MUSE 500 Mgs...Has anyone used this Pellet for ED?

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unhappycramper
Regular Member


Date Joined Nov 2005
Total Posts : 113
   Posted 7/30/2009 2:47 PM (GMT -6)   
I'm curious. I had a nerve-sparing radical prostatectomy last January of 2009.(I've posted elsewhere on this site about that) 6-1/2 months out, and not surprising that I still can not achieve an erection. The thought of inserting a needle with Trimax or any other substance into my penis is unnerving,but to insert a small pellet into my urethra is even more so. The doc said it does not hurt and there could be side effects. One could be burning sensation,and the other is maintaining an erection for more than four hours, in which case you sit in a bathtub of ice water or place an ice bag on the area, or just go to the ER.

What it is.
MUSE
A new treatment for erectile dysfunction is MUSE (Medicated Urethral System for Erections). This is approved for use in Canada. The pellet is Prostaglandin and it is deposited into the penis via the urethra (urine tube). There are 3 doses: 250 mg, 500 mg and 1,000 mg. MUSE has a success rate of 60%. It is an easy method of treatment for those who do not wish to use injections. http://www.malehealth.com/HTML/B4e2.html#MUSE

goodlife
Veteran Member


Date Joined May 2009
Total Posts : 2612
   Posted 7/30/2009 4:35 PM (GMT -6)   
I think it was prescribed for Corvetteman, but haven't heard if he tried it !
Age 58, PSA 4.47 Biopsy - 2/12 cores , Gleason 4 + 5 = 9
Da Vinci, Cleveland Clinic  4/14/09   Nerves spared
0/23 lymph nodes involved  pT3a NO MX
Catheter and 2 stints in ureters for 2 weeks due to anatomical issues with location of ureters with respect to bladder neck.  Try 3 tubes where no tubes are supposed to be for 2 weeks !
Neg Margins, bladder neck negative
Living the Good Life, cancer free  6 week PSA  <.03
3 month PSA <.01 (different lab)


Paul1959
Veteran Member


Date Joined Nov 2007
Total Posts : 597
   Posted 7/30/2009 4:58 PM (GMT -6)   
It is a very common first approach if the oral meds do not work. It works in about 40% of men, which in ED circles is pretty good. My Doc prescribed it for me, but I never used it. A guy in my support group did use it and did not like the ache. You insert the lubed tube about 1.5 inches into your penis. Push a plunger and the pill slides into the urethra. You then massage it and walk around a bit while the tablet dissolves. You erection ideally lasts about 45-60 mins. If it works for you, it is great.
Here is a video link. http://www.drrajmd.com/multimedia/video/vid.htm
Paul
46 at Diagnosis.
Father died of Pca 4/07 at 86.
10/07 PSA 5.06 (Biopsy 11/07 1 of 12 with 8% involvment) (1mm)
Da Vinci surgery Jan 5, '08 at Mt. Sinai Hosp. NYC www.roboticoncology.com
Saved both nerve bundles.
Path Report: Stage T2cNxMx
-Gleason (3+3)6
Pad free on March 14 - (10 weeks.) Never a problem since.
ED - at one year, ED is fine with viagra.
One year PSA - undectable!

ED Website: www.FrankTalk.org - frank discussions of Erectile Dysfunction - check it out.


Cajun Jeff
Veteran Member


Date Joined Mar 2009
Total Posts : 3620
   Posted 7/30/2009 6:46 PM (GMT -6)   
Unhappy: We can compare notes in the near future. I am going tomorrow to bring my script to pharmacy. I will not be able to get them till Monday. No one stockes this anymore here in Baton Rouge. Pharmacist said they quit stocking it after the pills became available. Viagra etc. My Dr. said I neded to try this before we start injections so here we go. $200 test drive. I guess that is the cost for admissions!!!!!

I do hope that I can report good results. I will let you guys know. My Dr. said less invasive and in his opinion this needs to be the next try before injections.

