trimix injections

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kreplerfp
Regular Member


Date Joined Oct 2008
Total Posts : 56
   Posted 3/12/2009 4:28 PM (GMT -6)   
 
I have ordered trimix from the pharmacy to start taking my first injections. My Doc says to start with .1 ml and see how that goes. I am in Canada and paid $122.00 for 5 mils worth. Can you buy the trimix any less expensive through ADC or any other spot. Also is .1 mil. the right amount to start with?
 
Fred
Diagnosed Feb 08
 
PSA 6.3
gleason 3+3
T2C
first biopsy 1 of 10 needles positive
surgery Sept 18 08
bone scan negative
evidence of sinus histiocytosis?
involvement of the margins identified at right and left apex and right anterior surface
also perineural invasion
no extraprostatic extention
no seminal vesicle invasion
tumor cells aggressive features of moderate to severe pleomorphism
1st PSA nov 08 undectable
kept left side bundle of nerves but lost some of the right side bundle
also had laser surgery in July 2008 to save eye sight from glaucoma hospitalized twice for kidney stones  in summer of 2008


sandstorm
Regular Member


Date Joined Dec 2008
Total Posts : 194
   Posted 3/12/2009 5:02 PM (GMT -6)   
kreplerfp

The trimix compound will come to you in an insulated container and surounded by ice packs. It must be kept refrigerated or it will deteriorate. All Day chemist would not be able to get it to you in the proper condition due to the time and distance involved.

Trimix must be made by a compounding pharmacy that can get the product to you within 24 hours so it can be kept cold.

I had such a bad reaction to my first injection of Alprostadil at .2 ml that we decided to start the first trimix injection at .05 ml. It produced about a 60% erection. I have now worked up to .08 ml and the erection is about 90% and very usable but it is lasting for 3 hours and not very comfortable for me to say the least.
 
Also I dumped the 25 guage needles prescribed to me at first and bought the 31 guage. It sure did make a difference in the injection pain factor. 
 
Hope this helps you some.


Age at DX 57
5-18-07 PSA 7.7
5-06-08 PSA 4.6  8% free psa, but stable
10-23-08 PSA 5.65 4% free psa
11-04-08 biopsy
11-11-08 2 of 12 cores positive
Gleason 3+3  6  stage t1c / post-op 3+4  7  stage t2c
CT and Bone scan negative
Da Vinci RRP 01-09-09
Catheter removed 1-15-09
Pathology Report says it's gone!
First Post-op PSA 2-17-09   0.00

Post Edited (sandstorm) : 3/12/2009 4:06:15 PM (GMT-6)


kreplerfp
Regular Member


Date Joined Oct 2008
Total Posts : 56
   Posted 3/12/2009 5:08 PM (GMT -6)   

 

Thankyou for your responce. I am a little apprehensive about using the needle and getting the injection in the right spot. My doc. didn`t give me a very good explanation about where to inject the needle. Is there a good website to demonstate where to inject?

Fred


Diagnosed Feb 08
 
PSA 6.3
gleason 3+3
T2C
first biopsy 1 of 10 needles positive
surgery Sept 18 08
bone scan negative
evidence of sinus histiocytosis?
involvement of the margins identified at right and left apex and right anterior surface
also perineural invasion
no extraprostatic extention
no seminal vesicle invasion
tumor cells aggressive features of moderate to severe pleomorphism
1st PSA nov 08 undectable
kept left side bundle of nerves but lost some of the right side bundle
also had laser surgery in July 2008 to save eye sight from glaucoma hospitalized twice for kidney stones  in summer of 2008


sandstorm
Regular Member


Date Joined Dec 2008
Total Posts : 194
   Posted 3/12/2009 5:17 PM (GMT -6)   
This is an excelent site that came from one of our moderators not to long ago. It even has diagrams that should be very helpful.

www.phoenix5.org/sexaids/injections/injectionpers.html

edited to make link clickable...lol

Post Edited By Moderator (James C.) : 3/12/2009 5:53:10 PM (GMT-6)


