I’ve suffered from constipation for 15 years and believe me I’ve had my share of depression with that too. I'm a 53 yr old woman, 125 lbs, 5'7". I’ve seen enough doctors too, I’ve had all the tests, including the xrays with the markers and the defography. I’ve tried the drugs from the mild laxatives to Zelnorm to Amitiza. Nothing worked. I’d go as long as 3 weeks before I would have a BM, then I'd give in and then I’d have to take 3 strong laxatives. Those 3 weeks were painful. Just awful waiting around for something to happen, feeling more and more bloated, not being able to button my pants as the weeks went by. The left side always hurt the most. Finally I’d give myself an enema and I’d have relief. This went on year after year. I was miserable and depressed. Four doctors told me I needed to have part of my colon removed due to a motility problem. Since I had been using the enema all those years, I worried that I was doing serious damage to my colon. I gave it one more try with another doctor. The 5th doctor told me if continued to use the enema every day, that it would not hurt me and that I did not need to have part of my colon removed. Well that was all I needed to hear. I went home and decided I needed to change my thinking. I had to come to terms with it and accept it and that it was going to be okay. It was going to be a routine like brushing my teeth. I could deal with it. Other people have a BM every day, well, so was I. Only I was going to do it a little differently. And it was no big deal. So now, I don’t wait until I am in pain, I just do it every day (in the morning before my shower). I get up 30 minutes earlier and I don’t think about it anymore. It’s easy. It’s actually my quiet time. I’m not depressed anymore and I finally got my life back.