He also said I could use the MUSE with the pills for a double push...

Jeff
Jeff T Age 57
9/08 PSA 5.4, referred to Urologist
9/08 Biopsy: GS 3/4=7
10/08 Nerve sparing open RRP- Path Report: GS 3+3=7 Stg. pT2c, margins clear
3 mts: PSA .05 undetectable
 10th month  PSA <0.01
ED- 5 mg Cialis daily, pump daily, going to try MUSE next


Purgatory
Elite Member


Date Joined Oct 2008
Total Posts : 24150
   Posted 7/30/2009 7:41 PM (GMT -6)   
Jeff, you are a brave man indeed, the thought of forcing something else up my urethra right now makes my hair stand on end. If it works for you, it should be worth the cost and effort on your end, and I hope it does.
Age 57, 56 at DX, PSA 7/7 5.8, 7/8 12.3,9/8 14.5
3rd Biopsy Sept 08: Positive 7 of 7 cores, 40-90%, Gleason 7, 4+3
Open RP surgery 11/14/8, Right nerves spared, 4 days hospital, staples out 11/24/8, 5th cath out on 1/19/9
 Pathlogy Report:Gleason 3+4=7, pT2c, 42 grm, tumor 20%, Contained in capsule, one post. margin, clear lymph nodes 
2009 PSA   2/9 .05, 5/9 .10, 6/9 .11, 8/11 ?
Lastest 7/13 met with Rad. Oncl, considering options, 7/20 Catheter #6 after complete blockage, scarring closed up bladder neck, again
 
 


Piano
Veteran Member


Date Joined Apr 2008
Total Posts : 845
   Posted 7/30/2009 7:53 PM (GMT -6)   
I admit the the thought of shoving that little pellet up there is scary, even to someone who is now well used to injections. Good luck with the MUSE guys, and please do keep us posted.

Even if you have no success with MUSE, do consider injections. Auto-injectors can remove a lot of the trepidation, and I take the coward's way out -- turn away while my wife administers the injection. Foreplay with a difference :-)
Pre-op:
Age 63 at diagnosis, now 64.
No symptoms; PSA 5.7; Gleason 4+5=9; cancer in 4 of 12 cores.
Operation:
Non-nerve sparing RRP on 7 March 2008.
Two nights in hospital; catheter out after 7 days.
Post-op:
Continent; no pads needed from the get-go.
Pathology showed organ confined and negative margins. Gleason downgraded to 4+4=8.
PSAs:
6-week : <0.05
7-month: <0.05
13-month: 0.07 (start of a trend?)
ED:
After a learning curve, Bimix injections (0.2ml) are working well. VED also works but we find it inferior to Bimix.


JStars
Regular Member


Date Joined Oct 2005
Total Posts : 453
   Posted 7/30/2009 11:31 PM (GMT -6)   
Hey Camper,

I have the MUSE in the fridge right now -- first trial at the Doc's office on the 7th.
So far for me the regular ED pills have not really done much so it will be interesting to see if MUSE does better.
Also have been diligently pumping once or twice a day for months now -- hopefully that will be a help.
I hear having an erection after having none for months can be a pain -- alprostadil or no ...

Ever the optimist, I have asked my wife to come along, just in case I cannot drive afterwards -- hah hah hah.

(Hmm the warning actually does say not to drive within one hour of taking MUSE -- lightheadedness possible -- ok)

Also a 4 pack x 1000mg dose was only $31(my cost) with insurance -- i was surprised it was that inexpensive (relatively speaking).
Age 58, 195lbs, 6'4", 57 at DX, PSA Aug2008 7 4 ... June2007 4.7 (BPH + LUTS)
Biopsy Nov2008 1 of 12 cores 5%, Gleason 3+3 - Sona showed size 140+ cc (110 grams post op).
02/03/09 open RRP surgery , Nerve sparing both sides, 1 day in hospital, Day 4 first BM,
Pathology Report: All margins clear - No Invasive spread - no change in Gleason score.
02/18/09 Cath out, passed a 1cm oblong STONE within hours.
03/06/09 Started Levitra@20mg / Viagra@100mg / (04/01) Cialis@20mg -- no real effect (thru 07/2009).
04/01/09, 07/07/09 PSA <0.1 - Stone Was Oxalate stone -- X-ray showed no additional stones.
Next up (so to speak) -- MUSE(1000mg) -- on 08/07/09.

