Bimix question

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Bootheel
Regular Member


Date Joined Oct 2007
Total Posts : 300
   Posted 9/5/2008 8:18 AM (GMT -6)   
I have been on Bimix for about 4 months with satisfactory results.  It took about 8 to 10 tries to perfect the technique.  I have to use at least .5cc or more to obtain an erection.  I am concerned that this may be to much.  I have limited my injections to once a week because I have noticed a slight curve developing.  I am seeing my Uro in a couple of weeks and am thinking of switching to Trimix.  I know that it requires less medication.  Has anyone switched from Bimix to Trimix with better results?  I am also concerned that there may be a little pain associated with the extra ingredient.
Age 65
Diagnosed 10/12/07
PSA 6.3
Biopsy 18 core samples, 2 positive <5%
Stage T1a Gleason 6 (3+3)
LRP  1/29/08
Post-op
Gleason 7 (3+4)
1 positive margin (.3cm)
T2C 
5/15/08- 1st Post-Op PSA 0.07 Undetectable
8/11/08 -2nd Post-OP PSA 0.02 Undetectable
8/15/08- No more pads as of today  Whoopee!!!


lifeguyd
Veteran Member


Date Joined Jul 2006
Total Posts : 573
   Posted 9/5/2008 8:43 PM (GMT -6)   

 

I am using bi-mix too.  My experience is that I need about .4 to .5 ml to be effective.  I too have noticed a curve at times.  It appears to curve more when it is hardest. 

I too wondered about adding the third ingredient, but I have already tried and rejected the 100% alprostadil (Caverject) due to etreme discomfort.  However, if I am given some assurance that the smaller amount in tri-mix works with out the pain, I will give that a try.

I hope that we both can get some other persons's opinion and experience.


PSA up to 4.7 July 2006 , bump noted during DRE
Biopsy 10/16/06
T2A, Psa 4.7
Gleason  4+4=8  right side
DaVinci Surgery  January 2007
Post op confirms gleason 4+4=8
No extension or invasion found
No continence problems
PSA 90 day -.01  , 6 month -.01 , 9 month +.02 , 1 year +.02
Using Bi-Mix or VED 
 
 
 


biker90
Veteran Member


Date Joined Nov 2006
Total Posts : 1453
   Posted 9/5/2008 9:44 PM (GMT -6)   
Well, I never used Bimix but Trimix works fine for me with no pain. I only need .03 ml after I take L-Arginine and Viagra (generic) a couple of hours before injecting...

Jim
Age 74. Diagnosed 11/03/06. PSA 7.05. Stage T2C Gleason 3+3.
RRP 12/7/06. Nerves and nodes okay.
Catheter out on 12/13/06.  Dry on 12/14/06.
Pathological stage: T2C N0 MX. Gleason 3+4.
50 mg Viagra + 1000 mg L-Arginine + .03 cc Trimix = Excellent Results
PSAs from  1/3/07 - 7/17/08 0.00. 
Next PSA test on 1/28/09
Lung cancer dxed on 5/16/08.  Surgery on 6/25/08  T1N1M0 - Stage IIA  Start chemo in September 08
"Patience is essential, attitude is everything."


StrictlyInc
Regular Member


Date Joined Dec 2006
Total Posts : 331
   Posted 9/7/2008 5:43 PM (GMT -6)   
I use .5 cc of bimix, and find it to be quite effective. but then the mix of drugs you are taking might be a factor as far as how much...

If you are having curvature, I'd recommend seeing your urologist to see if you have plaque and/or Peyronie's developing - they might put you on a regimen of meds to reduce it (see my signature, I had this early on after trying PGE-1 and trimix before I ended up with bimix).

