1. More Evidence Showing that Lyme Spirochetes May Persist Even After Antibiotic Treatment
Abstract: The effectiveness of antibiotic treatment was examined in a mouse model of Lyme borreliosis. Mice were treated with ceftriaxone or saline solution for one month, commencing during the early (three weeks) or chronic (four months) stages of infection with Borrelia burgdorferi. Tissues from mice were tested for infection by culture, PCR, xenodiagnosis, and transplantation of allografts at one and three months after completion of treatment.In addition, tissues were examined for the presence of spirochetes by immunohistochemistry. In contrast to saline solution-treated mice, mice treated with antibiotic were consistently culture negative, but tissues from some of the mice remained PCR positive, and spirochetes could be visualized in collagen-rich tissues.
Furthermore, when some of the antibiotic-treated mice were fed on by Ixodes scapularis ticks (xenodiagnosis), spirochetes were acquired by the ticks, as determined based upon PCR results, and ticks from those cohorts transmitted spirochetes to naïve SCID mice, which became PCR positive but culture negative.
Results indicated that following antibiotic treatment, mice remained infected with non-dividing but infectious spirochetes, particularly when antibiotic treatment was commenced during the chronic stage of infection.
Hodzic E, et al. Persistence of Borrelia burgdorferi following Antibiotic Treatment in Mice. Antimicrob Agents Chemother. 2008;52(5):1728-36.
Thanks for sharing this. I had read it previously and agree w/you. Its always good to hear from you.
And Peter - exactly!
All the more reason for HR741 to be passed for imperative R&D and the develpment of an early diagnostic and "no matter what stage" treatment tool that is targeted specifically to the elusive nature of this drill species.
If we can see the common sense, it never ceases to amaze me that certain academics cannot; and then I re-center and know the answer to my own frustration - human nature at its best.......and worst.
I appreciate these threads.
"God loves with a great love the man whose heart is bursting with a passion for the impossible." ~booth
www.stylebyheatherrose.com -click "Lyme testimony" and "Lyme Disease" for a panoramic view of the truth. Lyme disease - coming to a tick near you!