Post Edited (JimStars) : 7/30/2009 10:34:55 PM (GMT-6)


IdahoSurvivor
Veteran Member


Date Joined Aug 2007
Total Posts : 1015
   Posted 7/30/2009 11:36 PM (GMT -6)   
Muse can be effective for some individuals. From my experience, you need to follow the instructions to the letter to get the most out of the prescription. If you find that the 500mg is not effective, there is also a 1000mg dose.

I believe the injections can be more effective and more reliable than the Muse. However, if you don't like the idea of injecting yourself and have some worries about developing Peyronie's disease, Muse could be a good alternative.

I wish you the best in your attempt.

Barry
Da Vinci LRP July 31, 2007… 54 on surgery day
PSA 4.3 Gleason 3+3=6 T2a Confined to Prostate
6th PSA 06/09 still less than 0.1


Mavica
Regular Member


Date Joined Jun 2008
Total Posts : 375
   Posted 7/31/2009 12:05 PM (GMT -6)   
Not long after my surgery last September my Urologist/Surgeon prescribed for me a regime of Cialis and MUSE (250 strength), to be used simultaneously.  I've suffered no side effects and I'm considering asking for a stronger dose when I next visit the Urologist.  Erections have been better/stronger with the MUSE than with the Cialis alone.  I haven't used the MUSE as often as my Urologist would like, however, and I'm trying to remember to keep using it.  The MUSE applicator has been very easy to use and together with the MUSE the Urologist prescribed Lidocaine gel in the event there was some discomfort or pain.  Sometimes I use the Lidocaine, sometimes not.

Age:  59 (58 at diagnosis - June, 2008)

April '08 PSA 4.8 ("free PSA" 7.9), up from 3.5 year prior

June '08 had biopsy, 2 days later told results positive but in less than 1% of sample

Gleason's 3+3=6

Developed sepsis 2 days post-biopsy, seriously ill in hospital for 3 days

Dr. recommended robotic removal using da Vinci

Surgery 9/10/08

Northwestern Memorial Hospital, Chicago, IL

Dr. Robert Nadler, Urologist/Surgeon

Post-op Gleason's:  3+3, Tertiary 4

Margins:  Free

Bladder & Urethral:  Free

Seminal vesicles:  Not involved

Lymphatic/Vascular Invasion:  Not involved

Tumor:  T2c; Location:  Bilateral; Volume:  20%

Catheter:  Removed 12-days after surgery

Incontinent:  Yes (1/2 light pads per day)

Combination of Cialis and MUSE (alprostadil) three times weekly started 9-27-08

Returned to work 9-29-08 (18-19 days post-op)

PSA test result, post-op, 10/08: 0.0; 12/08: 0.0; 4/09: 0.0

 


