My daughter is taking Plaquenil and has been on it for six weeks. I was told by another lyme sufferer that it takes about 12 to 16 weeks to actually start seeing the signs of improvement from it. The bad thing is that my daughter cannot stand the taste of it because we have to cut the pill in half. Well, yesterday I had an idea to use the capsule that her probiotic comes in (we have to empty the probiotic capsule anyway) and put the pill inside it. Now it is not a problem at all taking the medicine. The capsule just dissolves anyway, so I don't see any harm done, and she is taking it without a problem. What have you heard about the time before it starts taking effect? I'm so happy to hear that you are feeling better. We're still waiting to see improvement -- six weeks may be too soon (Plaquenil and Zithromax) and four weeks (Mepron and Artemisinin for Babesia).