Need Help w/ Labcorp CD57 please

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+Lyme
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Date Joined Apr 2009
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   Posted 7/30/2009 6:37 PM (GMT -6)   
 I apologize cause I'm not asking anyone to do my research for me.... And I have just started out searching, but need to email my parents about my LLMD appt today. So I'd like to get at least a couple opinions, or point me somewhere.  Hopefully others will be helped, also.  I could have sworn there were some posts about this in the past but I can't find the posts that had information on this.
 
All I can find in Dr. Burr's piece is that he likes to see his lyme patients in the 60's.
 
Labcorp did my CD57.
 
My Abs CD8-CD57 + Lymphs is 60.   Range is 60-360.  The Dr did not make much remark on it and said it was within normal range, tho low.  My concerns:  my labs show 'high, out of range' results on mono, HHV6, parvovirus B19 and Babesia, which shows possibly 'acute'.
 
Even tho my adrenals and testosterone were within range, he said they were low enough to make me feel bad (I'm a lady, OK?)
 
So, I had hoped that the CD57 would be a very definitive result for Lyme, or else I was in trouble somewhere else.  When LLMD ordered the test, he said it was more reliable than the WB, but here I am w/ not much comment on it.
 
I seem to recall some here discussing the 2 different numbers.  My number on top is:
%CD8-/CD57+ Lymphs and it is 3.
 
Then there's a whole list of 'immunophenotyping markers for investigational use only' and I suppose it will take me another weekend to research these!
 
Since I have all these viruses, etc, I was hoping my CD57 would be indicative of lyme.  Is 60 too high for this? Also, so far in searches, I do see CD57 associated w/ other illnesses, so again -- that's probably another weekend of research!
 
Some of my hormones are too low, also -- you know, I'm wanting to say that all this stuff is attributed to Lyme and the Dr HAD given me a clinical diagnosis, added to 'well, the labs seem to indicate also.'
 
Anyone, what is your best opinion of the CD57 if my numbers are this good. (tho I know not high) The tick bite that I attribute my lyme to occurred a little over 2 yrs ago, not as old as many of yours.


 

Post Edited (+Lyme) : 7/30/2009 7:27:55 PM (GMT-6)


1bitten2xshy
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   Posted 7/30/2009 7:27 PM (GMT -6)   
At my very sickest, my CD57 was 360!

Many LLMD do not hold alot of stock in the CD57 test, and then others want to treat you until it is at least over 200.

It can be very confusing!
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+Lyme
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Date Joined Apr 2009
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   Posted 7/30/2009 7:30 PM (GMT -6)   
Bitten, well, yeah, it is confusing, beause at my first visit, he immediately prescribed it, saying 'It's a lot more reliable than the WB.' And so now, it's not definitive enough? Doesn't really matter, he gave me lyme diagnosis based on everything altogether.

Well, shoot! If yours was 360 (I think the highest range there is!), how could you be so sick?
 


1bitten2xshy
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Date Joined Jun 2007
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   Posted 7/30/2009 7:33 PM (GMT -6)   
Exactly...that is when I was CERTAIN I was going to die. It was right before I started treatment.

Now, 2+ years of treatment and my CD57 in April was 205.

There is no rhyme or reason to this stinky disease.

That is why Lyme really is a clinical diagnosis. Tough when you are trying to prove it to someone I know.
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Life is not about waiting for the storms to pass...it's about learning how to dance in the rain


+Lyme
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Date Joined Apr 2009
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   Posted 7/30/2009 8:50 PM (GMT -6)   

Well, sure it's hard to prove you have Lyme.  It's hard to prove other illnesses as well.  I won't say all LLMDs are infallible, but if one has given you a clinical diagnosis, that is really 'proof'.

I am pasting below a bit of a piece on CD57 from Health Centers of America. Altho this does not help me w/ the other numbers given on the test.

Test interpretation: Low CD57 occurs in chronic Lyme or when the disease has been active for over 1 year. The count reflects the degree of infection. It is not a diagnostic test but is used as a marker for Lyme being active. Test done by LabCorp.

  • >200 is normal
  • < 20 severe illness
  • 0-60 is seen in chronic Lyme disease
  • > 60 Lyme activity indicates improvement


  •  


    CajunGrl
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    Date Joined Mar 2009
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       Posted 7/30/2009 8:55 PM (GMT -6)   
    Lyme,

    I don't know if this will help any but my LLMD wanted to see my CD57 number closer to the 100's. I was 23 on the first test, then 43 on the second. I think it went up slightly because I started taking high doses of Vitamin C. Aren't you on C now? That may be why your number is a little higher.
    **You never know how STRONG you are....until being STRONG is the ONLY choice you have**

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    Tallison
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    Date Joined Jun 2007
    Total Posts : 417
       Posted 7/30/2009 9:23 PM (GMT -6)   
    I have heard that folks with babesia will have a higher reading on CD57 levels.  I forget exactly why.
     
    Mine (prior to treatment) was 32.  Then it went down to 18, then 15 and now 12.  I'm going the wrong way.  Although I'm not doing abx anymore.
     
    And I'm not in severe pain.  I have issues that are gnawing (achy ribs for instance).  And sleep issues (twitching and parching and chronic waking).  But during the day I feel pretty much ok (if the sleep wasn't too bad) I am functional.  But I'm still under 20.  And my first number %CD8-/CD57+ Lymphs (the number on top) is 1.
     
    I wonder why R.Stricker didn't talk about it at all today.  Was it even mentioned once in the 9 hours?  I heard the c6 peptide and a lot of talk re: PCR's...
     
    Also, I heard them mention the pneumonia vaccine antibody test for the strength of the immune system.  I had this, and mounted a good immune response.  Then how could my cd57 be so low??
     