alex1
Regular Member


Date Joined May 2008
Total Posts : 27
   Posted 7/31/2009 1:43 PM (GMT -6)   
I've used 250 mg Muse for about the last six months, and each time I've used it following the directions specifically it has worked. My experience has been that if used properly it does the job. Some observations (which may be more detailed than you would like) :
(1) Administering it is far better than it sounds like it would be-really no problem except in your head, but be sure to give it the "warm-up" time after it comes out of the frig so that pellet will both release from the applicator and dissolve better in the urethra. Also, it is important that you urinate immediately before application so the urethra is moist when you apply.
(2) The really mean it when they instruct you to stay in a sitting or standing position for a time after administering. Even though these positions are not often compatible with your intended use of the product, I have found that the drug flows out of its intended receptacle pretty quickly if you spend much time on your back, resulting in loss of effectiveness at a very inconvenient time.
(3) There is an ache with it-not bad, but noticeable. Certainly not enough to discourage use.
(4) The biggest drawback is that like with most ED remedies, you have to plan ahead, so spontaneity becomes a thing of the past.
(5) Unlike pills, most insurance companies give you no problem about it. Mine pre-approved 24 doses for one co-pay of $50. I guess they figure if you're willing to do what it requires of you to use it, you're probably not a purely "recreational" user.
58-year old attorney, no family history of PCa
Biopsy 12/29/2007 with 1 of thirteen samples positive; estimated 5% involvement
3+3=6 Gleason
TR2C Stage
RRLP on 2/21/2008 with excellent prognosis (no evidence;margins and other tissue clear) on cancer clearance and sparing of both nerve bundles
Post-OP:Actual involvement 15%, one lobe only; PCa fully contained in prostate-no involvement with other tissues and margins clear
Catheter out on 3/2/2008; fully continent by 3/31/2008
Undetectable PSA on 3/31/2008
Working on ED: 20MG Levitra every other day; Vacuum pump almost daily; some improvement, but not there yet. Started using MUSE with some success, 11/1/2008
2d undectable PSA on 7/21/2008
3d undectable PSA on 10/30/2008


Cajun Jeff
Veteran Member


Date Joined Mar 2009
Total Posts : 3620
   Posted 7/31/2009 4:29 PM (GMT -6)   
I will pick up my 6 pellets on Monday morning. Insurance "Big Blue" Not covering.. $200. I do hope it works. I read the post by Alex. That is helpfull. Hope to have a good report next wk.
Jeff T Age 57
9/08 PSA 5.4, referred to Urologist
9/08 Biopsy: GS 3/4=7
10/08 Nerve sparing open RRP- Path Report: GS 3+3=7 Stg. pT2c, margins clear
3 mts: PSA .05 undetectable
 10th month  PSA <0.01
ED- 5 mg Cialis daily, pump daily, going to try MUSE next


unhappycramper
Regular Member


Date Joined Nov 2005
Total Posts : 113
   Posted 8/2/2009 11:38 AM (GMT -6)   
Hi,
I have been taking 25mgs Viagra since the Radical Prostatectomy. I saw my urologist this past Thursday. He told me now I should start taking full 100mgs pills. I did that for three days,but at $11.00 per pill,I'm not going to go broke trying to get my hardness back. Did not work,even looking at playboys and reading penthouse.
With this craze of shaving one self for hygiene and just because it looks cool and different, I did so to see what that region would look like, since I've been told it actually makes Mr. Happy"" appear bigger. I guess they meant when one could achieve an erection,but not in my case. (Plus I've heard that when the prostate is removed, the area just above where the penis comes out creates a void or an indentation.
My Doctor told me this is unlikely, but also told me my Mr. Happy actually looks smaller than before the surgery...WHAT? Thanks for the input ,doc,that makes me feel even more of a man besides, he's a pee pee doc and looks at penises all day long, how does he remember what size I looked like 6-1.2 months ago. To me, it looks the same before the surgery and now after surgery.
My insurance does not cover Viagra, and I don't think it's going to cover the MUSE, and I'm onboard with all of you that are squeamish about inserting any foreign object at all into our male members.That would make Mr. happy, very unhappy.

The rules have got to change concerning insurance coverage of Viagra. The company will certainly, without hesitation, cover newly UNEMPLOYED guys as of last January 2009,but WILL NOT COVER PATIENTS OF RADICAL PROSTATECTOMIES! C'mon, we did not ask for this surgery,and we want to enjoy sex and please our women just like they do. I've appealed three times with my insurance, but no dice. Reminds me of our mighty justice system, or lack thereof.....it's unfair,unjust,and mostly disgusting what people get away with!

