No, but I had ear pressure, pain, and increased ringing on Zithromax. The common thread is that they both treat babesia. It's possible that you are having a herx reaction. I don't recall that babesia causes ear trouble. I thought that was more of a Lyme or bartonella thing, but I could be wrong. I would suggest that you contact your doctor. He/she may have you back off or increase more slowly to see if you continue to experience pain. The problems with Zithromax faded after a while. I've had my hearing checked, and I have not had any hearing loss.