James C.
Veteran Member


Date Joined Aug 2007
Total Posts : 4449
   Posted 3/12/2009 6:55 PM (GMT -6)   
Here's a link to the thread listing compounding pharmacies that members here use or have used. You price for Trimix is a little high, as my last order from Franck's was $93, refrigerated shipping included. But if it's local and easy to obtain, the price difference may not mean much to you.. turn

www.healingwell.com/community/default.aspx?f=35&m=1017774
James C. Age 62
Co-Moderator- Prostate Cancer Forum
4/07 PSA 7.6, referred to Urologist, recheck 6.7
7/07 Biopsy: 3 of 16 PCa, 5% involved, left lobe, GS 3/3=6
9/07 Nerve sparing open RRP- Path Report: GS 3+3=6 Stg. pT2c, 110gms, margins clear
16 mts: ED- 50 mg Viagra 3X week, pump daily,Trimix .35ml 2X week continues
PSA's: .04 each 3 months


biker90
Veteran Member


Date Joined Nov 2006
Total Posts : 1455
   Posted 3/12/2009 10:23 PM (GMT -6)   
I have used Trimix for a nearly two years with great results using only .04 cc in a .5 cc diabetic syringe with a 5/16 inch 31 gauge needle. I take 50 mg Viagra (substitute) about and hour before the injection then use a little manual stimulation to get things started then inject. There is no pain or ache and the erection lasts for a couple of hours.

Of course all of us are different and in different stages of ED recovery so my formula might not work for you. I think it is important that we share our experience with all the ED meds.

My 5 ml bottle of Trimix has been badly abused. Using so little it lasts a long time past the expiration date and is still potent. Also I have left it out for a week at a time in 75 degrees and its still good. Refrigeration lowers the possibility of contamination but leaving it out doesn't reduce the effect.

Being 75 years old (soon) I probably will never regain a natural, unaided erection. I was using Levitra for years before I got cancer so its not surprising that I have an ED problem now. This is all fine with me because my undetectable PSAs for the last 2 1/2 years assure me that the cancer is gone. Also my wife and I have the best sex of our 54 years of marriage. The dry, multiple orgasms are great and now we have sex until we get tired instead of until I get finished.

I apologize if this post has TMI but its important to show those folks just coming on board that PCa treatment is not the end of the world, in fact it can make our sex life better...

Jim
Age 74. Diagnosed 11/03/06. PSA 7.05. Stage T2C Gleason 3+3.
RRP 12/7/06. Nerves and nodes okay.
Catheter out on 12/13/06. Dry on 12/14/06.
Pathological stage: T2C N0 MX. Gleason 3+4.
50 mg Viagra + .04 cc Trimix = Excellent Results
PSAs from 1/3/07 - 7/17/08 0.00.
PSA on 1/28/09 - 0.02
Lung cancer dxed on 5/16/08. Surgery on 6/25/08 T1N1M0 - Stage IIA Finished 4 cycles of chemo on 11/7/08.
CT scans on 12/2/08 & 2/25/09 - in remission!!!
Next scan in May 09.
Biker90's Journey
Jim's Space
"Patience is essential, attitude is everything."

Post Edited (biker90) : 3/13/2009 9:04:18 AM (GMT-6)


kreplerfp
Regular Member


Date Joined Oct 2008
Total Posts : 56
   Posted 3/13/2009 7:32 AM (GMT -6)   

 

Thanks Jim

My doc tells me to not use my levitra anytime near my injection. He`s made me concerned that the erection will last to long and might be to painfull. What would be a safe amount of levitra to take just before the injection. I have 20 mg levitra now which might be too much. Also since this will be my first injection should I use anything before it?

 

Fred

 


Diagnosed Feb 08
 
PSA 6.3
gleason 3+3
T2C
first biopsy 1 of 10 needles positive
surgery Sept 18 08
bone scan negative
evidence of sinus histiocytosis?
involvement of the margins identified at right and left apex and right anterior surface
also perineural invasion
no extraprostatic extention
no seminal vesicle invasion
tumor cells aggressive features of moderate to severe pleomorphism
1st PSA nov 08 undectable
kept left side bundle of nerves but lost some of the right side bundle
also had laser surgery in July 2008 to save eye sight from glaucoma hospitalized twice for kidney stones  in summer of 2008


biker90
Veteran Member


Date Joined Nov 2006
Total Posts : 1455
   Posted 3/13/2009 10:03 AM (GMT -6)   
Hey Fred,

If I was you, I would not take any other ED drugs before the first injection. My first injection was .1 cc and was WAY too much. I arrived at my combination of Viagra and Trimix after lots of experimentation and several very long duration erections. We are all different and have to experiment to find out what works for us. I use Viagra with Trimix because that way I can cut the Trimix dose way down. (.04 cc is only a few drops) When injecting drugs in my private parts, I feel that less is best...

