Gabapentin potency over time

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Rikky1
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Date Joined Jun 2015
Total Posts : 2213
   Posted 3/20/2017 7:01 PM (GMT -6)   
There was a recent thread on Gabapentin that didn't go too much into this particular aspect of it. Does your body get used to it at a certain dose and you're essentially forced to take higher doses over time to get the same result from it? I know this is true for quite a few psychotropic drugs so wondering if the neurotropic drugs function the same way?

I'm asking because when I started this medication I was doing really well at first and even after doubling it its like I never took it as my symptoms are back with a vengeance. Thanks.

bluelyme
Veteran Member


Date Joined Nov 2015
Total Posts : 4030
   Posted 3/20/2017 7:11 PM (GMT -6)   
I hear that ..my uncle is at 900mg and other opiods for his spinal disingration (probably lyme)

Girlie
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Date Joined May 2014
Total Posts : 22762
   Posted 3/20/2017 7:33 PM (GMT -6)   
I know someone who was on Lyrica (different, but similar)...and she titrated up...and the stayed...and it continued to work for a couple years...I'm not in touch with her anymore...so not sure now.
Moderator, Lyme Forum
Symp started April/2013; Buhner's Lyme May 15-July24/14; Igenex pos. July 3/14
Doxy: July 4-Aug.24/14;Zithro July26-Aug24/14; Amox + Proben. Aug. 29/14;
added biaxin Sept. 26/14
Disc. amox,added Ceftin Nov. 20th.;
Disc. biaxin added Buhner bart herbs Dec/14;Jan/15 pulsing Tinda (w/ Ceftin);
Abx/herb break Apr-July/15; July-mino; Aug. added Rif;
Nov./15 mino - to biaxi

Girlie
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Date Joined May 2014
Total Posts : 22762
   Posted 3/20/2017 7:33 PM (GMT -6)   
Rikky - maybe it's because you just aren't on a high enough dose?
Moderator, Lyme Forum
Symp started April/2013; Buhner's Lyme May 15-July24/14; Igenex pos. July 3/14
Doxy: July 4-Aug.24/14;Zithro July26-Aug24/14; Amox + Proben. Aug. 29/14;
added biaxin Sept. 26/14
Disc. amox,added Ceftin Nov. 20th.;
Disc. biaxin added Buhner bart herbs Dec/14;Jan/15 pulsing Tinda (w/ Ceftin);
Abx/herb break Apr-July/15; July-mino; Aug. added Rif;
Nov./15 mino - to biaxi

madisongrrl
Regular Member


Date Joined Oct 2016
Total Posts : 214
   Posted 3/20/2017 7:50 PM (GMT -6)   
Yes you can habituate to gabapentin or Lycra. Some people have maxed out on gabapentin after 5 years (3600mg) and had to switch to Lycra. But these are people with serious cases of full body neuropathy and it doesn't happen to everyone.

I have a pretty bad case of neuropathy myself. I'm a full body burner and I've been on gabapentin for 3 years and have been holding tight at 2400mg. But also doing things to reduce inflammation, which helps as well.

Post Edited (madisongrrl) : 3/20/2017 8:48:48 PM (GMT-6)


Girlie
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Date Joined May 2014
Total Posts : 22762
   Posted 3/20/2017 7:55 PM (GMT -6)   
madisongrrl - is that 1200 mg 3X daily...is that how you take it...or 1800 2X daily?


So, how does someone know when they can go off it...just try it and see if the nerve pain comes back?

I guess you titrate down, as well?
Moderator, Lyme Forum
Symp started April/2013; Buhner's Lyme May 15-July24/14; Igenex pos. July 3/14
Doxy: July 4-Aug.24/14;Zithro July26-Aug24/14; Amox + Proben. Aug. 29/14;
added biaxin Sept. 26/14
Disc. amox,added Ceftin Nov. 20th.;
Disc. biaxin added Buhner bart herbs Dec/14;Jan/15 pulsing Tinda (w/ Ceftin);
Abx/herb break Apr-July/15; July-mino; Aug. added Rif;
Nov./15 mino - to biaxi

OptimisTick
Regular Member


Date Joined Jan 2016
Total Posts : 59
   Posted 3/20/2017 8:00 PM (GMT -6)   
I've been told by my pharmacist not to take magnesium and calcium supplents/food within 2 hrs of taking gabapentin as it binds to the drug reducing its efficacy. (I also found out pregnenolone effects it too)

I have been on the same dose for 3 years and have not needed to increase it when I follow the above.

And as Girlie said, you may not be at your optimum dose yet.

Girlie
Forum Moderator


Date Joined May 2014
Total Posts : 22762
   Posted 3/20/2017 8:01 PM (GMT -6)   
Rikky - are you taking the Gabapentin in the evening? close to Magnesium?

Thanks for posting that Optimistik - if I do the Gaba - I will make sure it's not near those.
Moderator, Lyme Forum
Symp started April/2013; Buhner's Lyme May 15-July24/14; Igenex pos. July 3/14
Doxy: July 4-Aug.24/14;Zithro July26-Aug24/14; Amox + Proben. Aug. 29/14;
added biaxin Sept. 26/14
Disc. amox,added Ceftin Nov. 20th.;
Disc. biaxin added Buhner bart herbs Dec/14;Jan/15 pulsing Tinda (w/ Ceftin);
Abx/herb break Apr-July/15; July-mino; Aug. added Rif;
Nov./15 mino - to biaxi

Rikky1
Veteran Member


Date Joined Jun 2015
Total Posts : 2213
   Posted 3/20/2017 8:12 PM (GMT -6)   
i'm on 300mg AM and 300mg PM. i take my magnesium a good 4-5 hours away from the gaba. i can go to 2x this amount and probably will just wondering if i'm chasing my tail with losing its effectiveness after a short amount of time.

by the way i hate being on this stuff. heck i hate being on any of these nasty meds but its necessary as we all know.

was wondering also whether 2x or 3x a day makes any difference. i don't take this for sleep (sleep has always been good except when i get sharp chest pains but that's seldom these days). i need it to get through the day. i also notice it starts to wear off around 2 hours before my PM dose.

so 300mg 3x/day or 600mg AM, 300mg PM and see how i do? decisions decisions ;o)

OptimisTick
Regular Member


Date Joined Jan 2016
Total Posts : 59
   Posted 3/20/2017 8:35 PM (GMT -6)   
I take it 3x/day, and I think most of us know it's a pain trying to time abx and supplements with everything eyes Plus I still eat some dairy, so I have to plan the gaba around that too.

