Do you use a convex bag? You can develop pressure sores and may need to try an alternative for a while. I've had Pyoderma before (still have a huge scar from it!) and it was just awful. However, I knew mine was directly related to my crohn's disease. Is there any way your colitis has returned? --or you in fact have crohn's?? I know I tried packing my wound with angel hair and then covering with tegaderm, using pro-topic for a while, and also tried using Nasal-crom (oddly enough the ingredient in this nasal spray helped to dry out the wound a bit). All things helped a bit, but the only thing that made a difference was getting my crohn's under better control. Sorry, I'm not more help.