Good question on the timing of dosage... I think a lot has to do with individual tolerance
I too, was on Tindamax for 3 months and in the beginning I had to plan out when i should take all 4 antibios. I made "special" plans to take the cyst buster when I could lay low for two consecutive days because at first it really wiped me out. The Tindamax is wicked stuff but it works. I did not like this stuff but I know it worked for me. then I was having problems with nervousness/irritability from Tindamax and Minocycline --- so what was suggested was for my second daily dosage take all antibios earlier in the evening with food and zofrin (for nausea). Adjustments in the timing during the day helped, as well as taking with food.
I guess to keep it short...it depends on the individual.
Now, I am beginning my new mix of antibios which includes rifampkin,doxy and clarithromycin. No more Tindamax for awhile (hopefully for good). I hope I can tolerate this mix...