Methotrexate suppresses the immune system, so be careful with this medication. I was on it for 6 months and I felt horrible the entire time from the side-effects, and it did nothing to help the underlying cause of my condition (misdiagnosed at that time as Crohn's Disease; now I know it was not Crohn's, it was and still is Lyme).
If methotrexate (MTX) is still the medication of choice, make sure folic acid supplements are also taken - the drug doesn't work without folic acid, and also the folic acid helps cut down on the intensity of the side-effects. I think my problem at the time I was on the MTX is that I wasn't taking enough folic acid. I've seen recommendations as high as 2mg/day - I was only taking 800mcg/day.
Chronic Lyme Disease, Gluten & Sulfite Sensitivity, Many Food/Inhalant/Medication/Chemical Allergies & Intolerances, Asthma, Gut issues (dysmotility, non-specific inflammation), UCTD ("Secondary Lupus-Like Syndrome"), Osteoporosis, Pancytopenia, chronic malabsorption/malnutrition, etc.; G-Tube; Currently TPN-dependent.
Meds: Zofran, Pulmicort, IV Ceftazidime, Heparin (to flush PICC line), Claritin, Colloidal Silver (used topically), probiotics, homeopathy.