MTHFR C677T Mutation

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samjones
Regular Member


Date Joined Jan 2013
Total Posts : 355
   Posted 1/24/2013 9:58 PM (GMT -6)   
Hi all,
 
Has anyone heard anything about this? It is something in a gene mutation that makes eliminating lyme very difficult.
Undiagnosed lyme, bartonella, anaplasmosis, babs for 25 yrs with a 16 year old that I passed lyme and coninfections to through pregnancy. We both began treatment 1/6/11. Still treating. Daughter will be a success story hopefully in 2013!

nan777
Regular Member


Date Joined Aug 2012
Total Posts : 343
   Posted 1/24/2013 11:21 PM (GMT -6)   
Hi samjones!

I just had this test..it is a blood test and it came out negative for me for the mutations. It has to do with methylation and b vitamins and folic acid etc, being processed correctly..and there is likely more to it than that, but that is the general understanding I have.

I have never heard of it making it hard to eliminate lyme..or harder than anything else, in any case. My docs seem to be looking at it as more info and then they would treat accordingly.

I have a friend with fatigue issues who is being treated for it and it has helped. (he does not have lyme).

Hope this helps! I would get the test and go from there..I think it is important information.

Nan
CFS for 17 years, diagnosed with chronic lyme 3 years ago. Hansa Clinic Oct 2012-- Now 70% well. Lymogen, Yeast-ease, Paragen, Virogen, Etheric delivery glutathione, Vit C with R-Lipoic Acid, L Ornithine aspartate, cortef, thyroid, lumbrokinase, glandulars, homeopathics. FIR sauna, footbath, acupuncture, colonics, chiroopractic, gluten/sugar/refined carb free diet. CCSVI, OSB.

Razzle
Veteran Member


Date Joined Aug 2007
Total Posts : 4027
   Posted 1/24/2013 11:30 PM (GMT -6)   
Yes, this mutation can cause a person to have lowered immunity, and also can cause a person to have difficulty detoxifying during herxheimer reactions.

Compensation is easy, though (relatively)... Requires avoidance of folic acid as much as you can (usually only found in pills and fortified foods such as bread or cereal), and instead take a supplement of methylfolate (5-methyltetrahydrofolate) and also need Vitamin B12 - preferrably the hydroxy-B12 or methyl-B12 and not cyano-B12.

Start with small doses of the methylfolate, because when you first begin to compensate for this MTHFR mutation (which causes an inability to convert Folic Acid to methylfolate, thus stopping the production of glutathione), all the stored up toxins can suddenly start to get released...

This causes a toxicity reaction that can be a bit uncomfortable... thus the need to start slowly and then slowly increase.

Other supporting supplements include:

Zinc
B-Complex (specifically, the active forms of the B vitamins, such as methyl-B12, methylfolate, P5P, etc.)
Vitamin C
Magnesium
Iron (if deficient; don't take supplemental iron if not deficient)
Selenium
Vitamins D, A, E
Other antioxidants (pycnogenol, etc.)

And may also need to support the liver with Milk Thistle.

Also, if one has sulfur/sulfite sensitivity, it is likely there are other methylation cycle genomic variants (mutations) that need to be dealt with prior to initiating support for the MTHFR mutation.

The only test I know of that looks at all the mutations is Dr. Yasko's Comprehensive Methylation Panel. See www.holisticheal.com/ for more info.
-Razzle

Chronic Lyme, Bart., Gluten & Sulfite Sensitivity, Many Food/Inhalant/Medication/Chemical Allergies & Intolerances, Asthma, Gut dysmotility & non-specific inflammation, Lupus, Osteoporosis, etc.; G-Tube
Meds: Flagyl, Domperidone, Claritin, Andrographis & other herbs, homeopathy, supplements, etc.

nan777
Regular Member


Date Joined Aug 2012
Total Posts : 343
   Posted 1/24/2013 11:53 PM (GMT -6)   
razzle and sam: my LL doc order a simple blood test to test for the mutations..both C677T and A1298C.

I just looked at Yasko's panel.it tests for many more variants than what I had done.

Not sure when it would be indicated to do the more comprehensive panel vs. the more simple test I had done.
CFS for 17 years, diagnosed with chronic lyme 3 years ago. Hansa Clinic Oct 2012-- Now 70% well. Lymogen, Yeast-ease, Paragen, Virogen, Etheric delivery glutathione, Vit C with R-Lipoic Acid, L Ornithine aspartate, cortef, thyroid, lumbrokinase, glandulars, homeopathics. FIR sauna, footbath, acupuncture, colonics, chiroopractic, gluten/sugar/refined carb free diet. CCSVI, OSB.

Razzle
Veteran Member


Date Joined Aug 2007
Total Posts : 4027
   Posted 1/25/2013 1:13 AM (GMT -6)   
Sulfur intolerance or sulfite sensitivity is one indication of more issues besides just MTHFR.

Autism or autistic spectrum type issues would be another.

And response to the MTHFR protocol itself - if you don't get better but rather get steadily worse from the methylfolate and methyl-B12...that would be another indication for further testing.

