They say that fatty liver may be genetic and some people have a predisposition, but something has to occur (oxidative stress) to cause the disease to start and a second hit to progress. Likely the medicine you took kicked it off, like you said. When I realized how genetically prevalent fatty liver seems to be, I warned my sons of potential problems and to take care of themselves, especially by taking anti-oxidants, well eating them in food. Anyway, I begged for lipo and got some when I got my submandibulars done on each side. I have a big scar like you describe coming down past my parotid and then another short one on the other side, then another incision across the front more by my collarbone and then a big huge zipper scar up from between my shoulder up to the base of my skull. I will always have long hair as a result. I look like a turkey neck since they left the parotid and between that and my thyroiid swelling I get goofy looking and I know I will probably end up with the parotid out because it hurts alot and is going bad like the rest. I wish they just cut me all across and took them all out, personally, at least itd just be one big scar and all done at once. I know what you mean by half a face lift. They did a little more nip and tuck and lipo on my last excision than they did on the first (I had a cooler better doc that was a real sweety and did a great great job and used to be a very popular plastic surgeon) and so I'm uneven, especially when things swell. I also have really swollen ones that are back by your ears, what ever ones they are, my rheumie always feels them and they make me look like a chipmunk or something and as far as I'm concerned they can take them as well. As you can tell, I'm over it with scars, they hide them pretty well, I'm just sick of the pain and problems.
On the liver, if your enzymes keep being elevated, they can do an abdominal ultrasound with the baby ultrasound thingie and it's really worth having done every few years to make sure that its not spreading. They can tell fatty liver really well from ultrasound becuause liver blubber vibrates differently from any other type of liver tissue. Then maybe you can think about the tests. I'm on a soapbox about prediabetes because I know for a fact that you can lose weight, feel better, and be healthier and prevent bad problems just by modifying diet and perhaps addition of glucophage or other meds. I was the sad hopeless really fat girl that never thought she could lose weight, I was told I was decompensating from liver disease and dying slowly, and it was all hopeless. Then I went to Borland Groover and they changed everything. I've lost over sixty pounds and kept them off for over five years. I eat very well when my gi tract isn't a mess, and never need to be hungry. My liver enzymes have been normal for the first time in over thirteen years and have stayed normal. Glucophage and weight loss brought them down, and even my cholesterol has gotton down close to normal and even been normal on some tests. There is hope, and obese people can lose weight if the docs simply figure out what is wrong. Well take care and nice chatting.
Love, Marji
--Doctors are men who prescribe medicines of which they know little, to cure diseases of which they know less in human beings of whom they know nothing.--Voltaire (1694-1778)
Ills--Sjogrens-Lupus-like AI Disease, Hashis, Vitiligo, spinal stenosis/fusion with plate, salivary/lymphectomies, Diabetes, NAFLD, COPD, RLS, neuropathy, trigonitis, hystero, diffuse brain atrophy
Meds--Plaquenil, Evoxac, Metformin, Synthroid, HCTZ, Estradiol patch, Prosed, Klonopin, Soma, Ultram, Vicodin, Restasis, Albuterol,steroid injections, Protopic & Triamcinolone Acetonide ointments

New Topic Post Reply Printable Version
Forum Information
Currently it is Friday, October 31, 2014 1:34 PM (GMT -6)
There are a total of 2,256,187 posts in 250,960 threads.
View Active Threads


Who's Online
This forum has 157717 registered members. Please welcome our newest member, Alzheimer's daughter.
120 Guest(s), 12 Registered Member(s) are currently online.  Details
tdnjam, Scaredy Cat, Girlie, Dolph ziggler fan, NiceCupOfTea, Alzheimer's daughter, Carole_D, Poppie, Binduspire, Cornell, super max, minnietoty


Follow HealingWell.com on Facebook  Follow HealingWell.com on Twitter  Follow HealingWell.com on Pinterest  Follow HealingWell.com on YouTube
Advertisement
Advertisement

©1996-2014 HealingWell.com LLC  All rights reserved.

Advertise | Privacy Policy & Disclaimer