Wow.......Thank goodness I am not the only one, yes I am having the same breathing problems....I thought it could be due to allergies, but not sure. It can be scary. I have been on topomax for about 2 months now I am up too 100mg a day for migraines, and it is working great!....but the breathing problems have been really scary for me. It almost seems like an anxiety attack coming on or something. I sure hope it goes away after I am use to this medication. I have another doc. appoinment Friday, I will ask the doctor. Good luck!