    Sorry, for just adding more confusion into the pot..

    veromia333
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    Date Joined Mar 2009
    Total Posts : 674
       Posted 7/30/2009 11:56 PM (GMT -6)   
    Cd-57 is really a relapse predicting tool and like they said sickness indicator. I have read many articles saying it is not definitive but it is still an element in certain strains so coinfections as stated play role as well. It is so frusterating to not have something concrete.
    Isn't it.
    The line is faded not showing where Lyme came in. I became a new Mommy n my Lyme decided to show itself. Swollen elephant like knee and finger and limiting back pain. Bell's palsey, weight loss as if I had no muscle on my bones anymore. And much more text book lyme symptoms. To a Lyme doc, after alot of there is nothing wrong with you and a recommend to counceling,he said V this is Lyme. What kept me pressing on I had Lyme while I was pregnant. I know I was not infected while pregnant. I am watching her with an eagle eye. God Bless everyone. Love Veronica. Were the ones who know about Lyme not the doctors. Isnt that just mad? Backwards. Alice in wonderland.


    +Lyme
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    Date Joined Apr 2009
    Total Posts : 1304
       Posted 7/31/2009 11:38 AM (GMT -6)   
    Agreed, Veromia. It sounds like the best tool for indicating improvement and possibly when cured. (btw, how are you? Weren't you taking Amox? How's that going?)

    I have not been able to find info on the top number. And the thing is, I've seen CD57 as specific for lyme, but have also seen it discussed w/ other illnesses. And there's something about that link to CD8, but I don't understand what it is.

    Seems I've heard people call it a DNA test, but I don't find that. With all my infections and other issues (hormones, thyroid, adrenal, etc), I'd really like to know if this indicates Lyme as the problem w/ some amount of certainty. Otherwise, I've got some other kind of immunosuppressing illness. Quest WB is all I've got and I've got positive 39, so that is proof I have at least BEEN infected w/ Lyme. I find differing opinions on whether it means a live infection. I guess that depends on if one believes Lyme can resolve w/o treatment.

    I don't have a ton of faith in my LLMD right now, but that is a whole other story......
     


    RottenDog
    Veteran Member


    Date Joined Apr 2009
    Total Posts : 1013
       Posted 7/31/2009 12:18 PM (GMT -6)   
    i was asking the same thing about the CD57 test and someone posted this site. maybe it can help answer some things for you as well. http://sci.tech-archive.net/Archive/sci.med.diseases.lyme/2007-04/msg00280.html  its Everything You Wanted to Know about the Lyme CD-57 Test.
     
    this is just a small part of the post but had a lot of info on it.
     
    No one knows
    for sure why CD57+ NK cells are
    low in Lyme disease patients, but
    it is important to note that many
    disease states that are often confused
    with chronic Lyme (MS,
    systemic lupus, rheumatoid arthritis)
    are not associated with low
    CD57+ NK counts.

    The good
    news is that for most Lyme
    patients the CD57+ NK level
    increases as treatment progresses
    and health is regained.
    CD57 markers can also be
    expressed on other kinds of cells,
    including T-cells, so it is important
    to distinguish between
    CD57+ T-cells and CD57+ NK
    cells.

       RD
     
    still looking for answers.
     
    Remember that advice is free, its your choice what you do with it.  :)


    +Lyme
    Veteran Member


    Date Joined Apr 2009
    Total Posts : 1304
       Posted 7/31/2009 1:30 PM (GMT -6)   
    Thank you so much for this, RD! God bless you, with all you are suffering with, yourself!  Do we know the results of your tests yet? Please keep us posted!  I kind of see you as a kind of 'poster child' for a whopping big lawsuit against the IDSA and CDC (as well as  your DR!)

     


    RottenDog
    Veteran Member


    Date Joined Apr 2009
    Total Posts : 1013
       Posted 7/31/2009 4:41 PM (GMT -6)   
    it should take about a week or so b4 i find out about all my new tests. as for the CD57 post, i asked about it a few months ago and remembered i saved the addy. i go to almost all sites posted here. to learn all i can, as i am not very good at surfing the net..LOL

    as for going after my Drs, only one i want to be made accountable for not treating me is the ID who refused to treat me for lyme. stating i did not have lyme but a false positive test. he wouldn't look me in the eyes either, nor did he pay any attention to my list of sx i gave to him. to me this is out right negligence on his part. and he should be made well aware of it.
       RD
     
    still looking for answers.
     
    Remember that advice is free, its your choice what you do with it.  :)


    KO-LD
    Veteran Member


    Date Joined Aug 2007
    Total Posts : 887
       Posted 7/31/2009 9:14 PM (GMT -6)   
    My first CD57 was 76, but I was on Cat's Claw for 6 months for Tendinitis this was before I was diagnosed with LD (Cat's Claw is known to improve CD57 scores).  My latest CD57 was only 34 this was after 6 months of Zhang's protocol.  My first LLMD told me he likes to see the score above 180, I've read if you stop treatment before it reaches 150 you are more likely to relapse.  I am now on Buhner's protocol which includes Cat's Claw, so we shall see.
    KO
    2001 symptoms started:
    Tingling in fingers and toes both sides, not tested at that time for LD
    2007 Summer tested pos. WB, diagnosed with LD, tested neg for co-infections thru Igenex
    Abx - Doxy 100mg 2x/day for 3 weeks (before diagnosis)
    Amoxicillin 1gm 2x/day for 1 month
    Amoxicillin 1gm 3x/day with Probenecid 500mg 2x/day  5 months 
    Currently on Dr. Zhang's protocol stopped Zhang's after 6 months symptoms returned.  Started Buhner's protocol May 2009

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