Good luck
____________________

Prostate cancer diagnosed: May 15, 2006 (age 40)
Gleason score: pre-surgery 3+3=6; post-surgery 3+4=7
daVinci radical prostatectomy: July 25, 2006
size of tumor: approx 1.1 inches; negative margins from surgery

- number of pads/day at 3 months after surgery: 3 to 5
- number of pads/day at 4 months after surgery: 1 to 2
- number of pads/day at 6-18 months after surgery: 0 to 1

- 1st post-surgery PSA: 0 (Nov 2006); 2nd post-surgery PSA: 0 (Feb 2007); - 3rd post-surgery PSA: 0 (May 2007);
4th post-surgery PSA: 0 (June 2007); 5th post-surgery PSA: 0 (Dec 2007); 6th post-surgery PSA: 0 (June 2008)

The search for timber: took Viagra/Cialis approx. every other day, ErecAid once a day, injections. Peyronie's diagnosed 7/5/07. Now on daily Cialis, L-arginine and pentoxyfylline. Peyronies has stabilized and significantly reversed.

- PGE1 batting average: .364 (4 for 11)
- Bimix #3 batting average: .722 (13 for 18) Bimix #1 batting average (26 for 27) = .963
- Trimix batting average: .500 (1 for 2) Grand total 44 for 58 = .759

"Lost in the valley without my horses, no one can tell me what my remorse is..."


Bootheel
Regular Member


Date Joined Oct 2007
Total Posts : 300
   Posted 9/8/2008 3:03 PM (GMT -6)   
By the way StriclyInc, what regimen of drugs and/or meds did the Dr. prescribe? Might give me a little heads-up before I see him. Any advice would be greatly appreciated
Age 65
Diagnosed 10/12/07
PSA 6.3
Biopsy 18 core samples, 2 positive <5%
Stage T1a Gleason 6 (3+3)
LRP  1/29/08
Post-op
Gleason 7 (3+4)
1 positive margin (.3cm)
T2C 
5/15/08- 1st Post-Op PSA 0.07 Undetectable
8/11/08 -2nd Post-OP PSA 0.02 Undetectable
8/15/08- No more pads as of today  Whoopee!!!


usmc155
Regular Member


Date Joined Mar 2009
Total Posts : 22
   Posted 2/8/2010 3:49 PM (GMT -6)   
I use trimix. From what you said see your uro ASAP. Scarring can and does happen and the curve is a sign you may have scarring. Many years experience and do see your uro!!

tatt2man
Veteran Member


Date Joined Jan 2010
Total Posts : 2786
   Posted 2/8/2010 4:48 PM (GMT -6)   
simple question - after reading about trimix and bimix .. are you guys with the curves rotating sides with each injection? - it talked about doing that on a regular basis -
.................
Age: 54 - gay - with spouse, Steve - 59
PSA: 04/2007- 1.68 - 08/2009 - 3.46 - 10/2009 - 3.86
Confirmation of Prostate Cancer: October 16, 2009 - 6 of 12 cancerous samples , Gleason 7 (4+3)
Doctor: Dr. Mohamed Elharram -Urologist / Surgeon - Peterborough Regional Health Centre
Radical Prostatectomy Operation: November 18, 2009 , home - November 21, 2009
Post Surgery Biopsy: pT3a- gleason 7 - extraprostatic extension - perineural invasion - prostate weight - 34.1gm -
ED Prescription: Jan 8/2010 - started daily 5mg cialis
location: Peteborough, Ontario, Canada
............


Tamu
Veteran Member


Date Joined Oct 2006
Total Posts : 626
   Posted 2/9/2010 8:00 AM (GMT -6)   

I now have a penile implant but when I was using injections I also found that I needed more and more of the Bimix to get a firm enough erection and then I was having to put up with 3 to 4 hour long erections.  I switched to Trimix but I had it formulated with one fourth the amount of Alprostadil then the normal formula.  This combination dropped my dosage to 0.07 for Trimix from the 0.4 with Bimix.  It gave me a firmer erection which lasted about half the time as the one with Bimix.  I did have some aching with it but taking some Ibruprofen about 30 minutes before injecting helped a lot.  I did have to get a prescription for the reformulated Trimix. 

