I have been on Rebif since June and the first few months I had the flu like symptoms for a few weeks, i take my injection at night time maybe an hour or so before bed along with 2 painkillers (mild ones) that way I am sleeping most of the symptoms off. I was only dx with MS March time 2008, before I went on Rebif I had 2 relapses within 8 weeks, one a disabling one, constant numbness in my hands and constant fatigue.
since being on Rebif I have no numbness (although when i am sleepy it starts in my left hand) and I seem to be OK on it, everyone is different but so far it has helped control my symptoms, and taen the injection before bed along with the painkillers was my MS nurses idea and it worked. I get my blood checked every 3 mths to ensure liver is ok.
hope you get the right meds for you.