I have been taking Rebif since January 2004 (almost 2 years). I am very fortunate in that I was able to "skip" most of the usual side effects.
I did 20% of my Rebif for 2 weeks (what an expensive waste), then 50% for another 2 weeks. I use the auto-injector (Rebiject), and for the first couple of months I always took 1 Ibuprofen and 1 Tylenol a few hours before my injection. I've always done my injection late in the evenings (around 10:00 PM) so that I could sleep through possible side effects.
I do my injections on Sunday, Tuesday, and Thursday nights so if we want to go away for the weekend I'm needle-free Friday and Saturday, and do not have to worry about it until Sunday night.
Others I know who had the side effects with Rebif said the problems lessened/ went away usually within 6 months.
Best of luck,
Post Edited (moscrapbookqueen) : 10/29/2006 3:34:31 PM (GMT-7)