Tamu 


Diagnosed 7/6/06, 1 of 10 core samples, 40%,Stage T1c, Gleason 3+3
Da Vinci on 11/01/06, Catheter out on 11/13/06
56 Years Old
Post Op Path, Gleason 3+3, Approx. 5% of prostate involved
Prostate Confined, margins clear
Undetectable PSA on 12/18/06, 6/25/07, 1/8/08
No more pads as of 1/13/07
Began injections in April '07
 


NoPro
New Member


Date Joined Oct 2010
Total Posts : 16
   Posted 1/18/2011 10:35 PM (GMT -6)   
I've been using Trimix for 3 mos.  My Trimix formulation is 10:0.5:26.5 and I've been drawing up .325 per injection. It has worked well except for 2 times when I wasn't firm enough for proper performance.  I'm trying to find the lowest dose because I don't want to visit the ER.  The only problem is the stinging sensation for several hours afterwards.  At first, I was so excited about returning to action that I put up with the pain.  However, I'll tired of putting up with the sting and am going to switch to Bimix.  The compounding pharmacist said that they could put lidocaine in the Trimix to cut down on the pain but I figured that's pushing it with irritation from both PG and the lidocaine.
  
I called my physician today and he wrote me an Rx for Bimix #1.  I'm anxious to give it a try.  Has anyone gone through this switch and what was your experience?  I'll probably start out with .4 dosage and adjust from there.  After reviewing comments on this forum, it seems like the Trimix and Bimix dosages are close.
 
I'm keeping my fingers crossed and am thankful for an understanding wife.
 
 
Age 65

Diagnosed April 2010
4 sites involved; Gleason scores: 7 & 8
open radical prostatectomy June 2010
Lymphs & margins not involved

James C.
Veteran Member


Date Joined Aug 2007
Total Posts : 4438
   Posted 1/19/2011 11:10 AM (GMT -6)   
NoPro, thanks for joining us. I think the Bimix should work well for you, once you dial in the amount. One question: are you familiar with our plump and prick method so many of us use here? That's the using a pump or you hand to milk blood into the penis, partially inflating it with blood, using a ring to hold the blood in and then injecting? This allows for maximum adsorbancy time. If not, we got a detailed version to learn how. Really makes a difference in the amount of drug used and the success rate.
James C. Age 63
Gonna Make Myself A Better Man tinyurl.com/28e8qcg
4/07: PSA 7.6, 7/07 Biopsy: 3 of 16 PCa, 5% involved, left lobe, GS6
9/07: Nerve Sparing open RP, Path: pT2c, 110 gms., clear except:
Probable microscopic involvement-left apical margin -GS6
3 Years: PSA's .04 each test until 04/10-.06, 09/10-.09, 01/11-.09
ED-total-Bimix 30cc

NoPro
New Member


Date Joined Oct 2010
Total Posts : 16
   Posted 1/19/2011 9:07 PM (GMT -6)   

James C.

Thanks for your response.  I would like to review the plump and prick technique.  Where do you find the information?  I have been stimulating the penis prior to injection and holding the base after while using the other hand to work the Trimix into both sides.  The ring sounds like a great idea.  Where do you purchase them? 

 I'm going to fill my Bimix Rx tomorrow and hope for good results without the after injection pain.

 


Age 65

Diagnosed April 2010
4 sites involved; Gleason scores: 7 & 8
open radical prostatectomy June 2010
Lymphs & margins not involved

Cajun Jeff
Veteran Member


Date Joined Mar 2009
Total Posts : 3553
   Posted 1/19/2011 9:29 PM (GMT -6)   
NoPro, Good luck with the BiMix.. I think you will find the ring will help. Do let us know if it works better for you.

Cajun Jeff
9/08 PSA 5.4 referred to Urologist
9/08 Biopsy: GS 3+4=7 1 positive core in 12 1% cancer core
10/08 Nerve-Sparing open radicalSurgery Path Report Downgrade 3+3=6 GS Stage pT2c margins clea
r3 month: PSA <0.1
19th month: PSA <0.1
2 year PSA <0.1
Only issue at this time is ED but getting better

James C.
Veteran Member


Date Joined Aug 2007
Total Posts : 4438
   Posted 1/20/2011 9:02 AM (GMT -6)   
NoPro, read this thread to learn probably a lot more than you every wanted to know about it......, tongue

www.healingwell.com/community/default.aspx?f=35&m=1827385
James C. Age 63
Gonna Make Myself A Better Man tinyurl.com/28e8qcg
4/07: PSA 7.6, 7/07 Biopsy: 3 of 16 PCa, 5% involved, left lobe, GS6
9/07: Nerve Sparing open RP, Path: pT2c, 110 gms., clear except:
Probable microscopic involvement-left apical margin -GS6
3 Years: PSA's .04 each test until 04/10-.06, 09/10-.09, 01/11-.09
ED-total-Bimix 30cc

NoPro
New Member


Date Joined Oct 2010
Total Posts : 16
   Posted 1/20/2011 10:30 AM (GMT -6)   
To James C.
 
