Standard two-tier lyme test has a false negative rate of 74.9%

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mpost
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Date Joined Feb 2015
Total Posts : 1064
   Posted 9/18/2017 2:40 PM (GMT -6)   
/www.ncbi.nlm.nih.gov/pmc/articles/PMC5391870/

"False-negative results can impact diagnosis and treatment of LD, and this study indicates that for early-stage disease false-negative results are 66.8% for a single-stage test increasing to 74.9% for the two-tier test.

By comparison, HIV testing results in 1.4% false negatives for the worst-case single test and 0.095% false positives with sensitive tests used with a two-step methodology. LD testing in early-/acute-stage disease generated 56 times more false-negative test results than HIV testing, and when neurological/arthralgia symptoms were present, LD testing generated ~180 times more false-negative test results than the two-step HIV tests. "

Pirouette
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Date Joined Mar 2014
Total Posts : 5739
   Posted 9/22/2017 4:49 PM (GMT -6)   
Excellent - thank you for sharing mpost. I will add this to my "testsarecrap" list.

-p
Lyme Moderator
Chronic late-stage lyme—likely infected in '00; Clinically dx Mar'14 w/ Babs, Fry Labs+ Bart-like, CDC+ Bb. First treated 4-5 viruses & GI/immune. Herbal antimicrobials in May; IV port-started Rocephin in Nov; added vancomycin Mar'16;
DETOX: Pinella/Burbur/Parsley/Milk thistle/Burdock/Red root; Samento/Banderol/Enula; JK/Turmeric; BFM-1; antifung; many many supps; cholestyramine!

Girlie
Forum Moderator


Date Joined May 2014
Total Posts : 26270
   Posted 9/22/2017 4:52 PM (GMT -6)   
Along the lines of P's thinking - Was this found on "testsarecrap.com" ?? tongue


My Dr. had me do the two tiered test- never got to the WB because the IFA was negative.
What a joke!
Moderator, Lyme Forum
Symp started April/2013; Buhner's Lyme May 15-July24/14; Igenex pos. July 3/14
Doxy: July 4-Aug.24/14;Zithro July26-Aug24/14; Amox + Proben. Aug. 29/14;
added biaxin Sept. 26/14
Disc. amox,added Ceftin Nov. 20th.;
Disc. biaxin added Buhner bart herbs Dec/14;Jan/15 pulsing Tinda (w/ Ceftin);
Abx/herb break Apr-July/15; July-mino; Aug. added Rif;
Nov./15 mino - to biaxi

Pirouette
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Date Joined Mar 2014
Total Posts : 5739
   Posted 9/22/2017 5:33 PM (GMT -6)   
G -

Yes - something like that!

Luckily, my LLMD knew to ignore the negative ELISA and she gave me the IGeneX anyway. We provoked w/ OLE for a month before the WB, too. The CDC-positive WB was essential for my insurance coverage (they are now suing my LLMD so no one else will benefit from the same coverage I had...criminals). But it has also come in handy when other a**hat MDs challenge that I don't have Lyme. I started bringing the test with me to all my other MD appts --- until I found Lyme-knowledgeable MDs. They smart. Don't ask the stupid questions.

-p
Lyme Moderator
Chronic late-stage lyme—likely infected in '00; Clinically dx Mar'14 w/ Babs, Fry Labs+ Bart-like, CDC+ Bb. First treated 4-5 viruses & GI/immune. Herbal antimicrobials in May; IV port-started Rocephin in Nov; added vancomycin Mar'16;
DETOX: Pinella/Burbur/Parsley/Milk thistle/Burdock/Red root; Samento/Banderol/Enula; JK/Turmeric; BFM-1; antifung; many many supps; cholestyramine!

Lapis_29
Regular Member


Date Joined Sep 2017
Total Posts : 189
   Posted 9/22/2017 5:45 PM (GMT -6)   
what? nah, couldn;t be!

we are all just nuts didn't ya know?

Doctors know everything!

Girlie
Forum Moderator


Date Joined May 2014
Total Posts : 26270
   Posted 9/22/2017 6:12 PM (GMT -6)   
My Dr. (non-LL) did accept the positive Igenex WB test though...so she got brownie points for that.


(I don't think she had any control with the government testing stopping at the IFA and not proceding with the WB)
Moderator, Lyme Forum
Symp started April/2013; Buhner's Lyme May 15-July24/14; Igenex pos. July 3/14
Doxy: July 4-Aug.24/14;Zithro July26-Aug24/14; Amox + Proben. Aug. 29/14;
added biaxin Sept. 26/14
Disc. amox,added Ceftin Nov. 20th.;
Disc. biaxin added Buhner bart herbs Dec/14;Jan/15 pulsing Tinda (w/ Ceftin);
Abx/herb break Apr-July/15; July-mino; Aug. added Rif;
Nov./15 mino - to biaxi

Post Edited (Girlie) : 9/22/2017 6:49:22 PM (GMT-6)


PDXtransplant
Regular Member


Date Joined Jun 2017
Total Posts : 70
   Posted 9/24/2017 10:15 PM (GMT -6)   
How long is considered 'early stage' as mentioned in the abstract?

mpost
Veteran Member


Date Joined Feb 2015
Total Posts : 1064
   Posted 9/24/2017 11:35 PM (GMT -6)   
PDXtransplant said...
How long is considered 'early stage' as mentioned in the abstract?


i think the conclusion is you should not use standard two-tier lyme tests, you dont expect the test to go from 74.9% false positive for early stage to 0.1% if you stay one more day after 21 days, do you?

go to a specialized lab.

Psilociraptor
Veteran Member


Date Joined Jul 2016
Total Posts : 993
   Posted 9/25/2017 5:35 AM (GMT -6)   
"you dont expect the test to go from 74.9% false negative for early stage to 0.1% if you stay one more day after 21 days"

Actually it's right there in the abstract. The late stage rate is 16.7%. Not quite 0.1%, but it's important to note the difference between early and late stage because of the time it takes for the body to generate antibodies. In fact it's stated right on the tests itself some times that early tests may be false negative. I don't think anyone debates that. The 16.7% is what's really important as well as the fact that sensitivity goes down with arthralgia/neuropathy. I thought that was pretty interest. Overall good find mpost. Wish I was better with math

mpost
Veteran Member


Date Joined Feb 2015
Total Posts : 1064
   Posted 9/25/2017 8:21 AM (GMT -6)   
just wanted to add that this paper was written by researchers from the Imperial College London, UK...
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