TRIMIX GEL experiences

A few people were asking about how Trimix Gel compares with MUSE.

I have used both now. Also cost for Trimix Gel was around $150 for 6 doses (Oct 2009) -- pretty steep.

First: Trimix was 500/300/100 mcg mix. I have done 6 doses.

I got the 500mcg alprostadil level instead of 1000 so I would have some leeway in boosting that amount if the 500 did not work well enough (by adding a 500mcg pellet from Muse).

With just Trimix Gel at that formulation I would say that I was able to get 60-80% hardness and was just at the limit of usefulness. There was no Alprostadil ache from the gel, even tho I do get some ache from plain 500mcg muse and about the same hardness I think.

I also tried boosting the gel with a 500mcg pellet. It did not really boost hardness much more but perhaps made it last longer. I think that happens to a lot of guys when they just increase dose, but others do get harder erections too. Also there was some ache with the boosted gel (1000mcg total), but not as much ache as a straight 1000mcg MUSE pellet.

I haven't ordered it again yet since I don't think it was really worth the 30 bucks a pop (or a little more with the MUSE boost). But i suppose i should see how much I can get paid by insurance -- which I neglected to do so far. Might make it more economical if they will pay. But I have Evil Godless Medco for my prescriptions -- so need I say more? (example: 15 crummy 5 mg cialis a month is all they allocate).

So, can't say it is a big improvement over MUSE, but it has promise if the price comes down a bit.

Also I would say to not be afraid to try the 1000/300/100 formulation if your MUSE experience showed you needed 500 or 1000 levels (but you want less ache).

My Uro PA had never heard of Trimix Gel before I mentioned it but she was enthusiastic about me trying it and wanted me to report back if it worked. Have not done so yet since it was not a stunning success. (but i do have 11 more refills if I care to use them).

If anyone has more to add from their trials with the gel, just add them on here. Other questions welcome too.

jim

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Age 58, 195lbs, 6'4", 57 at DX, PSA Aug2008 7 4 ... June2007 4.7 (BPH + LUTS)
Biopsy Nov2008 1 of 12 cores 5%, Gleason 3+3 - Sona showed size 140+ cc (110 grams post op).
02/03/09 open RRP surgery , Nerve sparing both sides, 1 day in hospital, Day 4 first BM,
Pathology Report: All margins clear - No Invasive spread - no change in Gleason score.
02/18/09 Cath out, passed a 1cm oblong STONE within hours.
03/06/09 Started Levitra@20mg / Viagra@100mg / (04/01) Cialis@20mg -- no real effect (thru 11/2009).
04/01/09, 07/07/09, 10/01/09 PSA <0.1 - Stone Was Oxalate stone -- X-ray no stones.
08/09 - started MUSE@1000mcg ... pump&plump - success(80-90%) (alpro ache).
09/09 @500mcg +pump&plump + 2 advil - success(80-90%) - (less Alpro ache).
10/09 TrimixGel (500/300/100mcg): 1st:60%, 2nd:(pump&plump) 60%, 3rd(added 500mcg muse):70-80% -- (no Alpro aches!) but none @ useful hardness!

Post Edited (JimStars) : 12/25/2009 3:07:38 PM (GMT-7)

Add an adjustable cock ring to the Trimix and you should have a usable erection!
Paul

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www.franktalk.org ED website for PCa guys

46 at Diagnosis.
Father died of Pca 4/07 at 86.
10/07 PSA 5.06 (Biopsy 11/07 1 of 12 with 8% involvment) (1mm)
Da Vinci surgery Jan 5, '08 at Mt. Sinai Hosp. NYC www.roboticoncology.com
Saved both nerve bundles.
Path Report: Stage T2cNxMx
-Gleason (3+3)6
Pad free on March 14 - (10 weeks.) Never a problem since.
ED - at one year, ED is fine with viagra.
Two year PSA - undetectable!

My Dr. told me that if the MUSE did not work then the Tri-mix would not work. Do you agree with that statement? Heck the MUSE cast $200 my insurance does not pay for eny ED meds.

JEFF T

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Jeff,

I would probably agree that Trimix Gel will work as good (or not) as MUSE (but perhaps you could tolerate the 1000/300/100 gel better than 1000 mcg MUSE ? (plus it has the extra stuff in the formula for a bit more boost too).

That is a LOT of $$$$ (200) for crummy old MUSE, With insurance I get 6 500 mcg MUSE for about (updated cost $45) -- or 4 at 1000mcg ($35).

Paul,

Yeah I have tried with a ring. Is OK that way, but it introduces the SWIVEL JOINT back -- somewhat like the VED does -- which I want to get away from -- hence using the Gel or MUSE.

Other things:

One thing I noticed about MUSE or Gel is if I pump up in addition to using those, all goes pretty well until near peak hardness when you can get a real ache (like alpro ache). But when you back off the vacuum a bit it subsides, more pump, comes back etc. What this tells me is that the better the Alprostadil works in getting you hard (successful), the more you are gonna ache.