I went online to find a penis ring and received more info. that I could process.  What kind do you use and where did you get it?
 
Thanks
Age 65

Diagnosed April 2010
4 sites involved; Gleason scores: 7 & 8
open radical prostatectomy June 2010
Lymphs & margins not involved

MrGimpy
Veteran Member


Date Joined Jul 2009
Total Posts : 504
   Posted 1/20/2011 10:44 AM (GMT -6)   
NoPro,

Many here use the Osbon Erecaide Vacuum pump which comes with assorted rings. It is covered ( check with your Ins to see how much coverage) and required an Rx. It is a very high quality unit

some also just go into their local adult shops and pick an alternative pump, rings should come with them

Here is the Osbon Info

www.timmmedical.com/patients/

or look here for just the rings, not sure how you will get them on without the use of a pump though

www.erecaidpumps.com/erecaidbands.htm

James C.
Veteran Member


Date Joined Aug 2007
Total Posts : 4438
   Posted 1/20/2011 11:03 AM (GMT -6)   
NoPro, if you have a pump, any of these will work fine. Also on the page is a couple that uses an adaptor cone to apply, in case you don't need a pump to get the plumping>

www.vitalitymedical.com/tension-bands-penis-rings.html

If you need a pump then a good set of pump and rings, which I use and several others here, is this one:

www.vitalitymedical.com/encore-impo-aid-manual-vacuum-erection-device-otc.html

It works just a well and as safe as the $500 one the doctors sell.
James C. Age 63
Gonna Make Myself A Better Man tinyurl.com/28e8qcg
4/07: PSA 7.6, 7/07 Biopsy: 3 of 16 PCa, 5% involved, left lobe, GS6
9/07: Nerve Sparing open RP, Path: pT2c, 110 gms., clear except:
Probable microscopic involvement-left apical margin -GS6
3 Years: PSA's .04 each test until 04/10-.06, 09/10-.09, 01/11-.09
ED-total-Bimix 30cc

Piano
Veteran Member


Date Joined Apr 2008
Total Posts : 844
   Posted 1/20/2011 5:17 PM (GMT -6)   
Unless you need to match a specific pump, there's no need to buy expensive constriction rings . I use standard office rubber bands, doubled over. For injections I used three. For use with a cheap VED, I use five or six.
No symptoms; PSA 5.7; Gleason 4+5=9; cancer in 4/12 cores
Non-nerve-sparing RRP 7 March 2008 age 63
Organ confined, neg margins. Gleason downgrade 4+4=8
Fully continent
Bimix worked well; now using just VED
PSA undetectable at first but now 0.3, doubling time 7 months
No radiation but ADT coming unless I can slow down the rise...

lifeguyd
Veteran Member


Date Joined Jul 2006
Total Posts : 573
   Posted 1/20/2011 7:48 PM (GMT -6)   
Interesting...I see that I posted on this thread back in 2008 about using bi-mix.  I am still using bi-mix today.   I don't remember ever using the .5 to .6 I listed in 2008 ( maybe it was .05 ?).  I use.14 now and have 100% success.  I still have what is probably minor plaque buildup, but it has not changed in 3 years.  Based on that my urologist has never advised that I stop using injections.
PSA July 2006 4.7 , Nodule found
biopsy 10/06 very agressive gleason4+4=8 identified
DaVinci surgery, January 2007
Post Ob confirms, gleason 4+4=8 with no extension or invasion
no long term continence problems
post surgery PSA continues to be undetectable at 4 years
ED problems continue, using bimix
born 1941

NoPro
New Member


Date Joined Oct 2010
Total Posts : 16
   Posted 5/2/2011 9:52 AM (GMT -6)   

I switched from TriMix to BiMix due to the pain from PGE.  I'm using .4ml per dose with decent results.  The only difference is the erection with BiMix.  It is adequate for intercourse, but isn't quite as good as it was with TriMix.  The erection curves slightly downward toward the end although it is just as long.  It isn't curving to the side so I don't believe that it is a side effect.  Perhaps, not quite as much blood is entering the cavernosum without the PGE in the mix.