I hate having to take this as well, but it works (for me,) so I try to take the absolute minimum I can get away with and still have it work. That's one of the reasons I take 3x rather than 2x day (even though food wise it would be easier, lol!)

madisongrrl
Regular Member


Date Joined Oct 2016
Total Posts : 214
   Posted 3/20/2017 8:53 PM (GMT -6)   
Girlie said...
madisongrrl - is that 1200 mg 3X daily...is that how you take it...or 1800 2X daily?


So, how does someone know when they can go off it...just try it and see if the nerve pain comes back?

I guess you titrate down, as well?


Sorry, I fixed my post above (typo). Some people I know take 3600mg (not me, not yet)....

I used to take 3200 mg, now I take 2400 mg. I space out 3 doses of 800 mg tablets per day.

You can slowly titrate down on gaba....most likely you will get an uptick of symptoms initially. But then you hang on for a little while and see how you feel. The key point is to titrate up or down SLOWLY....

Girlie
Forum Moderator


Date Joined May 2014
Total Posts : 22762
   Posted 3/20/2017 9:33 PM (GMT -6)   
madisongrrl - So you've gone down in your total dose - is that because your neuropathy has gotten better over time with treatment?

(I hope so)
Moderator, Lyme Forum
Symp started April/2013; Buhner's Lyme May 15-July24/14; Igenex pos. July 3/14
Doxy: July 4-Aug.24/14;Zithro July26-Aug24/14; Amox + Proben. Aug. 29/14;
added biaxin Sept. 26/14
Disc. amox,added Ceftin Nov. 20th.;
Disc. biaxin added Buhner bart herbs Dec/14;Jan/15 pulsing Tinda (w/ Ceftin);
Abx/herb break Apr-July/15; July-mino; Aug. added Rif;
Nov./15 mino - to biaxi

Starlight*
Regular Member


Date Joined Apr 2015
Total Posts : 45
   Posted 3/21/2017 8:10 AM (GMT -6)   
I was told 900mg is a mouse dose for chronic illness. I think most Lyme doctors have a game plan of going up in dosage over time so I would speak to your doctor. You have to absolutely find the right dose for you. There are other neurological pain killers that your doctor can combine alongside the gabapentin when you are at maximum dosage. For some people gabapentin is enough (once at the right dose) for others effectiveness wears off and you can combine meds or swap.

Traveler
Forum Moderator


Date Joined May 2007
Total Posts : 35184
   Posted 3/21/2017 8:43 AM (GMT -6)   
That's what happened to me on Gabapentin. I maxed out the dose at 3600 or 3800 mgs daily and was switched to Lyrica and Lyrica didn't help me at all. Gabapentin did help me for about the first 4 years though.
Herb only treatment for Lyme & Bart ended 12/11 - no active symptoms for 2 yrs -Herb only treatment for Babesia ended 12/12
www.healingwell.com/community/default.aspx?f=30&m=2977364
Had Lyme, Bart, Babs, RMSF, Ehrlichia, Myco, Anaplasmosis, EBV
New Lyme case 8/2014 - Healed 1/31/15 - unknowingly had Asymptomatic Babs and Asymptomatic Bart, being treated now though (2/2016)

Laker7491
Regular Member


Date Joined Aug 2015
Total Posts : 241
   Posted 3/21/2017 11:54 AM (GMT -6)   
I have been on 400 mg of Gabapentin for about 12 years. Unfortunately, instead of trying to figure out why I had neuropathy in my mid-forties they just covered up the symptoms.

I've probably had Lyme Disease for quite some time. When my Lyme Disease reared it's ugly head again three years ago I had to increase the dosage. Right now I am up to 1800 mg and if it doesn't help I add one more 800 mg. There are times when I can reduce the amount. I am using a rife machine and I think when one of the frequencies hits something it will flare up my neuropathy.

I also have medical marijuana which I use when the pain is over the top and nothing else helps. I hate to use it because it really doesn't take my pain away, it just relaxes me and then I fall asleep. I also have kratom which is legal in our state. It stopped working after about a year. It tastes awful but did help for awhile so it could be another option.

My doctor wanted to switch me to Lyrica but I declined. I know it causes weight gain and I have enough trouble with that as it is.

So it does help me, I really can't recall if worked better when I first started taking it or not since it's been so long. I just pray I can stop taking it all together one day.

madisongrrl
Regular Member


Date Joined Oct 2016
Total Posts : 214
   Posted 3/21/2017 7:18 PM (GMT -6)   
Girlie said...
madisongrrl - So you've gone down in your total dose - is that because your neuropathy has gotten better over time with treatment?

(I hope so)


I'm not sure that my neuropathy has gotten better. I'm on abx and they have an anti-inflammatory effect on neuropathy. So once I'll stop abx, then I'll really know what is going on.

My neuropathy is so insidious that I don't have to shave my legs anymore. I just get a few stray hairs that randomly grow.
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