Post Edited (unhappycramper) : 8/2/2009 10:41:51 AM (GMT-6)


goodlife
Veteran Member


Date Joined May 2009
Total Posts : 2612
   Posted 8/2/2009 3:52 PM (GMT -6)   
unhappy

Lokk up the All Day Chemist websit !
Age 58, PSA 4.47 Biopsy - 2/12 cores , Gleason 4 + 5 = 9
Da Vinci, Cleveland Clinic  4/14/09   Nerves spared
0/23 lymph nodes involved  pT3a NO MX
Catheter and 2 stints in ureters for 2 weeks due to anatomical issues with location of ureters with respect to bladder neck.  Try 3 tubes where no tubes are supposed to be for 2 weeks !
Neg Margins, bladder neck negative
Living the Good Life, cancer free  6 week PSA  <.03
3 month PSA <.01 (different lab)


Cajun Jeff
Veteran Member


Date Joined Mar 2009
Total Posts : 3620
   Posted 8/4/2009 5:02 PM (GMT -6)   
The Box is in the fridge....Any of you guys us the MUSE with the viagra. Are skip the pill if useing NUSE.

don't want to go with a 6 hr erection :)
Jeff T Age 57
9/08 PSA 5.4, referred to Urologist
9/08 Biopsy: GS 3/4=7
10/08 Nerve sparing open RRP- Path Report: GS 3+3=7 Stg. pT2c, margins clear
3 mts: PSA .05 undetectable
 10th month  PSA <0.01
ED- 5 mg Cialis daily, pump daily, going to try MUSE next


Paul1959
Veteran Member


Date Joined Nov 2007
Total Posts : 597
   Posted 8/4/2009 10:10 PM (GMT -6)   
Unhappy Cramper.
It is funny, but many of the guys in my PCa groups have shaved since surgery. We had noticed that most men under 50 now "manscape". my wife likes it much better. Once we woke up from surgery with all the hair gone, it was easier just to keep it gone. It's a lot of work to stay hip! LOL
Paul
46 at Diagnosis.
Father died of Pca 4/07 at 86.
10/07 PSA 5.06 (Biopsy 11/07 1 of 12 with 8% involvment) (1mm)
Da Vinci surgery Jan 5, '08 at Mt. Sinai Hosp. NYC www.roboticoncology.com
Saved both nerve bundles.
Path Report: Stage T2cNxMx
-Gleason (3+3)6
Pad free on March 14 - (10 weeks.) Never a problem since.
ED - at one year, ED is fine with viagra.
One year PSA - undectable!

ED Website: www.FrankTalk.org - frank discussions of Erectile Dysfunction - check it out.


Cajun Jeff
Veteran Member


Date Joined Mar 2009
Total Posts : 3620
   Posted 8/5/2009 8:55 PM (GMT -6)   
Just an update: Administering the pellet was as simple as could be. That is a bit is ache but the requested event did not happen. Very dissapointed!!!!!!

Also might as a bit of agner just not sure where to place that anger!!!!! And lots of frustration!!!


Jeff
Jeff T Age 57
9/08 PSA 5.4, referred to Urologist
9/08 Biopsy: GS 3/4=7
10/08 Nerve sparing open RRP- Path Report: GS 3+3=7 Stg. pT2c, margins clear
3 mts: PSA .05 undetectable
 10th month  PSA <0.01
ED- 5 mg Cialis daily, pump daily, going to try MUSE next


Purgatory
Elite Member


Date Joined Oct 2008
Total Posts : 24150
   Posted 8/5/2009 9:14 PM (GMT -6)   
Sorry it didnt work on the first try, are you going to try again, or move on to some thing else? Vent all your anger at Prostate Cancer, it's an evil thing.

I would have thought it would be difficult to insert it, but you said it was easy.