I'm thinking about trying TriMix again with only 1/4 of the usual PGE in the mix.  Unfortunately, I'm one of the 33% that has a severe reaction to PGE so I'm reluctant to switch.

Has anyone out there had similiar experiences to mine?


Age 65

Diagnosed April 2010
4 sites involved; Gleason scores: 7 & 8
open radical prostatectomy June 2010
Lymphs & margins not involved

North49
Regular Member


Date Joined Feb 2011
Total Posts : 83
   Posted 5/2/2011 5:31 PM (GMT -6)   
I have use the Bimix 30 papaverine/1 phentolamine and was up to .80 with pretty good results, not 100% wood but close. I am just trying out the double strength Bimix, 26 papaverine/2 phentolamine and did a test shot of .45 and the result was pretty much the same, maybe less than the .80 single dose Bimix. I'm going to up the next shot to .55 of the double strength and hope for firmer results.

I opted not to try the trimix injection since the trimix gel suppository gel gave me too much burning with minimal inflation. Next appt with the uro I'll ask him about adding the PGE1 in a lower strength to see what issues it may have.
PSA 5.6 - 04/2010 - DRE positive
PSA 6.7 - 09/2010
Biopsy - 09/2010 - Age 53
T2b/c Gleason 7, 4+3
PSA 8.2 - 12/2010
RRP - 12/2010
pT3a, Gleason 7, 3+4, 20% PCa
pNO
Negative margins and seminal vesicles
RP 37.3 g
No further treatment recommended.
PSA <0.01 - 03/2011 - 3 month post-op

NoPro
New Member


Date Joined Oct 2010
Total Posts : 16
   Posted 5/2/2011 9:01 PM (GMT -6)   

StrictlyInc,

My curvature is right at the end and it goes slightly down.  I thought that Peyronie's only causes curvature to the side.  This wasn't gradual but happened almost immediately after changing from TriMix to BiMix.  I have an appt. with my Urol. in 2 weeks and I'll get his opinion.  I do change injection sites from one side to the other everytime so I don't think that's the problem.


Age 65

Diagnosed April 2010
4 sites involved; Gleason scores: 7 & 8
open radical prostatectomy June 2010
Lymphs & margins not involved

North49
Regular Member


Date Joined Feb 2011
Total Posts : 83
   Posted 5/2/2011 10:01 PM (GMT -6)   
Although I haven't discussed this further with my uro, at my last appointment he commented that VED's can cause Peyronie's. Since I'm now on injectables I want to be sure it's not something I'm doing even though at this point I haven't noticed anything unusual.

I seem to remember reading that PGE also may contribute to Peyronie's
PSA 5.6 - 04/2010 - DRE positive
PSA 6.7 - 09/2010
Biopsy - 09/2010 - Age 53
T2b/c Gleason 7, 4+3
PSA 8.2 - 12/2010
RRP - 12/2010
pT3a, Gleason 7, 3+4, 20% PCa
pNO
Negative margins and seminal vesicles
RP 37.3 g
No further treatment recommended.
PSA <0.01 - 03/2011 - 3 month post-op

klez
New Member


Date Joined May 2011
Total Posts : 9
   Posted 5/16/2011 9:49 PM (GMT -6)   
Hi all,

I am a new member and new user of bi-mix and came across this forum. The problem is, that I am having some issues with hypertension, which seems contradictory to the usual effect of a vaso-dilator. But it usually happens in the days following an injection. I was wondering if anyone might have experienced that, or have any knowledge about it, or know where I might get more information?

Thanks.
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