Long story hopefully somewhat short . . . I tried Avonex which I mentioned before and had no strength (could not even pick up my baby for at least 2 days) and debilitating headaches for 5 days just to turn around and get stuck again.
My neurologist started giving me monthly IV Steroids while we waited to find out about Tysabri. I didn't want to lose the efficacy that the steroids had proven to have had for me.
My first Tysabri infusion was a breeze!!!!!! I loved the entire experience (well as much as one can with a needle stuck in their arm for over an hour - really no different than my IV Steroids). My infusion center was amazing from staff to comfort! I had a headache for about 3 days maybe but nothing compared to after the Avonex shots. I feel I have found the drug for me. You asked if I feel a difference? Not really but I am not in the middle of an attack right now, but I have spoken to others who were on the drug before it was pulled and said it was a wonder drug. Walking with a cane to no cane kind of difference.
As for cost? No idea. I do know that Anthem BCBS only will approve the drug infusion if a doctor is on site.
Good luck to you. I hope that you find Tysabri as easy of an experience as I did.