Post Edited (wiggyann) : 6/26/2009 3:26:03 PM (GMT-6)
Father died from poorly differentiated PCa @ 78 - normal PSA and DRE
5 biopsies over 4 years negative while PSA going from 3.8 to 28
Dx Nov 2007, age 46, PSA 29, Gleason 4+4=8
Decided to participate in clinical trial at Duke - 6 rounds of chemo (Taxotere+Avastin)
PSA results: 1/8/2008-33.90, 1/11/2008-29.50, 1/31/2008-38.20,
2/21/2008-32.00, 3/13/2008-26.20, 4/3/2008-26.60, 4/24/2008-20.60
RRP at Duke (Dr. Moul) on 6/16/2008
Pathology: Gleason downgraded 4+3=7, Duke: T2c N0MX, one positive margin,
2nd opinion at Sloan Kettering: T3a N0MX, extraprostatic extension, two positive margins
PSA undetectable for 8 months, then 2/6/2009-0.10, 4/26/2009-0.17, 5/22/2009-0.20, 6/11/2009-0.27
6 Months ADT: Casodex started 6/12/2009, Lupron 6/22/2009
IMRT to start mid-Aug
I did not have the seeds but did have IMRT. At the time my oncologist told me that anything under a 1.0 and steady was good results for radiation. The bounce, if it occurs, is usually between 18 and 24 months but can be as far out as three years according to some sources. One research paper indicated that post radiation nadir below .5 and two years to nadir had the best results for long term. Based on that I would say things look good for your husband.
As Geebra stated, and as my oncologist noted, there is still some viable prostate tissue after the treatment and it will express PSA.
Here's hoping for continued improvement and good health to your husband and you.
64 years old.
PSA rising for 10 years to 40, free psa 10-15. Had 5 urologists, 12 biopsies and MRIS all neg. Doctors DX BPH and continue to get biopsies yearly. Positive Biopsy in 10-08, 2 cores of 25, G6 less than 5%. Scheduled Surgery as recommended.
2nd Opinion from Dr Sholtz, an Oncologist said DX wrong, path shows indolant cancer, but psa history indicates large cancer or metastasis. Futher tests and Color Doppler confirmed large transition zone tumor that 13 biopsies and MRIS missed. G 4+3 approx 2.5cm diameter.
Combidex MRI in Holland eliminated lymphnode mets. Casodex and Proscar reduced psa to 0.6 and prostate from 60mm to 32mm. Changed diet, no meat and dairy.
Seed implants on 5-19-09, 3 hours door to door, no pain, minor side affects are frequency and burining urination. Daily activities resumed day after implants.
Scheduled for 5 weeks IMRT in July
You're doing fine - at least in my opinion. We survived the dreaded bounce and as you can see from "our" results, we're continuing on as usual until we have reason not to. This whole thing has given us new reasons to celebrate things "just because".