Jim
Age 74. Diagnosed 11/03/06. PSA 7.05. Stage T2C Gleason 3+3.
RRP 12/7/06. Nerves and nodes okay.
Catheter out on 12/13/06. Dry on 12/14/06.
Pathological stage: T2C N0 MX. Gleason 3+4.
50 mg Viagra + .04 cc Trimix = Excellent Results
PSAs from 1/3/07 - 7/17/08 0.00.
PSA on 1/28/09 - 0.02
Lung cancer dxed on 5/16/08. Surgery on 6/25/08 T1N1M0 - Stage IIA Finished 4 cycles of chemo on 11/7/08.
CT scans on 12/2/08 & 2/25/09 - in remission!!!
Next scan in May 09.
Biker90's Journey
Jim's Space
"Patience is essential, attitude is everything."


kreplerfp
Regular Member


Date Joined Oct 2008
Total Posts : 56
   Posted 3/13/2009 5:34 PM (GMT -6)   

 

Hi Jim

Thanks for the advice. I checked and my uro did tell me to use .01 ml on the first injection and a then up to .03 ml after that.

Appreciate your help with this

Fred

 


Diagnosed Feb 08
 
PSA 6.3
gleason 3+3
T2C
first biopsy 1 of 10 needles positive
surgery Sept 18 08
bone scan negative
evidence of sinus histiocytosis?
involvement of the margins identified at right and left apex and right anterior surface
also perineural invasion
no extraprostatic extention
no seminal vesicle invasion
tumor cells aggressive features of moderate to severe pleomorphism
1st PSA nov 08 undectable
kept left side bundle of nerves but lost some of the right side bundle
also had laser surgery in July 2008 to save eye sight from glaucoma hospitalized twice for kidney stones  in summer of 2008


Tony Crispino
Veteran Member


Date Joined Dec 2006
Total Posts : 7582
   Posted 11/24/2009 5:50 PM (GMT -6)   
Above post edited and reported to Admin...

Tony
Prostate Cancer Forum Co-Moderator


W Burdine
New Member


Date Joined Dec 2009
Total Posts : 1
   Posted 12/27/2009 12:32 AM (GMT -6)   
James C, I live in Ocala Florida, where Frank's Pharmacy is located. The price I paid for Tri-Mix earlier this month was $80.50.
Since Medicare Part D will not cover this, it is a great expense as I am on a fixed income. If anyone knows of a less expensive place, please let me know.

Regards,

Wesley
WJBurdine@earthlink.net

MrGimpy
Veteran Member


Date Joined Jul 2009
Total Posts : 504
   Posted 12/27/2009 2:32 PM (GMT -6)   
My Dr told me not to take oral ED meds with the Trimix shot, not because it would cause excessively long erections, quite the opposite. The Oral meds would increase blood flow to the 2 cavernosa blood chambers of the penis, thus increasing the flush out rate of the Trimix.

Taking Viagra, Cialis or Levitra would likely result in a shorter erection when used with a Trimix Injection that if the Trimix were used alone
Stats:
Age: 52
PSA (2008)=1.9
Biopsy on Jan 09, 2009
One (1) out of twelve (12) cores was positive, plus external nodule found
Gleason Score = 3+3
Surgery (Da Vinci, robotic prostatectomy): 4/7/09
Removed Catheter: 04/19/09
100% bladder control - Pad free 7/09
PSA 7/09 undetectable, under .0


Redman55
Regular Member


Date Joined Jan 2010
Total Posts : 87
   Posted 1/31/2010 9:45 AM (GMT -6)   
I am now at .33 ml's and that appears to be my number. Now I just have to hope the aching pain subsides are fine tune it somehow.
PSA 8/2009 5.6 Gleason 8
DaVinci surgery 11/2009
Pathology - totally contained in margins -one bundle spared
PSA now undetectable
Continance: Night and morning fine; mid day onward still not there yet.
Trying Trimix


Worried Guy
Veteran Member


Date Joined Jul 2009
Total Posts : 3217
   Posted 1/31/2010 10:20 AM (GMT -6)   
I had a reaction to my first injection at the Uro's office with 0.15 of #1. My blood pressure dropped to 49/26 with none of the desired effects. They gave me an IV.

