triptans and anti-depressants

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hopefulmigrainer
Veteran Member


Date Joined Oct 2006
Total Posts : 902
   Posted 11/14/2006 1:03 PM (GMT -6)   
Hi everyone, I'm feeling a little scared and anxious now as I have read a post about combining these drugs.  I did a google search and it warns that this combo can be fatal.  I am suffering with depression (recovering from MAJOR depression) and I get chronic migraine, can't take the preventatives and narcotics don't work for my migraines.  Is anybody else out there taking a combo like this?  I also read that "serotonin syndrome" is when SSRI and other anit-d's are used together.  I don't have the symptoms but I don't like to think what I could be doing to my body.  On the other hand, depression can kill too.  Please help if you can.
Talk2Kel 
DX: chronic migraine, cervical degeneration, depression/anxiety 
RX: Wellbutrin, Lexapro, Soma, Immitrex 
"You don't find out that God is all you've got until God is all you've got."


mommyto3
Regular Member


Date Joined Nov 2006
Total Posts : 94
   Posted 11/14/2006 1:49 PM (GMT -6)   
Please hopefulmigrainer I didn't want to scare you, and I debated on posting, but I felt once the thread was started and I knew the information that I needed to post what I knew. Please as I said in my post talk to your doctor about it, I do know some people who combine them. In the warning it talks about this and says that it can be done and you and your doctor just need to know and be aware and on top of it. Please I'm sorry I don't want to scare or worry you---we are all suffering enough as it is with our medical issues and don't need to worry more about side effects of our medications, I just felt like it needed to be posted once the thread was started....I'm sorry if I contributed anymore to your worry, my intentions were only good, not to scare anyone...

hopefulmigrainer
Veteran Member


Date Joined Oct 2006
Total Posts : 902
   Posted 11/14/2006 2:10 PM (GMT -6)   
Oh, don't worry. I don't really have a lot of faith in doctors. My docs just push pills and tell me "not to worry" about side effects. I am presently being tested for Glaucoma and both the drugs "Topamax" and "Pamelor" have this as a side effect but ALL of my docs say "na!" That bothers me! Thanks for your post. It's better to be in the know.
Talk2Kel 
DX: chronic migraine, cervical degeneration, depression/anxiety 
RX: Wellbutrin, Lexapro, Soma, Immitrex 
"You don't find out that God is all you've got until God is all you've got."


Nicky (coquitlam55)
Veteran Member


Date Joined Jul 2005
Total Posts : 505
   Posted 11/14/2006 4:49 PM (GMT -6)   

Hi hopefulmigraineur,

I take them together and find that if I take too many triptans that I experience Serotonin Syndrome. It makes me feel sicker than I already feel. I don't usually realize it until I have had a migraine for a week or so as well as symptoms like vertigo, nausea, muscle spasms and other strange symptoms that are worse than normal or don't usually accompany my migraines. Because it creeps on so slightly I only take 2 triptans in a row and then don't take any for a week. That way I know the extra serontonin is out of my system.

The person I gained the most information about this was my pharmacist. I was feeling just terrible and was taking a lot of Amerge (triptan). She covered the symptoms of Serotonin Syndrome which matched the symptoms I was experiencing.

I find if my neurologist or family doctor can't give me an accurate idea about side effects the pharmacist can usually provide better information.

I hope this helps.


Nicky
Co-moderator Migraine Forum
 
I'm working everyday to overcome the pain and depression that comes from my chronic resistant migraines.
 
 


hopefulmigrainer
Veteran Member


Date Joined Oct 2006
Total Posts : 902
   Posted 11/14/2006 4:56 PM (GMT -6)   
Hi Nicky -- does this mean that triptans contain serotonin too?
Talk2Kel 
DX: chronic migraine, cervical degeneration, depression/anxiety 
RX: Wellbutrin, Lexapro, Soma, Immitrex 
"You don't find out that God is all you've got until God is all you've got."


Nicky (coquitlam55)
Veteran Member


Date Joined Jul 2005
Total Posts : 505
   Posted 11/14/2006 7:18 PM (GMT -6)   

Hi,

Both triptans and SSRIs (anti depressants) affect the serontonin level in your brain. I believe triptans are agonists and and anti depressants are reuptake inhibitors. Agonists activate the serotonin neurons and reuptake inhibitors block the serontonin from being reuptaked (2nd half of the reaction leaving more serotonin in your brain to be used). This means that one medication creates more serotonin and another blocks it from being used up, leaving more in your system.

Does this make sense?

Nicky
Co-moderator Migraine Forum
 
I'm working everyday to overcome the pain and depression that comes from my chronic resistant migraines.
 
 


hopefulmigrainer
Veteran Member


Date Joined Oct 2006
Total Posts : 902
   Posted 11/14/2006 8:49 PM (GMT -6)   
Hi Nicky - thanks. I think I get it. :) I will discuss this matter further with my neuro and the pharmacist.
Talk2Kel 
DX: chronic migraine, cervical degeneration, depression/anxiety 
RX: Wellbutrin, Lexapro, Soma, Immitrex 
"You don't find out that God is all you've got until God is all you've got."


hopefulmigrainer
Veteran Member


Date Joined Oct 2006
Total Posts : 902
   Posted 11/21/2006 7:39 PM (GMT -6)   
Just and FYI -- I went to the pdoc today and she told me (before I could bring it up) that I needed to stop Lexapro because an article was published for psychiatrists about triptans and SSRIs. I'm surprised that the neuro didn't catch this. Anyway, now I'm just taking Wellbutrin which is Dopamine and neophenefrine.
"You don't find out that God is all you've got until God is all you've got."
 
