It's been awhile since I've done IV Rocephin, but I'll give you my two-cents' worth in random bullet order...
* I have mainly neurological Lyme, not much of a pain issue, so if you're the opposite you may have a different experience.
* Rocephin did *wonders* for me...but it worked *so* well that I couldn't tolerate it for long and had to stop it. I think I only did the treatments for two or three weeks.
* I immediately felt much *better* across the board on all of the wierd neurological and emotional symptoms I had had.
* The reason I had to stop wasn't because of an exacerbation of my usual symptoms as you might expect from a herx. I.e., I didn't begin to feel *more* depressed, more neurologically blasted, etc. On the contrary, I actually felt those things delightfully retreating even when I couldn't tolerate the Rocephin.
* What became intolerable is that I began to feel very -- very -- "heavy-headed," as if the weight of the world was trying to drain out of my head through a drinking straw. It got to the point where I felt like a 300 pound man was trying to press me down into the ground with his work boot. I stopped the treatment out of a sheer feeling of needing to come up for air. That treatment was ordered by a wonderful local doc who knew the basics of what to do but probably didn't have the finesse to discern that my liver just couldn't handle all of the toxins that were being released. One problem I've had throughout Lyme treatment -- and gradually gotten smarter about dealing with -- is that I've had a problem tolerating things and have had to often start with small doses of antibiotics and build up. Also, I've discovered that I have a slow Phase II liver metabolism and a relatively fast Phase I metabolism. That can cause a train wreck of sorts where toxins pile up and can't get processed through Phase II fast enough. A supplement called Calcium D-Glucarate has really helped with that. So, I'm hoping that when/if I ever do IV Rocephin again I'll be able to a) be more strategic about starting at a smaller dose and building up and b) have a liver that's more capable of processing the issues that it creates because of taking and having taken D-Glucarate.
* I'm pleased to report that after stopping the Rocephin and "getting the man's boot off my head" I felt wonderfully better...for several months! I went back to a lesser, oral antibiotic, so that several-month-long state of success wasn't just held on its own, but it seems the Rocephin did hit the nail on the head in a big way. My doc and I just didn't have the finesse at the time to know how to navigate the dosing, nor did I have the liver to be able to handle it very well.
* I've also recently learned that my blood is hypercoagulated (too thick) which could have been part of the problem, too.
I wish you all the best if you're about to embark on IV Rocephin treatment. I imagine it will do you a world of good, and I hope you'll be able to tolerate it and navigate the dosing and usage of it to its full benefit. I hope this helps you to do so. :)