Methotrexate and stomach issues

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ericsmom
Veteran Member


Date Joined Jan 2007
Total Posts : 1042
   Posted 11/26/2007 9:23 PM (GMT -6)   
Hello everyone,

I am not new, just havent been around much due to the fact that in Sept this year they changed my lupus dx to fibromyalgia
My rhuemy started me on methotrexate 4 weeks ago, and I am still having major stomache probs. Have any of you had any probs with mtx, and if so, did the adverse side effects subside eventually?

Thank you in advance
Diane
Fibromyagia, R/A, Diabetes, Atrial Fib, depression

Prednisone(not for much longer I hope), methotrexate, folic acid, metformin, diamicron, bisoprolol, plaquinal, fenofibrate, pantoloc, wellbutrin, propafenone, ibprofen, warfarin


What doesn't kill us, makes us stronger


elcamino
Veteran Member


Date Joined Sep 2005
Total Posts : 1740
   Posted 11/27/2007 7:25 AM (GMT -6)   

Hi.  I wasn't aware that they treated fibromyalgia with methotrexate?  I always assumed that if you respond to mtx, you DON'T have fibromyalgia and have an inflammatory arthritis instead.  Maybe that's why your doctor put you on mtx?  In any case, when I first started taking mtx, I also had some stomach issues.  I had a lot of nausea and some lower GI cramping that occurred for just a few days after taking the weekly mtx.  Gradually, it resolved completely and I have no issues with mtx at all.  Are you sure your stomach problems are related to the mtx?  I know that if they continue or are bothersome, you can be prescripted mtx in injectable form so it bypasses your stomach.  Mtx has been a great drug for me so far.

 

El


Current dx: Rheumatoid Arthritis
Suspected dx: UCTD/Early Lupus
Current Meds: Enbrel, Plaquenil, Aciphex, Ultracet, Zyrtec, Allavert-D, Zantac, Tylenol PM
Past Meds: Relafen, Vioxx, Mobic, Voltaren, Sulfasalazine, Entocort, Prednisone, Humira, Reglan


ericsmom
Veteran Member


Date Joined Jan 2007
Total Posts : 1042
   Posted 11/27/2007 9:08 AM (GMT -6)   
Morning El,

Thank you so much for you reply. The mtx is for my R/A and pericarditis issues, and also to get me off off the prednisone. I am going to try to talk with that doc later in the week and see if he will consider the injections.

Hope you are having a pain free morning El

Hugs,
Diane
Fibromyagia, R/A, Diabetes, Atrial Fib, depression

Prednisone(not for much longer I hope), methotrexate, folic acid, metformin, diamicron, bisoprolol, plaquinal, fenofibrate, pantoloc, wellbutrin, propafenone, ibprofen, warfarin


What doesn't kill us, makes us stronger


Trying2BFree
Regular Member


Date Joined Oct 2005
Total Posts : 251
   Posted 11/27/2007 9:37 AM (GMT -6)   
Good to see you back Diane!  I always see people saying to take MTX with a high carb meal like pasta or rice.  It seems to work for me.  Another thing is to drink a lot of water around your MTX day.  And probably the biggest thing is the folic acid.  I was taking 1mg (prescription) of it in the beginning but was having mouth sores and nauseua.  My rhreumy switched me to Metanx.  It's a prescription too but is a higher dosage with some B6-12 in it.  That made a big difference for me.  I don't have any side effects now.

Jeannie 
SLE diagnosis 10/05 now changed to RA 3/06, Endometriosis 5/05, PCOS 1990
Meds: Metformin ER 1500mg (PCOS); Loestrin BCPs (Endo); Methotrexate 15mg (RA); Metanx 5mg (RA); Orencia 750mgs (RA); Lunesta 2mg (as needed); Prevacid


ericsmom
Veteran Member


Date Joined Jan 2007
Total Posts : 1042
   Posted 11/27/2007 12:56 PM (GMT -6)   
Thank you Jeannie, it's really good to see you too :-) I hope you have been keeping well.
Maybe my problem is the folic acid, he has me take 2.5 mg 2 days after my mtx dose. So far, I dont have any mouth sores, just the nausea.
I am taking the same mtx dosage as you 15 mg.

You girls are really helping me...thanks sooooooooo much

Love and hugs
Diane
Fibromyagia, R/A, Diabetes, Atrial Fib, depression

Prednisone(not for much longer I hope), methotrexate, folic acid, metformin, diamicron, bisoprolol, plaquinal, fenofibrate, pantoloc, wellbutrin, propafenone, ibprofen, warfarin


What doesn't kill us, makes us stronger


Trying2BFree
Regular Member


Date Joined Oct 2005
Total Posts : 251
   Posted 11/27/2007 2:41 PM (GMT -6)   
I take the Metanx every day except for MTX day. Maybe try doing that.
Jeannie 
SLE diagnosis 10/05 now changed to RA 3/06, Endometriosis 5/05, PCOS 1990
Meds: Metformin ER 1500mg (PCOS); Loestrin BCPs (Endo); Methotrexate 15mg (RA); Metanx 5mg (RA); Orencia 750mgs (RA); Lunesta 2mg (as needed); Prevacid

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