David
Age 57, 56 at DX, PSA 7/7 5.8, 7/8 12.3,9/8 14.5
3rd Biopsy Sept 08: Positive 7 of 7 cores, 40-90%, Gleason 7, 4+3
Open RP surgery 11/14/8, Right nerves spared, 4 days hospital, staples out 11/24/8, 5th cath out on 1/19/9
 Pathlogy Report:Gleason 3+4=7, pT2c, 42 grm, tumor 20%, Contained in capsule, one post. margin, clear lymph nodes 
2009 PSA   2/9 .05, 5/9 .10, 6/9 .11, 8/11 ?
Lastest 7/13 met with Rad. Oncl, considering options, 7/20 Catheter #6 after complete blockage, scarring closed up bladder neck, corrective laser surgery scheduled for 8/18
 
 


Cajun Jeff
Veteran Member


Date Joined Mar 2009
Total Posts : 3620
   Posted 8/6/2009 10:00 AM (GMT -6)   
I will try again just going to wait for the best time. Next adventure will be 1 hr after I take my cialis pill. Lets try a double wammy!!!!
Jeff T Age 57
9/08 PSA 5.4, referred to Urologist
9/08 Biopsy: GS 3/4=7
10/08 Nerve sparing open RRP- Path Report: GS 3+3=7 Stg. pT2c, margins clear
3 mts: PSA .05 undetectable
 10th month  PSA <0.01
ED- 5 mg Cialis daily, pump daily, going to try MUSE next


Purgatory
Elite Member


Date Joined Oct 2008
Total Posts : 24150
   Posted 8/6/2009 10:36 AM (GMT -6)   
Jeff, if that doesn't wake up your weiner, then you ought to take it out back and shoot it, just kidding. Sounds like a plan though. Good luck and happy hunting.
Age 57, 56 at DX, PSA 7/7 5.8, 7/8 12.3,9/8 14.5
3rd Biopsy Sept 08: Positive 7 of 7 cores, 40-90%, Gleason 7, 4+3
Open RP surgery 11/14/8, Right nerves spared, 4 days hospital, staples out 11/24/8, 5th cath out on 1/19/9
 Pathlogy Report:Gleason 3+4=7, pT2c, 42 grm, tumor 20%, Contained in capsule, one post. margin, clear lymph nodes 
2009 PSA   2/9 .05, 5/9 .10, 6/9 .11, 8/11 ?
Lastest 7/13 met with Rad. Oncl, considering options, 7/20 Catheter #6 after complete blockage, scarring closed up bladder neck, corrective laser surgery scheduled for 8/18
 
 


alex1
Regular Member


Date Joined May 2008
Total Posts : 27
   Posted 8/6/2009 10:44 AM (GMT -6)   
At the risk of being repetitive, several things I have found in dealing with MUSE:
(1) make sure you give it time to warm up;
(2) after administering, spend a pretty good bit of time (and effort) massaging it in to get it distributed;
(3) be sure to remain in a sitting up or standing position until you see substantial results;
(4) at times, it has taken 30 minutes or so to take effect;
(5) do use in conjunction with viagra, etc., following instructions carefully for both drugs when administered (particularly on drinking and empty stomach);
(6) use of any form of outside stimuli is also good to take away some of the "clinical" feeling and make the whole experience a little bit more sexual.

You probably already know this pretty well, but patience seems to be the biggest thing we are all learning through this. You might also want to consider moving up to the 1000mg dosage if the side effects are not causing much problem for you.
58-year old attorney, no family history of PCa
Biopsy 12/29/2007 with 1 of thirteen samples positive; estimated 5% involvement
3+3=6 Gleason
TR2C Stage
RRLP on 2/21/2008 with excellent prognosis (no evidence;margins and other tissue clear) on cancer clearance and sparing of both nerve bundles
Post-OP:Actual involvement 15%, one lobe only; PCa fully contained in prostate-no involvement with other tissues and margins clear
Catheter out on 3/2/2008; fully continent by 3/31/2008
Undetectable PSA on 3/31/2008
Working on ED: 20MG Levitra every other day; Vacuum pump almost daily; some improvement, but not there yet. Started using MUSE with some success, 11/1/2008
2d undectable PSA on 7/21/2008
3d undectable PSA on 10/30/2008