Personally (I have no financial connections with Dr. Yasko, her lab or her tests), I prefer to know all the issues around methylation variants first before treating, because the treatment protocol depends on knowing which mutations one has before you start treatment (there is a specific order in which mutations must be dealt with, otherwise one risks making one much more ill...).
-Razzle

Chronic Lyme, Bart., Gluten & Sulfite Sensitivity, Many Food/Inhalant/Medication/Chemical Allergies & Intolerances, Asthma, Gut dysmotility & non-specific inflammation, Lupus, Osteoporosis, etc.; G-Tube
Meds: Flagyl, Domperidone, Claritin, Andrographis & other herbs, homeopathy, supplements, etc.

Shabbychic
Regular Member


Date Joined Jul 2012
Total Posts : 395
   Posted 1/25/2013 8:43 AM (GMT -6)   
Razzle, you are amazing. You are so smart, it's astounding. How do you KNOW all of this stuff?? Will you come with me to my next doctor's appt. : )

TICKLEDPINK
Veteran Member


Date Joined Jul 2012
Total Posts : 899
   Posted 1/25/2013 8:58 AM (GMT -6)   
Hey,Shabbychic

I'm glad you said that about Razzle,I've been thinking the same thing for ages.

She's like a walking,talking encylopedia when it comes to Lyme and Co-------amazing!!!!!

samjones
Regular Member


Date Joined Jan 2013
Total Posts : 355
   Posted 1/26/2013 1:40 AM (GMT -6)   
That is very interesting. I need to take B12 shot because my body can't absorb it through my gut. And I have a very difficult time detoxing. I have gone into sepsis while in the beginning of my treatment and been toxic another 3 times, then i had that cytokine storm. I wonder if that is all related. I was going to have my doctor run the other test, HLA from labcorp, maybe I should have him run this too.

What do I ask for when suggesting this test to my doctor?
Undiagnosed lyme, bartonella, anaplasmosis, babs for 25 yrs with a 16 year old that I passed lyme and coninfections to through pregnancy. We both began treatment 1/6/11. Still treating. Daughter will be a success story hopefully in 2013!

Razzle
Veteran Member


Date Joined Aug 2007
Total Posts : 4027
   Posted 1/26/2013 5:59 AM (GMT -6)   
Aw, shucks you guys!!! blush blush I'm not really an encyclopedia (though my Mom would agree with you that I am, LOL!)...just have done a ton of research to figure out why I've been so darn sick for so long...and in the process, some of it stuck in the ol' noggin...

Testing:

The Yasko Methylation Panel doesn't require a doctor's order. You can order the test kit from www.holisticheal.com/dna-methylation-pathway-test-kit.html

To just get MTHFR tested, you can ask your doctor for a lab slip for pretty much any regular lab (such as LabCorp or Quest) and have him mark on the lab slip "MTHFR DNA testing" and the lab should be able to figure it out. See labtestsonline.org/understanding/analytes/mthfr/tab/test for more info.

If you do go to a regular lab for the MTHFR test, make sure they are going to look for both C677T and A1298C mutations, as both can cause problems with Folic Acid conversion, detoxing, and other issues (some relate this mutation with increased risk of heart attacks and blood hypercoagulability).

General info:

For more info on methylation in general, see:

mthfr.net/
www.heartfixer.com/AMRI-Nutrigenomics.htm
www.dramyyasko.com/
www.anma.org/pdf/Methylation_by_Dr_Jack_Tips_Complete_and_Illustrated_Article.pdf

For Rich Van Konyenburg's simplified methylation protocol, see livewithcfs.blogspot.com/2012/05/dr-konynenburgs-simplified-methylation.html -- but be aware that other methylation defects may cause this protocol to be too intolerable, and those other defects may need to be dealt with first before the simplified protocol can be initiated.

For clarity's sake, methylation genomic variants (mutations) are not the same thing as Dr. K's HPU/KPU (which is basically a severe zinc deficiency), nor is it the same thing as Dr. S's HLA-DR testing.

These are all different tests, that look at different reasons why a person would potentially have difficulty with detoxification and with treating Lyme/coinfections effectively...and all come with their own separate tests.
-Razzle

Chronic Lyme, Bart., Gluten & Sulfite Sensitivity, Many Food/Inhalant/Medication/Chemical Allergies & Intolerances, Asthma, Gut dysmotility & non-specific inflammation, Lupus, Osteoporosis, etc.; G-Tube
Meds: Flagyl, Domperidone, Claritin, Andrographis & other herbs, homeopathy, supplements, etc.

Post Edited (Razzle) : 1/26/2013 4:04:07 AM (GMT-7)


samjones
Regular Member


Date Joined Jan 2013
Total Posts : 355
   Posted 1/26/2013 2:56 PM (GMT -6)   
Thank-you so much for that razzle!
Undiagnosed lyme, bartonella, anaplasmosis, babs for 25 yrs with a 16 year old that I passed lyme and coninfections to through pregnancy. We both began treatment 1/6/11. Still treating. Daughter will be a success story hopefully in 2013!
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