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Vin
Regular Member


Date Joined Jan 2006
Total Posts : 312
   Posted 8/29/2009 8:35 AM (GMT -6)   
4 days into my zithrow/malarone/flagyl combo.   This is by far the worst the pain has been.  Wrists, knees, and ankles.  For three 3 days i am awoken by the pain and i imediately have to run to the bathroom to get my nucynta(great drug btw).   I am waiting for it to kick in so im killing some time to keep my mind off things.   This is one serious herx.  I thought they were bad before.   I am also running 100 fevers every night from 4 pm-11pm.  Its amazing how consistent it is.  Anxiety is high when i am not on pain killers.    Thank god for strong pain killers!!!
 
/Rant off. 
 
Hope everyone is fairing better than me! 
 
Vin
 
History:
UC/Chrons - Feb 2004
Panic Disorder/depression - June 08
Lyme Disease/Babesia - June 08 
Dysplastic Nevus Syndome - birth
Currently: Treating Lyme Disease
Drugs: 6mp 50 mg|Paxil 50 mg|Klonopin .25 mg|Trazodone 50 mg|WellButrin|Zithromax,Malarone,Flagyl|PRN OxyIR
 
 
 
 
 


CajunGrl
Veteran Member


Date Joined Mar 2009
Total Posts : 4717
   Posted 8/29/2009 10:44 AM (GMT -6)   
Vin,

I'm sorry your herx is so strong. I can definitely relate. I hope it eases up soon.
**You never know how STRONG you are....until being STRONG is the ONLY choice you have**

Co-Moderator Lyme Disease Forum


nefferdun
Veteran Member


Date Joined Feb 2008
Total Posts : 900
   Posted 8/29/2009 8:22 PM (GMT -6)   
When I wake up during the night with my typical arm pain, I will think of you and send you good thoughts. Hang in there!

+Lyme
Veteran Member


Date Joined Apr 2009
Total Posts : 1295
   Posted 8/29/2009 9:35 PM (GMT -6)   
Vin, I am so sorry about your pain, your herx, your fevers and your anxiety --- this all sounds so horrible! Only 1 of the above sends me to the pits! I am glad you have a strong pain killer. But does this help your fevers and anxiety??

I am not familiar w/ nucynta. Did a quick look up and see that it's an 'opiod'. So, is this a form of codeine or more like opium? And aren't they one and the same? They come from the same flower, don't they, but what is the difference? Or am I wrong?

I ask because I like codeine, but have built up a tolerance to it and it will only help for about 1 day for me. So I have wondered what else I could take if I really needed something. So far, I have lots of pains, but fortunately not severe enough to require narcotics. (my last narc was recently, for very ruthless oral surgery)

Your situation sounds pretty desperate -- even if it's a herx, shouldn't you be contacting your Doctor?

Sooooo.... I thought I might be herxing a bit, but I have nothing compared to what you describe, just mental breakdown stuff, aches, and depression/anxiety.

Please keep us posted and please tell us know about the drug questions only when you are feeling up to it, OK?
Bit 1972: Acute and chronic tonsillitis, UTI, miscarraige, appendicitis, hypoglycemia,  chronic neck pain w/ crushed vertibrae, chronic severe back pain, mitral valve prolapse, depression, resolution?
Bit Mother's Day 2007: Lyme, Babesia microti, hypothyroidism, EBV, HHV6, Parvovirus B19, low adrenals &misc other hormones, depression, anxiety, more of the above.
What don't these nasty bugs cause? 
CD57= 60, so we're in pretty good shape.
 


Vin
Regular Member


Date Joined Jan 2006
Total Posts : 312
   Posted 8/30/2009 1:42 PM (GMT -6)   
Hey guys, thanks for responding.   Codeine itself is an opiod just as the other narcotic pain killers.  They are all converted into morphine once it enters your brain.   Codeine is the weakest of the opiods.  Hydrocodon is a step up, morphine a step up, oxycodone a step up from that, then hydromorphone,oxymorphone, and fentanyl based drugs beyond.  Nucynta is completely unique.   Nothing else chemically related to it on the market, except maybe tramadol but very weakly related. 
 
+Lyme, i posted this in the chronic pain forum about nucynta.

" have been on nucynta now for a week. 50 mg three times a day, although ive taken up to 5 with excrutiating pain. Its a strong drug. Much stronger than tramadol. Doesnt feel at all like tramadol although its dual action like tramadol. I was off percosets for about 3 weeks as my pain was significantly less so my tolerance was reset(although i dont think this drug is cross tolerant). Takes about 20-40 minutes to kick in but it definately hits you pretty good right away...unlike the slower come on of oxy. I'd describe it as having an equivalency of nucynta 50mg = oxy 5 mg as per analgesia. The pain melts away very effectively and you will get pretty high off of it. It is sedating for the first hour - 2 hours..and then it wears off and you feel almost perfecty normal but pain free for the next 3 hours. Afterwards your pain will start creeping back in. I believe its exactly as effective today as it was last sunday. even with percoset/oxy, i notice some tolerance even after a week. I also don't find i crave the drug as much as oxy. And the come down off this drug doesn't appear as nasty. I am going to keep with it and hopefuly be able to write an update over the next month or so and note tolerance and addiction potential.

