I have MS and Lupus. DX'd with MS in 1994, however symptoms subsided and it has been in remission since. Started feeling awful after my son was born in 2000...feeling exhausted and achy all the time. Plus my muscles and joints hurt quite a bit. Attributed it to the MS and ignored it. (Not smart!) Finally just a few months ago I reluctantly made an appt with the neurologist who tested me for Lupus. What I had been trying to ignore was not neurological at all. Turns out I have both. The blood tests he did were for Lupus, antiphospholipid syndrome, sjogrens, HIV, Lyme disease and a few others. The ANA came back positive along with the anti-ds dna which was sky high. Add those tests to the rash I get in the sun and mouth ulcers that have lingered for nearly a year and it was without a doubt Lupus. So the neuro did an MRI which showed 25 lesions. Then a spinal tap and there is some kind of MS marker they can find in the spinal fluid which was positive. Also, Lupus that mimicks MS apparently shows up in the spinal fluid (white cell count and protiens I think, but don't quote me) and those were normal. So the neuro and rheumy are certain I have both Lupus (SLE) and M.S. Wow, what kind of luck do I have? Well, I started Plaquenil and I feel pretty dang good so I am not complaining at all. Considering what's wrong with my immune system I'm just peachy with feeling fatigued and achy compared to the alternatives. Hope I helped! Let us know how all your testing goes.