Cajun Jeff
Veteran Member


Date Joined Mar 2009
Total Posts : 3620
   Posted 8/6/2009 10:53 AM (GMT -6)   
Oh yes I have upped to 100mg....I hope the next try will be better...
Jeff T Age 57
9/08 PSA 5.4, referred to Urologist
9/08 Biopsy: GS 3/4=7
10/08 Nerve sparing open RRP- Path Report: GS 3+3=7 Stg. pT2c, margins clear
3 mts: PSA .05 undetectable
 10th month  PSA <0.01
ED- 5 mg Cialis daily, pump daily, going to try MUSE next


JStars
Regular Member


Date Joined Oct 2005
Total Posts : 453
   Posted 8/7/2009 10:41 PM (GMT -6)   
Hey CV-Man,

I am just done with my first shoot with MUSE also. That was at the Uro's Office as he wanted to show how to do the insert (not a direct slide in but gently rock the tube back and forth and slight in and out so as not to scratch or irritate the urethra lining or cause a burning sensation). And as i was mentioning that I should urinate first he said, yes, and then hit the button anyways. (My Uro always triple books appointments and is always in a hurry -- not a great Doc if you want to discuss anything in detail or anything at all in fact). At any rate over the course of 10 minutes, with constant manipulation while mostly sitting it had risen to about 80 or 90%. And as I mentioned above, the 4-5 months of pumping has made for impressive girth too.

So he checked for firmness and declared it good and sent me on my way. Too bad it was a 20-25 minute ride home. While it was still tumescing it was not really usable for intercourse -- much to our disappointment.

Also the Alprostadil Ache was apparent -- not unlike the dull ache you would get from a long early morning nocturnal erection combined with a full bladder -- you remember those right?? The ache started to go away exactly 1 hour after insertion of the pellet.

Oh i should mention that because the Doc pulled the trigger before I urinated -- I had to go right after I left his office so that might have had an adverse effect of flushing some of the pellet out.

All in all not a great first outing, but will get it all right next time. Will probably try a Viagra or Cialis (and hour or two before the MUSE) combo next time (the doc recommended that as well).
Age 58, 195lbs, 6'4", 57 at DX, PSA Aug2008 7 4 ... June2007 4.7 (BPH + LUTS)
Biopsy Nov2008 1 of 12 cores 5%, Gleason 3+3 - Sona showed size 140+ cc (110 grams post op).
02/03/09 open RRP surgery , Nerve sparing both sides, 1 day in hospital, Day 4 first BM,
Pathology Report: All margins clear - No Invasive spread - no change in Gleason score.
02/18/09 Cath out, passed a 1cm oblong STONE within hours.
03/06/09 Started Levitra@20mg / Viagra@100mg / (04/01) Cialis@20mg -- no real effect (thru 07/2009).
04/01/09, 07/07/09 PSA <0.1 - Stone Was Oxalate stone -- X-ray showed no additional stones.
Next up (so to speak) -- MUSE(1000mg) -- on 08/07/09.

Post Edited (JimStars) : 8/8/2009 7:46:43 PM (GMT-6)


Cajun Jeff
Veteran Member


Date Joined Mar 2009
Total Posts : 3620
   Posted 8/7/2009 10:59 PM (GMT -6)   
Jim: you have no idea how much I appreciate you honest post. I will give it another try. I will also make sure I have my hi-dose Cialis working when I slip the little stick in the D---. It is just so darn frustrating...... Thanks for you post...
Jeff T Age 57
9/08 PSA 5.4, referred to Urologist
9/08 Biopsy: GS 3/4=7
10/08 Nerve sparing open RRP- Path Report: GS 3+3=7 Stg. pT2c, margins clear
3 mts: PSA .05 undetectable
 10th month  PSA <0.01
ED- 5 mg Cialis daily, pump daily, going to try MUSE next


JStars
Regular Member


Date Joined Oct 2005
Total Posts : 453
   Posted 9/8/2009 8:41 AM (GMT -6)   
Just a new update on the Amazing Technicolor Dreamjourney with MUSE.
For our third try last night I decided to incorporate the following advice:

1: Take full dose of Cialis a little while before inserting MUSE. (Did about 30 mins before).

