I wouldn't take it in one dose. It will probably get your stomach upset. You can space it out 8 hours apart. Who told you 12 hours? Only Mepron is to be spaced out 12 hours.
Also, you should take you acidophilus 2 hours after or 2 hours before your meds. 2 hours after is usually best so the bacteria can build up and not be killed off again by the antibiotics. It is also good to take a night dose too.
I hope this helps.
2003 symptoms started;panic attacks,anxiety,heightened senses.
2007 Diagnosed with Lyme. Didn't start treatment.
2008 symptoms came back with a vengence.
2009 Diagnosed with Lyme plus co-infections....Babesia and Bartonella.
Illnesses:-Chronic Lyme Disease,Hashimotos Thyroiditis, Ulcers, Hypoglycemia
Medications:-Biaxin 250mg to start,Mepron,Ultram,Thyro Complex 60mg,Probiotics and supplements