I think the bad rap its gotten is due to the cross tolerance issue. I dont believe there is cross tolerance between this drug and traditional opiates. So I believe when a person who has been on pain meds for a substantial amount of time switches to this drug, they go into withdrawal frm their original drug. I took a few weeks off of percoset so i came in with clear baseline.

Good:
--Very effective at pain reduction. As soon as you feel it, watch out, hits hard and fast and pain is GONE.
--Sense of well being/euphoria especially after the 1-2 hour initial hit. The first 1-2 hours are very relaxing and you will be high(at least for the first week). After, you begin to come too again, think clearly, have energy, yet pain is still completely gone.
--Seems slower at building tolerance than other opiates. I'll report back by next week as that will give me a clear understanding of tolerance as by the second week i do have a tolerance on most opiates ive been on.
--No itching
--Not cross tolerant(imo a good thing because you can switch to a different drug now without having to start at high doses)
--Less physical craving for the drug. With oxy, after about a week, I find my mind wanting the drug and its a battle to keep on schedule. With this drug, i believe becasue of the less tolerance building, i dont feel the need to want more.
--don't really have a hangover but can be tricky to tell with my condition

Bad:
--At first can hit too hard. Make sure you try it on a day off initially.
--more nausea. Ive noticed on about 100 mg you get decent nausea for about 30 minutes.

Thats all I can think of right now. I'll post more as I learn more. Questions let me know.

I think its a great drug IMO at this point.

Vin
"

And for your question, I have been in touch with my doctor and he said to expect this. I was very very sick the previous few weeks and then i stopped antiobiotics for a few days and ended up even worse! We both believe this to be a necessary evil. I am just quite sick and this goes with the turf. The nucynta has been a lifesavor. I function much better on it than vicoden, percoset, oxy.  Tried Tramadol in the past, the ER version... it took some of the pain edge away in the beginning but just isn't strong enough for me.  After a few days you really don't get too high from nucynta anymore, and since it acts like an antidepressant also, my energy level and mind is quite a bit more clear.

Today I am feeling a bit better, i didn't wake up early from pain!! It was creeping in slowly but i popped a nucynta and feeling better. So this is the first day without excruciating pain in a few weeks. Have to see if my afternoon fever breaks also.

Hope you are all having a nice Sunday :)

Vin


History:
UC/Chrons - Feb 2004
Panic Disorder/depression - June 08
Lyme Disease/Babesia - June 08 
Dysplastic Nevus Syndome - birth
Currently: Treating Lyme/Babs
Drugs: 6mp 50 mg|Paxil 50 mg|Klonopin .25 mg|Trazodone 50 mg|WellButrin|Zithromax,Malarone,Flagyl|PRN Nucynta/Percoset
 
 
 
 
 

Post Edited (Vin) : 8/30/2009 12:48:22 PM (GMT-6)


Turquoise Sky
Regular Member


Date Joined Apr 2009
Total Posts : 250
   Posted 8/30/2009 2:24 PM (GMT -6)   
Wow! The only time my pain was that severe was for two and a half weeks in 2005, before I knew what was causing it. None of the pain meds or muscle relaxers touched the pain, which was all in my neck from the swolen lymph nodes. With the relapse, there was pain all over, but more tolerable this time. I couldn't imagine being in that much pain all the time! Glad that you have some relief!

KeepHope
Regular Member


Date Joined Oct 2008
Total Posts : 222
   Posted 8/30/2009 5:19 PM (GMT -6)   
I have been on morphine for 10 years now?
I am interested in what this drug is? nucynta
I am not getting much relief anymore but it takes a lot MORE Of what I am taking or
Uping it .. to get some relief and I just hate having to go there.

How and where can I find our more?

Glad its working for you
Thanks

Vin
Regular Member


Date Joined Jan 2006
Total Posts : 312
   Posted 8/30/2009 7:10 PM (GMT -6)   
talk to your GP or pain dr about it. you can google nucynta and read about it. not many reviews of it out there yet. IMO its great.
History:
UC/Chrons - Feb 2004
Panic Disorder/depression - June 08
Lyme Disease/Babesia - June 08 
Dysplastic Nevus Syndome - birth
Currently: Treating Lyme/Babs
Drugs: 6mp 50 mg|Paxil 50 mg|Klonopin .25 mg|Trazodone 50 mg|WellButrin|Zithromax,Malarone,Flagyl|PRN Nucynta/Percoset
 
 
 
 
 

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