Hang in there! You are dealing with a lot and the MS is contributing to your overall mind set. It sounds like you are very depressed (you can blame you!?)and need to address this with your physician. Is your wife helping you with the children at all or just looking for a place for herself? You need to find something to do to relieve the stress. I was just in an infusion session with a girl that was also getting Tysabri and she called it her mirable drug. She was having trouble walking. She says in the past it takes her a week and then she has picked right back up where she was and feels great. So stay strong and take it one day at a time. It will get better! I've had MS for 18 years, since 22, and it is a rollercoaster ride.