The low BP could have been due to my fear of needles, but I prefer to think it was because so much blood moved to my massive member causing brain starvation. (The key word there is "prefer".)

I had been taking 5mg of Cialis per day. My Uro told me to stop the Cialis and try the Trimix again 2 weeks later in their clinic . That will be this Friday. Yikes.
Jeff
DX Age 56. First routine PSA test on April 8th: 17.8. Start 2 weeks of Cipro to rule out protatitis.
May PSA: 22.6, 3 weeks later: PSA: 23.2.
Biopsy 6/10/09: 7/12 scores positive, 20%-70%, Gleason 6=3+3. Bone scan and C/T scan negative.
RP DaVinci -7/21/2009 @ Univ of Roch Medical Center
Left nerve gone, right partial spared.
Catheter removed - 7/31/2009 Pathology report received:
Gleason 3+4=7, Tumor size: 2.5 x 1.8 cm, location: both lobes and apex.
Extraprostatic extension present; Perineural invasion: present, extensive.
No Malignancy in Seminal Vesicle, vasa deferentia, lymph nodes 0/13
Prostate mass 56 grams. Pathologic Stage: pT3aN0MX
Post Surgery Status:
Potency - 12/11 5 months, Still no activity, zip. Using pump daily since 11/11. No effect with 20 mg of Cialis or 100 mg of Viagra. Shots next? See Uro 1/22/10 Trimix unsuccessful.
Incontinence - 8/20 4 full pads per day
.. 9/7 3-4 full pads per day (Try cutting down on fluids. Bad idea. I know.)
11/14 4 months: Still 3 pads per day. 420ml/day, 91 um leak.
12/11 5 months: Still 3 pads per day. 400-450ml/day
1/11/10 6 months: Still 3 pads but leak is now 320 ml (5 day avg.)
Post Surgery PSA - 9/3 6 weeks - 0.05; 10/13 3 months - 0.04, 6 months - 0.05.


MrGimpy
Veteran Member


Date Joined Jul 2009
Total Posts : 504
   Posted 1/31/2010 2:08 PM (GMT -6)   
1. pick up an auto injector and get the matching syringes, you will never see a needle enter your skin
2. go with either a 30 or 31 gauge needle, they are visibly thinner than even a 28 gauge
3. no need to take Levitra, it can actually reduces the effectiveness of your Trimix as the Levitra increases blood flow to the penis thus flushing out the Trimix faster
4. A compound pharmacy needs to be somewhat close so they can overnight the ice pack boxed vial
5. Start with 10units and work your way up slowly ( 2-4 units) at each application, keep some Sudafed (NOT PE version) always handy
6. Try other compound pharmacies near you to see if they are better at costing a 5ml vial
Stats:
Age: 52
PSA (2008)=1.9
Biopsy on Jan 09, 2009
One (1) out of twelve (12) cores was positive, plus external nodule found
Gleason Score = 3+3
Surgery (Da Vinci, robotic prostatectomy): 4/7/09
Removed Catheter: 04/19/09
100% bladder control - Pad free 7/09
PSA 7/09 undetectable, under .0


tanda35
New Member


Date Joined May 2009
Total Posts : 8
   Posted 2/3/2010 10:27 PM (GMT -6)   
Well, I guess I have to chime in with my nightmare with trimix. A few weeks ago at my Uro's office, he injected me with .20 ml (or is that cc?) of some low dose trimix. It barely took hold after 40 minutes and lasted at the 60% erection for only 10 minutes or so. He sent me home with a .25 and .30 dose and advised me to try the .25 dose and see how it works out and to call them and let them know. I waited until last Thursday (1/28) night to try it, figuring if things didn't work right, he would be in the office Friday to help me.
I injected at 9:40 p.m. and with in 10 minutes had a rock hard erection with a little pain. My girlfriend and I had our fun and after we were finished, the thing would not go away. Using "Saving your Sex Life after Prostate Cancer" as a reference, I took 4-30mg of Sudafed after two hours. Nothing happened. At 3 hours I called my Uro's office and the on call doc called me back pretty quickly and advised to ice it and if that didn't work, head to the emergency room. The ice didn't work, so off she and I go to the ER at 1 a.m. We sit until about 3 a.m. before the ER doc can see me. By this time I am worried about the tissue starting to die because of the lack of oxygen in the blood. He starts using syringes to withdraw blood while injecting the epinephrine solution. He got one side down and then the 2nd side down an hour later. I left at 5:30, bruised but intact and a limp penis. (The whole time I was in the exam room, my penis ached like hell).
Went home and caught a few hours sleep and called my Uro when I woke up. He said to stop in that afternoon. When he finally saw me, he said no more injections for me due to the priapism. It was only a fill in appointment, so I didn't really have time to discuss anything with him, so I will have to do at a later date.
My question is. If the .20 ml didn't work all that well in the office, why would the .25 go way over board and cause the priapism? Doesn't make any sense to me. I had no manual stimulation by my girlfriend, by the way, it just got hard on it's own. I really enjoyed the great erection and would like to continue the injections, but without the priapism. But that may be an uphill battle with him.
Anyone have any opinions on this?

