I've been doing a lot of reading on the Anti dsDNA because mine are so high. I'd be glad to share with you the information I've come up with.
I bet your lab tests are being done at either Quest Diagnostics or LabOne. LabOne a few years ago came up with a new way to measure the antibodies. Instead of the old method of diluting the blood till no antibodies could be found they've found a way to count each cell in a certain amount of blood if they had antibodies in them. A lot of labs are still reporting in the old method of titers. The original ANA is now ANA-D or ANA-Direct. It's a much more precise way of reporting how high the antibody levels are than in titers (i.e. (1:160, 1:320).
At Quest Diagnostics or LabOne both the dsDNA and the ANA-D normal is 0-99, borderline is 100-120. Anything above 120 is positive.
According to the Lupus Foundation antibodies to DNA (ssDNA, dsDNA)(the protein that makes up the body's genetic code) are found primarily in SLE. Disease activity correlates with a rise in Anti-DNA as well as other specific blood tests.
From Hycor Biomedical the Anti-dsDNA antibodies have been suggested to be directly involved in the disease process, being included in the ARA criteria for the diagnosis of the disease. In SLE patients, levels of anti-dsDNA antibodies can be used in the monitoring of disease activity, since rapid increases have been reported to precede exacerbation of the disease and falls in antibody levels often accompany drug therapy. Anti-dsDNA antibodies are not detected in the sera of patients with drug induced lupus.
I could keep pasting information I've gathered but it basically says the same thing, just different wording. When dsDNA is positive, it indicates how active the lupus is right now in your body and a greater chance of kidney involvement. The higher the number the worse it is.
Hope this helps.
SLE 9/07, FMS '90's, Spinal Stenosis, Osteoarthritis, Sinus Tach, PVC's, Kidney Stones, RLS, Parotid Neurofibroma 8/04, Cervical Cancer 9/06
Clinoril, Toprol XL, Prozac, Zyrtec-D, Zocor, Vitamins B6 & B12, Folic Acid, Loratab ,Percoset, Toradol
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