Has anyone tried TriMix-gel?

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Stonesfan
New Member


Date Joined Feb 2009
Total Posts : 1
   Posted 2/4/2009 8:07 AM (GMT -6)   
      I discovered this forum about a month ago, and its been very helpful and a great source of information.  I am aprroximately 4 months beyond open RPP surgery.  The incontinence has basically resolved itself, and while I need a pad while working out, otherwise I am pad-free.  The ED is another matter.  I have had basically no response to any of the pills, notwithstanding trying all 3.
 
     I am not looking forward to the prospect of injections.  I see that TriMix Labs now has a gel product that does not require an injection and can be carried at room temperature rather than refrigerated.  Does anyone have any expereience with using this gel product?  From what I've read here, getting the right mixture/strength of the solution was somewhat tricky, and I was also wondering how that worked with the gel product.
 
     Any help would be appreciated.  Thanks.
 
 
Age:  52
Dx:    7/2008, PSA 7.1, T1c, 2/12 cores positive (25% and 8%),  
         Gleason 3+3=6
RPP:   10/2008, Johns Hopkins (open surgery)
Path:  Gleason 3+3=6; pT2; tumor extent moderate; organ confined;
         margins negative; no seminal vesicle invasion; no lymphatic 
         invasion; all lymph nodes negative 
         
  


Purgatory
Elite Member


Date Joined Oct 2008
Total Posts : 23553
   Posted 2/4/2009 8:27 AM (GMT -6)   
Stones,
I want to welcome you here on behalf of the others. Sorry you have the need to be here, but its the best on the web for answers and support. Glad you are on the other side of your surgery, and sounds like you are doing fine on the incontinence part. Your pathology reports looks encouraging. I can't answer your questions about trimix, but there are plenty here experienced with it, so I am sure they will be answering soon. Once again, welcome to our little part of the world.

David in SC
Age 56, 56 at DX, PSA 7/7 5.8, 7/8 12.3
3rd Biopsy 9/8 Positive 7 of 7 cores pos, 40-90%, Gleason 7
Open RP surgery 11/14/8, Non-nerve sparing, 4 days hospital, staples out 11/24/8, 5th cath out on 1/19/9
Post-surgery Pathlogy Report:Gleason 3+4=7, pT2c, 42 grm, tumor 20%, Contained in capsular, clear margins, clear lymph nodes 
First PSA Post Surgery   2/9/9
 
 


James C.
Veteran Member


Date Joined Aug 2007
Total Posts : 4438
   Posted 2/4/2009 9:10 AM (GMT -6)   
Welcome to the club. There's at least one guy here who uses/has used the gel. Maybe he will see your post. I don't remember who ti is, sorry. You don't say, but I maybe read in your post that maybe you think the gel is rubbed on? It is inserted with an applicator in the uretha and adsorbed from there. Still some mechanism of insertion into the body. I seem to recall the effectiveness of it was in the 35 to 40% successful response range. the injections raise the sucess rate to the 85 to 100% range. It may have improved since I read that. I can tell you that once you get over the aversion to injecting yourself, and make that first stick that it is virtually painless to inject. The needle is the same as a diabetic uses and not an issue to the vast majority of the users. Hope you stay around and share with us the story if you do go with the gel...
James C. Age 62
Co-Moderator- Prostate Cancer Forum
4/07 PSA 7.6, referred to Urologist, recheck 6.7
7/07 Biopsy: 3 of 16 PCa, 5% involved, left lobe, GS 3/3=6
9/07 Nerve sparing open RRP- Path Report: GS 3+3=6 Stg. pT2c, 110gms, margins clear
16 mts: ED- 50 mg Viagra 3X week, pump daily,Trimix .35ml 2X week continues
PSA's: .04 each 3 months

Post Edited (James C.) : 2/5/2009 9:56:36 AM (GMT-7)


Rob Smith
Regular Member


Date Joined Jan 2008
Total Posts : 23
   Posted 2/5/2009 5:32 AM (GMT -6)   

Hi James,

Since you mentioned diabetic needles in your post, I was wondering if you could tell me what size you use?  I currently use 30 gauge 1/2" needles, but to help prevent fibrosis, I was thinking of using 31 gauge 5/16".  Do you think the 5/16" is too short and won't hit the mark?

