I take them together and find that if I take too many triptans that I experience Serotonin Syndrome. It makes me feel sicker than I already feel. I don't usually realize it until I have had a migraine for a week or so as well as symptoms like vertigo, nausea, muscle spasms and other strange symptoms that are worse than normal or don't usually accompany my migraines. Because it creeps on so slightly I only take 2 triptans in a row and then don't take any for a week. That way I know the extra serontonin is out of my system.
The person I gained the most information about this was my pharmacist. I was feeling just terrible and was taking a lot of Amerge (triptan). She covered the symptoms of Serotonin Syndrome which matched the symptoms I was experiencing.
I find if my neurologist or family doctor can't give me an accurate idea about side effects the pharmacist can usually provide better information.
I hope this helps.
Both triptans and SSRIs (anti depressants) affect the serontonin level in your brain. I believe triptans are agonists and and anti depressants are reuptake inhibitors. Agonists activate the serotonin neurons and reuptake inhibitors block the serontonin from being reuptaked (2nd half of the reaction leaving more serotonin in your brain to be used). This means that one medication creates more serotonin and another blocks it from being used up, leaving more in your system.
HEY HOPEFUL MIGRAINER.
I SAW THAT YOU TAKE TOPOMAX. BE VERY CAREFUL WHEN TAKING THIS MEDICATION.I WAS ON TOPOMAX FOR ONE YEAR, AND EXPERIENCED VERY LITTLE SIDE EFFECTS,UNTIL A TRIP TO THE ER. I HAD KIDNEY STONES. TOPOMAX CAN CAUSE LOW CITRATE LEVELS IN YOUR KIDNEYS WHICH IN TURN CAUSE KIDNEY STONES. WHEN TAKING THIS MEDICATION YOU SHOULD BE MONITORED. MY DOCOTOR HAD NO IDEA THA IT COULD CAUSE KIDNEY STONES AND I ONLY FOUND OUT BY CHANCE. I WAS READING A MAGAZINE AND IT HAD A TOPOMAX AD. GOOD LUCK TO YOU.
May I kindly remind you that typing in all CAPITALS on the internet comes across as shouting. Would you please type in upper and lower case or all lower case? I find it difficult to read your messages typed all in CAPITALS.
Post Edited (Nicky (coquitlam55)) : 11/25/2006 5:18:31 PM (GMT-7)