2: Do some pre-plumping with the pump and put on a single, not too tight ring -- only
pumped to 50-60%.

3: Warmed up the MUSE package for a few minutes (on top of the bedside lampshade).

For the first ten minutes after insert, started to get some added firmness, but seemed like it was going to be the SameOld, SameOld and not get hard enough for actual use. Was standing for most of this time working/stimulating.

It looked like the ring was starting to constrict off blood supply a little too much so I took it off and after a minute or two, WHOOSH, the Alprostadil must have diffused in one gush and we had an erection just like old times -- more than adequate for penetration etc etc etc.

Cut to next scene ... (visualize relaxing and having a smoke in bed -- not really). So, one or all of the three items above might have made the difference. I wonder which it is? I hate to waste a MUSE trying to figure it out.

Also, the effect lasted well into 1.5 hours of very usable erection, even when lying flat trying to ignore it (yeah right). Even after 2 hours (and deflating slowly) if I got up and started walking it would harden back up again. Of course wife was long ago, fast asleep. Next time have to really plan ahead so we can have a lot more of the allotted time available to do whatever needs doing. And hey, NO refractory, recovery time either after orgasm -- when's the last time anyone had THAT happen (without help)?

I am thinking maybe 1000 mcg MUSE might be a little too strong also (but it could be the Cialis kicking in helping too). Too bad I can't cut the pellet in half to get more shots out of the prescription!

Hope this might give people some additional ideas to try.
Age 58, 195lbs, 6'4", 57 at DX, PSA Aug2008 7 4 ... June2007 4.7 (BPH + LUTS)
Biopsy Nov2008 1 of 12 cores 5%, Gleason 3+3 - Sona showed size 140+ cc (110 grams post op).
02/03/09 open RRP surgery , Nerve sparing both sides, 1 day in hospital, Day 4 first BM,
Pathology Report: All margins clear - No Invasive spread - no change in Gleason score.
02/18/09 Cath out, passed a 1cm oblong STONE within hours.
03/06/09 Started Levitra@20mg / Viagra@100mg / (04/01) Cialis@20mg -- no real effect (thru 09/2009).
04/01/09, 07/07/09 PSA <0.1 - Stone Was Oxalate stone -- X-ray no stones.
08/07/2009 - MUSE@1000mcg@Uro Office -- worked OK -- AlProstadil ache not bad.

Post Edited (JimStars) : 9/8/2009 8:19:30 AM (GMT-6)


James C.
Veteran Member


Date Joined Aug 2007
Total Posts : 4452
   Posted 9/8/2009 9:30 AM (GMT -6)   
Jim, if it were me, I would expect the difference was the pump and ring, if anything. Using them holds some small of blood in the cavities and allowed the drug to fully adsorb in the tissues before removing the ring and allowing the full effect of the blood flowing into the drugged and constricted penis apparatus. Using a ring holds the blood and the drug in the penis, so you will get much better adsorption, IMO...I suspect that you could have the same results next time if you didn't do the pill, but just the pump, ring and Muse.
James C. Age 62
Co-Moderator- Prostate Cancer Forum
4/07 PSA 7.6, referred to Urologist, recheck 6.7
7/07 Biopsy: 3 of 16 PCa, 5% involved, left lobe, GS 3/3=6
9/07 Nerve sparing open RRP 110gms.- Path Report: GS 3+3=6 Stg. pT2c, 110gms, margins clear
22 mts: ED- 50 mg Viagra 3X week, pump daily,Trimix 30/1/20-.05ml 2X week continues
PSA's: .04 each test since surgery

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