Thanks,

Rob


James C.
Veteran Member


Date Joined Aug 2007
Total Posts : 4438
   Posted 2/5/2009 10:13 AM (GMT -6)   
rob, the 5/16 needles seem to work fine for most men. I haven't heard anyone here say theirs didn't work. Graphic content begins: I can see why they wouldn't if a guy had a very thick penis. I would guess that on most men, most outer penile walls are less than 5/16 inch thick when flaccid. Get a few and try it out. I have the 30ga 1/2 inch and the 31 ga 5/16 inch and the 1/2 inch are too long for me, and cause me to overshoot the target and push all the way thru the inner wall of the cavernous cavity, resulting in missed injections unless I use my preplump tech. and am very careful. The 5/16 with my patented preplumping pump and ring technique works fine for me. Experiment and see..
James C. Age 62
Co-Moderator- Prostate Cancer Forum
4/07 PSA 7.6, referred to Urologist, recheck 6.7
7/07 Biopsy: 3 of 16 PCa, 5% involved, left lobe, GS 3/3=6
9/07 Nerve sparing open RRP- Path Report: GS 3+3=6 Stg. pT2c, 110gms, margins clear
16 mts: ED- 50 mg Viagra 3X week, pump daily,Trimix .35ml 2X week continues
PSA's: .04 each 3 months


alex1
Regular Member


Date Joined May 2008
Total Posts : 27
   Posted 2/5/2009 10:24 AM (GMT -6)   
Dear Stonesfan:

A product you might want to look into is MUSE (acronym for "medicated urethral system for erections), which uses about an inch-long applicator to place the drugs (alprostadil) just inside the uretha. My urologist recommended it as a method to use before trying injections, and it has never so far failed to work for me. Very little discomfort and no fear of needles. A little expensive, but generally covered by most insurance.
58-year old attorney, no family history of PCa
Biopsy 12/29/2007 with 1 of thirteen samples positive; estimated 5% involvement
3+3=6 Gleason
TR2C Stage
RRLP on 2/21/2008 with excellent prognosis (no evidence;margins and other tissue clear) on cancer clearance and sparing of both nerve bundles
Post-OP:Actual involvement 15%, one lobe only; PCa fully contained in prostate-no involvement with other tissues and margins clear
Catheter out on 3/2/2008; fully continent by 3/31/2008
Undetectable PSA on 3/31/2008
Working on ED: 20MG Levitra every other day; Vacuum pump almost daily; some improvement, but not there yet. Started using MUSE with some success, 11/1/2008
2d undectable PSA on 7/21/2008
3d undectable PSA on 10/30/2008


hb2006
Regular Member


Date Joined Nov 2008
Total Posts : 295
   Posted 2/5/2009 11:13 AM (GMT -6)   

I tried MUSE but it never worked for me and only gave me the burning pain from the alprostadil. Studies have shown that it is effective only about 30 to 40% of the time. However, I would try it and if it works, you are one of the lucky ones.

I have switched to the Trimix injection, which works great.  


Rob Smith
Regular Member


Date Joined Jan 2008
Total Posts : 23
   Posted 2/9/2009 8:45 AM (GMT -6)   
James, thanks for the reply.  I have another question for you if you don't mind.  Have you ever notice Caverject losing it's effectiveness? I used the 20mcg strength with great success, but the last few times it hasn't worked as well (doesn't stay in system very long...15-20 mins.)  I've recently switched to the 40mcg strength with the same results.  When I first started using Caverject back last summer, my erections would always last at least an hour, but now they just don't stay.  I even tried your pre-plump technique without success.  I was wondering if I should switch to tri-mix...in your experience, did you find the tri-mix to be more effective?

James C.
Veteran Member


Date Joined Aug 2007
Total Posts : 4438
   Posted 2/9/2009 10:22 AM (GMT -6)   
Rob, Caverject does have an effectiveness period of about 3 months optimum, 6 months normal and up to 9 months in some cases. My vial says 3 months, but I am still using some 6 mts. old. The time starts when the powder is activated or the liquid is prescribed. In order of effectiveness the higher strengths of Caverject or its generic (alprostadil) is strongest and does the best job. Example: .10cc of 40mcg , then .10cc of 20mcg, then Trimix normally is 30/1/10mcg or 30/1/20mcg, then Bimix, in order of strengths. The higher the strength and/or amount of alprostadil in the solution gives the best results for most men who need that particular drug. It is very effective in chemically activating and closing the veinous valves in the penis to keep the blood in. Those men who have a lesser problem with that can use smaller amounts of Trimix or Bimix successfully, as they regain function of the veinous valves. The side effects are greatest from it also, the fabled aching and pain. It's a trade-off- alprostadil for a good response versus the aching and pain experienced by most men. My Trimix 30/1/10mcg at .20cc is about ideal for me, trading off a little bit of aching for dependable response each time.
James C. Age 62
Co-Moderator- Prostate Cancer Forum
4/07 PSA 7.6, referred to Urologist, recheck 6.7
7/07 Biopsy: 3 of 16 PCa, 5% involved, left lobe, GS 3/3=6
9/07 Nerve sparing open RRP- Path Report: GS 3+3=6 Stg. pT2c, 110gms, margins clear
16 mts: ED- 50 mg Viagra 3X week, pump daily,Trimix .35ml 2X week continues
PSA's: .04 each 3 months


