Anybody know about C4a levels?

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Sassy1014
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Date Joined Jun 2010
Total Posts : 81
   Posted 12/27/2011 8:45 AM (GMT -6)   
I got my C4a levels drawn and they were low...609. Has anybody studied what these numbers actually mean? Thanks a lot. Happy and healthy 2012 you all.

achievinggrace
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   Posted 12/28/2011 3:58 AM (GMT -6)   
Bump
Co-Moderator Lyme Disease Forum

1bitten2xshy
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Date Joined Jun 2007
Total Posts : 847
   Posted 12/28/2011 9:32 AM (GMT -6)   
Did you have your C3A tested as well? Do you know if it was sent thru National Jewish Labs in Denver, CO?

Sassy1014
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Total Posts : 81
   Posted 12/28/2011 3:29 PM (GMT -6)   
No and no. Labcorp did it. Didn't do my C3as.

borderlyme
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Date Joined Jul 2011
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   Posted 12/28/2011 10:27 PM (GMT -6)   
Hi, Sassy! I found this article which explains a little about C4a and C3a.

http://www.publichealthalert.org/Articles/gingersavely/C3a%20and%20C4a.htm

Basically, my interpretation is that the numbers monitor the degree of infection in your body. My doctor hasn't been testing these in me - although I looked back at old bloodwork from another doctor and my C4a was upwards of 8000. My current doctor has been testing C4 which is within normal range, but I'm not sure if these are the same, or similar, or not related at all! There's my 2 cents
:)
www.publichealthalert.org/Articles/gingersavely/C3a%20and%20C4a.htm

Post Edited By Moderator (achievinggrace) : 12/29/2011 7:11:15 AM (GMT-7)


Sassy1014
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Date Joined Jun 2010
Total Posts : 81
   Posted 12/29/2011 8:42 AM (GMT -6)   
Thanks for the article. It explained a lot except for me. LOL. I almost think that Lymes might have triggered something else. I think one of which is my allergies so I am going back to get tested again. I had shot 15 years ago for 5 years. I think they have returned. I am sure Lymes helped with this. I just find is weird that one year on heavy duty drugs and I have not felt any differently. Thanks!

achievinggrace
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   Posted 12/29/2011 9:11 AM (GMT -6)   
borderlyme -- just added the hyperlink
Co-Moderator Lyme Disease Forum

Scarlet Grace
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Date Joined Nov 2011
Total Posts : 110
   Posted 12/30/2011 11:28 AM (GMT -6)   
I have wondered about C4 levels too. Mine were 246 ng/mL.

Sassy1014
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Date Joined Jun 2010
Total Posts : 81
   Posted 12/30/2011 12:45 PM (GMT -6)   
My doctor in DC told me he looks at the levels as how you are detoxing. Mine came down a bit from my last blood work and he said that was good. Funny, I never read it that way.

LymieAngel
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Date Joined Sep 2011
Total Posts : 466
   Posted 12/30/2011 4:14 PM (GMT -6)   
my doc told me that c4a was the measure of inflammation in your body.....i think the range goes to like 2500...and lyme will make it skyrocket.....especially if u have have joint probs and IBS symptoms...cause anything that is allowed to swell from infection...will with lyme....i take a supplemement to reduce inflammation naturally and some people will take naperxen....i take both
getting better.......

Scarlet Grace
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Date Joined Nov 2011
Total Posts : 110
   Posted 12/30/2011 4:35 PM (GMT -6)   
So what does it mean if your numbers are really low? My doctor had said one of my tests showed signs of inflammation, and I thought she said it was the C4A, but it sounds like my number was really low...

Sassy1014
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Date Joined Jun 2010
Total Posts : 81
   Posted 12/30/2011 4:44 PM (GMT -6)   
Good question. That's what I want to know too.

LymieAngel
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Date Joined Sep 2011
Total Posts : 466
   Posted 12/30/2011 9:20 PM (GMT -6)   
rather your number is high or low.....it means u have inflammation......i think its suppose to be in the 20's or 30's to be considered normal yours was 600? thats measurable inflammation....mine was 6800 but i have had lyme for around 20 yrs with no treatment
getting better.......