Gleason, 4+3; PSA, 7
Robotic Prostatectomy 4/09, nerves both sides spared, post surgery analysis confirmed 3+4 Gleason,
cancer contained, no penetration, lymph nodes clear
6 week and 4 month PSA <0.1, continent at 4 months. Impotent at 4 months still. No nocturnal erections.

 

 


hb2006
Regular Member


Date Joined Nov 2008
Total Posts : 297
   Posted 2/3/2010 10:38 PM (GMT -6)   

I had a similar response to Caverject and Edex. The .20 ml/cc dosage got me to only 75%. But when I went to .25ml or .30ml, I would stay hard for almost 4 hours. Never had to go to the ER, but it was close. I did discover that if you lay on your back in the tub with hot water and your feet in the air, against the wall. It would slowly go down.

You don't want to walk around after injecting because it seems to re-activate things, especially in the second hour. Other guys will respond, I'm sure.

 


Age 60, PSA 2007 4.1, PSA 2008 10.0
Diagnosed April 2008, Biopsy: 6 of 12 cores positive, Gleason 4 + 5 = 9
CT and Bone Scan negative, Open surgery at Shawnee Mission Medical Center May 21, 2008
Right side nerves spared, Radical prostatectomy and lymph node dissection
Cather removed on June 3rd, totally dry on July 9th, pT2c, lymph nodes negative
PSA Sept 28, 2008 0.00, PSA Jan 22, 2009 0.00, PSA June 29, 2009 0.00
ED Status- Currently using Trimix, Levitra daily for increased blood flow.
Noctural Erections have completely returned on a nightly basis, same hardness as before.


ASmith7
New Member


Date Joined Aug 2011
Total Posts : 1
   Posted 8/12/2011 12:56 AM (GMT -6)   
Over the past 2 years, I have self-injected Trimix hundreds of times. So I have a lot of experience using the medication in varying doses and concentrations, as well as injection technique.

Without the correct injection technique, you do risk injury to your penis, whether temporary or permanent. Fortunately, I have never permanently injured my penis using Trimix, although I have frequently developed temporary and painful inflammation of the corpora casernova such that a small painful bump develops at the injection site. The bump lasts a couple of days and then goes away, but it's painful and there is a technique to avoid this kind of temporary injury.

The best technique I have found is to use a vacuum erection device (penis pump) prior to injecting Trimix. Doing so introduces blood into the corpora casernova, which produces an erection. You want to inject Trimix into a semi-erect penis, NOT into a flaccid penis. So to get a semi-erect penis, use the penis pump. Keep the tensioner ring (cock ring) at the base of the penis after you pump, then inject in either the 3 or 9 o'clock position. It's also very important that you apply an alcohol swab with finger pressure to the injection site immediately after injecting--and hold it there for 4-5 minutes. This will keep a bump from developing, as well as stop any minor bleeding from the injection site. After 4-5 minutes, discard the alcohol swab and remove the cock ring. By this time, you will have a very nice erection and one that is not painful. I also place a gel cock ring around the penis and testicles to keep the medication in the penis from back-flowing. This will enable you to keep a good erection for at least an hour. It also feels really good when you're having sex.

I have to say that Trimix and this particular injection technique has changed my sex life and view of ED. It's as if I'm 18 again. Yeah, I still have ED, but at least it's well treated and I can enjoy sex with my wife like we had in our younger days.
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