"The mighty oak tree was once a little nut that held its ground."
 
"You are richer today if you have laughed, given or forgiven."


Nicky (coquitlam55)
Veteran Member


Date Joined Jul 2005
Total Posts : 505
   Posted 11/24/2006 3:26 AM (GMT -6)   
Hello,
 
That's good I think as long as the new anti depressant works. I tried switching and couldn't find one that works. I use triptans rarely so I'm just really carefull with them. I don't take more than 2 in a week. Now that my migraines are better under control that's feasible.
 
Good luck with the new med. :-)
Nicky
Co-moderator Migraine Forum
 
I'm working everyday to overcome the pain and depression that comes from my chronic resistant migraines.
 
 


hopefulmigrainer
Veteran Member


Date Joined Oct 2006
Total Posts : 902
   Posted 11/24/2006 1:58 PM (GMT -6)   
Thanks Nicky.  I take triptans frequently.  The only narcotic that I have ever tried is Vicodin and it never touched my migraine pain.  That's how I know they are migraine - triptans are the only thing that work (when they work).  My psyche had me taking both Wellbutrin and Lexapro.  Now, I will only be taking Wellbutrin.  I feel okay knowing that at least I've already been taking the Wellbutrin but I definitely cannot afford a relapse in my depression.  Many life changes going on now and only a month ago I was in a bad way.  Thanks for your reply.

"You don't find out that God is all you've got until God is all you've got."
 
"The mighty oak tree was once a little nut that held its ground."
 
"You are richer today if you have laughed, given or forgiven."


BREA
New Member


Date Joined Nov 2006
Total Posts : 7
   Posted 11/24/2006 5:25 PM (GMT -6)   

HEY HOPEFUL MIGRAINER.

I SAW THAT YOU TAKE TOPOMAX.  BE VERY CAREFUL WHEN TAKING THIS MEDICATION.I WAS ON TOPOMAX FOR ONE YEAR, AND EXPERIENCED VERY LITTLE SIDE EFFECTS,UNTIL A TRIP TO THE ER.  I HAD KIDNEY STONES. TOPOMAX CAN CAUSE LOW CITRATE LEVELS IN YOUR KIDNEYS WHICH IN TURN CAUSE KIDNEY STONES.  WHEN TAKING THIS MEDICATION YOU SHOULD BE MONITORED. MY DOCOTOR HAD NO IDEA THA IT COULD CAUSE KIDNEY STONES AND I ONLY FOUND OUT BY CHANCE.  I WAS READING A MAGAZINE AND IT HAD A TOPOMAX AD.  GOOD LUCK TO YOU.


hopefulmigrainer
Veteran Member


Date Joined Oct 2006
Total Posts : 902
   Posted 11/24/2006 5:36 PM (GMT -6)   
That's terrible.  I hope that you are okay now.  I don't take Topomax.  I tried it twice.  The second time I tried it reluctantly but went off of it in 1 week.  I have recently been diagnosed "glaucoma suspect."  Topamax can also cause glaucoma.  As far as I'm concerned, it is just far too powerful of a drug. 
"You don't find out that God is all you've got until God is all you've got."
 
"The mighty oak tree was once a little nut that held its ground."
 
"You are richer today if you have laughed, given or forgiven."


Nicky (coquitlam55)
Veteran Member


Date Joined Jul 2005
Total Posts : 505
   Posted 11/25/2006 6:15 PM (GMT -6)   

Hi Brea,

May I kindly remind you that typing in all CAPITALS on the internet comes across as shouting. Would you please type in upper and lower case or all lower case? I find it difficult to read your messages typed all in CAPITALS.

Thank-you,



Nicky
Co-moderator Migraine Forum
 
I'm working everyday to overcome the pain and depression that comes from my chronic resistant migraines.
 
 

Post Edited (Nicky (coquitlam55)) : 11/25/2006 5:18:31 PM (GMT-7)


perception
New Member


Date Joined Jan 2012
Total Posts : 15
   Posted 1/27/2012 5:44 PM (GMT -6)   
dear migraines with nerve pain, I can so relate. I just want to let you know that topamax never really did decrease frequency except perhaps when I had medication induced issues. I think that this neuroepileptic should be used with caution as I have had significant lessening of nerve neck and shoulder pain since titrating off this med. Maybe just a remission but I think perhaps this as neurontin and especially lyrica have no real benefit for myself. In fact lyrica increased frequency and intensity. Depends perhaps on chemistry of your migraines. As for shouting can't one just read from context. I find that the message was non-treathening and perhaps indulge those with typing issues. I hope that I haven't offended anyone when doing this in other situations but find that anyone taking offence is slightly dictatorial. I think considering the greater issue of pain one should be more tolerant of us poor typists.
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