"Be yourself. An original is always worth more than a copy."
I am on Betaseron and it too has warnings about flu like symptoms. The only problem I had was getting a bit hot about 30 mins after my shot, then it would go away. I will count my blessings that I don't have it worse. One thing I wonder about is did you start out on a full injection? I know w/ my Betaseron, the doctor started me out on .25 and then gradually moved up. I think that is why I adjusted so well. Good luck with your meds!
You are a crack up. Ok everyone no backing The Cat into a corner. Hehe.
Ok this is my take on what I know about the ABC drugs. I am by NO means an expert. My neuro gave me a choice when I was offered my drugs. She said she would do any of the drugs but that she was most experienced with Rebif and Copaxone. It is my understanding that Avonex and Rebif are extremely similar. They are both "beta interferon 1-a". The difference between those two is the Avonex is injected once a week into the muscle. It has the LONG needle that some are a bit frightened of. Rebif is a very similar drug but it is injected three times a week sub-q. Betaseron is a slightly different mix of that beta interferon. It is called beta interferon 1-b. It is also injected 3 times a week sub-Q. All of the interferons work by lowering the bodies gamma interferon that is supposidly part of the MS disease mechanism. It attempts to block the T-cells from attacking the myelin. For some reason this creates an anti-inflammatory situation as well. One if the draw backs of intereferon is that over time (several years) some people build anitbodies against the drug and they must switch to a different drug to keep the affectiveness going.
Copaxone works differently. Copaxone is injected daily sup-q. Although doctors don't really understand how any of these drugs really work on a cellular basis, they are sort of guessing. They think that copaxone works by flooding the body with peptide strings that are very similar to myelin and that what you get is a decoy situation. Your t-cells are so busy attacking the copaxone that your CNS is left alone (for the most part). There is not an anti-inflammatory effect with copaxone but you don't get the build up of anti-bodies with copaxone. If copaxone is working for you it probably will for the long run. Also, copaxone is supposed to be the only one of the ABC drugs that is effective against the general brain atrophy that accompanies MS.
I hope that I have given you an unbiased look. I don't mean to advertise one over the others. My understanding is the no one understands any of this real well. What may work for one person may not be right for another. It seems that the literature says to get on a therapy as soon as possible and to stay on it as long as you can. None of these drugs is a true treatment. MS will continue to progress in even the best case. We have to just hope that in the near future more effective treatments become available to us.
I know nothing about Tysbri other than it is once a month IV infusion from a hopital or clinic. I have heard great anecdotals but I have not personally read anything about it.
I hope this helped someone. It seems long and boring to me.
Love and prayers,
Post Edited (Gretchen1) : 2/10/2008 8:54:49 AM (GMT-7)
Thanks everyone for the words of encouragement!! I will hang in there and hopefully this next dose won't be so bad.