Rob Smith
Regular Member


Date Joined Jan 2008
Total Posts : 23
   Posted 2/9/2009 12:08 PM (GMT -6)   
James,
 
Thanks for the quick reply.  I guess since the 40 mcg Caverject is the strongest drug available, I'll give it another try and just chalk-up the miss as wrong technique or medicine pass it optimal state.  I keep the vials of powder refrigerated until use so I believe storage is not the problem because I was instucted to keep the 40 mcg refrigerated by my pharmacist.
Anyways, thanks again for your help,
 
Rob

res
New Member


Date Joined Jun 2010
Total Posts : 3
   Posted 11/23/2010 9:10 AM (GMT -6)   
Hi Stonesfan,

I have not used the gel, but have used the tri-mix injection for about 4 years.

After the first 4 or 5 times, there is virtually no pain using the injection.
It's VERY effective.

When I see my urologist, I'll ask him about the topical gel.

Resco

bsjoplin
Regular Member


Date Joined Feb 2010
Total Posts : 280
   Posted 11/23/2010 4:51 PM (GMT -6)   
i won't pretend to have any experience, but it's not "topical" in that you rub it on...according to the website, it's squirted into the end of the urethra.
bob
Age@dx:55
5/05 PSA:1.8
12/07 PSA:3.7
7/08 PSA:4.7
8/08 Biopsy#1:3 of 6 irreg
11/08 PSA:6.5
12/08 Biopsy#2:of 12,3 cancer,other 9 irreg;Gl:3+3=6
1/22/09 RRP
1/25/09 Released
1/28/09 Path: PCa on 10%, lymph & SV benign, Gl:3+4=7,stage T2c
2/13/09 PSA:0.1
6/09 PSA:0.1
10/09 PSA:0.1
2/10 PSA:0.3
4/10 PSA:0.4 Referred to RO
5/4/10 First RT
6/25/10 Final RT;ended up 36 treatments,64.8 Gy.
8/10 PSA:0.2
11/10 PSA: 0.1

JStars
Regular Member


Date Joined Oct 2005
Total Posts : 433
   Posted 11/23/2010 10:00 PM (GMT -6)   
I have experience with Trimix Gel .. but since Stones seems lonnnnnng gone 1.5 years (how do these old posts keep popping up anyways?) with only one post, well, if he ever comes back I would advise:

"DO A SEARCH OF THE SITE".

Way back then there was probably not much about it, but now there is.

Have at it!

J

James C.
Veteran Member


Date Joined Aug 2007
Total Posts : 4438
   Posted 11/24/2010 10:03 AM (GMT -6)   
Old threads get dragged back to the top by someone posting to it at a much later time. Usually this is done by new folks who are reading through the history and will comment on something, or use one subject as an opening for their first post. Sometimes, like this, some good info will be exposed, other times, it can bring back to life other kinds, ones that probably should have been left to their well deserved slowly fading away.
James C. Age 63
Gonna Make Myself A Better Man tinyurl.com/28e8qcg
4/07: PSA 7.6, 7/07 Biopsy: 3 of 16 PCa, 5% involved, left lobe, GS6
9/07: Nerve Sparing open RRP, Path: pT2c, 110 gms., all clear except:
Probable microscopic involvement of the left apical margin -GS6
3 Years: PSA's .04 each test until 04/10-.06, 09/10-.09- Uh-Oh
ED continues: Bimix .30cc & Trimix .15cc PRN

brazilian_new_member
New Member


Date Joined Jul 2011
Total Posts : 2
   Posted 7/18/2011 2:07 PM (GMT -6)   
Dear Friends,
 
I am suffering of ED for a long period now and the available medication in the Brazilian market is not working for me (we only have the pills here).
 
I read about the trimix gel on this forum and was wondering if you know how could I get this medication here. Apparently it is only available in US.
 
If anyone could help me!
 
Many thanks in advance and kind regards.
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