Sassy1014
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Date Joined Jun 2010
Total Posts : 81
   Posted 12/30/2011 9:27 PM (GMT -6)   
Thanks Angel.

yazzer
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Date Joined Jun 2011
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   Posted 12/31/2011 5:23 PM (GMT -6)   
My complement 3a was 110.5 (ref: 54-202) and my 4a was 251.2 (ref: 0-650). My CD57 was 235. Results through LabCorp. All these are GOOD but I was till laced with Lyme (and am still working through it). I have reactivated EBV and my TGF-b1 (human trans. growth beta 1) was 10460 (ref: 344-2382) so that baby was off the charts. The artical on C3a/4a was a good one!

mlcc2
New Member


Date Joined Feb 2012
Total Posts : 9
   Posted 2/9/2012 6:05 AM (GMT -6)   
Just joined the forum this morning. Anyone have or had a C4a as high as 71,000? What did you do to get the level down? I must admit, I feel lousy. My hearing has dramatically been reduced at age 44 and my neurological symptoms change frequently. My C3a is at 300. We did have mold removed from the house which consisted of Penicillium, Aspergillius and Stachybotrys. House was re-tested and clear. Recent rheumatology labs indicated no inflammation in the body. I had an Ignex panel done several months ago but the ordering dsoctor claims the results are vague to indicate mold or lyme disease. Is their one test or tests that can determine whether or not it's mold or lyme causing me this grief? Any input would be greatly appreciated!

Sassy1014
Regular Member


Date Joined Jun 2010
Total Posts : 81
   Posted 2/9/2012 7:21 AM (GMT -6)   
Hi new member. Sorry you are having problems. www.survivingmold.com is a good site for you to get started on. This doctor really focuses on toxic mold problems. Give it a try.

mlcc2
New Member


Date Joined Feb 2012
Total Posts : 9
   Posted 2/12/2012 9:40 PM (GMT -6)   
Thank you for the great info Sassy 1014!

Sassy1014
Regular Member


Date Joined Jun 2010
Total Posts : 81
   Posted 2/12/2012 10:02 PM (GMT -6)   
You are welcome. Good luck. Feel better.

mlcc2
New Member


Date Joined Feb 2012
Total Posts : 9
   Posted 2/28/2012 1:56 AM (GMT -6)   
Anyone able to read Ignex Western Blot tests? I cannot get the ordering physician to interpret mine. Any help would be greatly appreciated!!

Ignex panel results were as follows:



(Lyme IgM Western Blot)

IGENEX IGM RESULTS NEGATIVE
CDC/NYS RESULTS NEGATIVE

18kDa -
**23-25 kDa -
28kDa -
30kDa -
**31kDa -
**34kDa -
**39kDa -
**41kDa IND
45kDa -
58kDa -
66kDa -
**83-93kDa -


(Lyme IgG Western Blot)

IGENEX IGG RESULTS NEGATIVE
CDC/NYS RESULTS NEGATIVE

18kDa -
**23-25 kDa -
28kDa -
30kDa -
**31kDa -
**34kDa IND
**39kDa IND
**41kDa ++
45kDa -
58kDa -
66kDa -
**83-93kDa -

Summer3
Veteran Member


Date Joined Nov 2011
Total Posts : 1017
   Posted 2/28/2012 4:53 AM (GMT -6)   
Hi Mlcc2,

I'm not medically trained, but I have done some research on Western blot bands for Lyme. It looks like you have band 41 showing up positive. This band is common in Lyme but it can also is positive for other conditions as well.

I have found an article that discusses band 41. http://stevensponauglewordpress.com/?p=703

Generally it shows up early in a Lyme infection, but that's not always the case. Testing negative doesn't necessarily mean that you do not have Lyme. If you have a lot of Lyme symptoms, it's best to be evaluated by a LLMD despite the test results.

mlcc2
New Member


Date Joined Feb 2012
Total Posts : 9
   Posted 2/28/2012 9:01 PM (GMT -6)   
Thank you very much Summer3 for your reply.. I have a tentative appointment set for a LLMD in Northern California in March.
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