Last night I did try a 500 mcg MUSE (+ 20mg Levitra 1 hr before). That did pretty well .. fairly hard for an hour or two and not much ache. Also I had one of those rings-with-beads-inside and added it just below the head of penis (not at base). That kind of helped I think. For one thing it prevents any leakage/dripping. Might try that again. Since it has been about a month since I used MUSE last, maybe I have progressed a little bit so it works better.

More experimenting is needed!

jim

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Age 58, 195lbs, 6'4", 57 at DX, PSA Aug2008 7 4 ... June2007 4.7 (BPH + LUTS)
Biopsy Nov2008 1 of 12 cores 5%, Gleason 3+3 - Sona showed size 140+ cc (110 grams post op).
02/03/09 open RRP surgery , Nerve sparing both sides, 1 day in hospital, Day 4 first BM,
Pathology Report: All margins clear - No Invasive spread - no change in Gleason score.
02/18/09 Cath out, passed a 1cm oblong STONE within hours.
03/06/09 Started Levitra@20mg / Viagra@100mg / (04/01) Cialis@20mg -- no real effect (thru 11/2009).
04/01/09, 07/07/09, 10/01/09 PSA <0.1 - Stone Was Oxalate stone -- X-ray no stones.
08/09 - started MUSE@1000mcg ... pump&plump - success(80-90%) (alpro ache).
09/09 @500mcg +pump&plump + 2 advil - success(80-90%) - (less Alpro ache).
10/09 TrimixGel (500/300/100mcg): 1st:60%, 2nd:(pump&plump) 60%, 3rd(added 500mcg muse):70-80% -- (no Alpro aches!) but none @ useful hardness!

Post Edited (JimStars) : 12/26/2009 5:58:04 PM (GMT-7)

Jim

Thanks for the reply. I might just have to try again with this MUSE. After all I still have 4 left no reason to pitch them yet!

JEFF T

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Follow-up with TRIMIX GEL -- 1000/300/100 mcg formulation:
First Squirt was without any other helpers ... no Vasoflo ... No Cialis ... (but I did pump before) but without rings.
I would say it got to 80-90% within 20 minutes -- but just barely at usable level even with vigorous stimulations and manipulations.
Was using the ring-with-beads-in-it just below the glans, as i have mentioned before to keep gel in place etc.
Popped a Cialis later on and it might have boosted things -- especially leading into nocturnals.

Overall -- Not a ringing success yet, but that might just be me.

Other observations: absolutely no Alpro ache -- even with the 1000mcg level of alprostadil -- good!
Tumescence lasted for at least 2-3 hours -- although not very usable at later times -- but nice to have around. (was with Cialis tho).
Will try again next time taking the Cialis an hour beforehand and see how that goes.

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Age 58, 57 at DX, PSA Aug2008 7 4 ... June2007 4.7 (BPH + LUTS)
11/2008 Biopsy: 1 of 12 cores 5%, Gleason 3+3 - Sona showed size 140+ cc (110 grams post op).
02/03/09 open RRP surgery , Nerve sparing both sides, 1 day in hospital, Day 4 first BM,
Pathology Report: All margins clear - No Invasive spread - no change in Gleason score.
02/18/09 Cath out, passed a 1cm oblong STONE within hours.
03/06/09 Started Levitra@20mg / Viagra@100mg / (04/01) Cialis@20mg -- no real effect (thru 01/2010).
04/01/09, 07/07/09, 10/01/09, 01/15/10 PSA <0.1
08/09 MUSE@1000mcg +pump&plump - (80-90%) (alpro ache).
09/09 MUSE@500mcg +pump&plump + 2 advil - (80-90%) - (less Alpro ache).
10/09 TrimixGel@(500/300/100mcg): 1st:60%, 2nd:(pump&plump) 60%, 3rd(added 500mcg muse):70-80% --
12/09 MUSE@500mcg+Cialis@20 working well (>90%) and useful erection.
02/10 TrimixGel@1000/300/100mcg - first squirt -- 80-90% - just barely @ useful level. Needs Cialis I think.

Jim, your report sounds like what I have read on the GEL. I have no first hand experience, but read that the GEL was not very effective, perhaps in the 20% range.

Good luck in your trials.

David in SC

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Age: 57, 56 dx, PSA: 7/07 5.8, 7/08 12.3, 9/08 14.5, 10/08 16.3
3rd Biopsy: 9/08 - 7/7 Positive, 40-90% Cancer, Gleason 4+3
Open RP: 11/08, Rht nerves saved, 4 days in hospt, on catheters for 63 days, 5th one out 1/09
Path Rpt: Gleason 3+4, pT2c, 42g, 20% cancer, 1 pos margin

Jeff

I would disagree with your doctor about MUSE and Trimix. MUSE never did much for me but both Caverject and Trimix always worked great. My Urologist said that he hardly prescribed MUSE as his patient's experience wasn't very good.

I switched from Caverject because of the Alprostadil pain.

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Age 60, PSA 2007 4.1, PSA 2008 10.0

hb: I guess I did not make my post clear to you. The Dr said that if the MUSE did not work then Tri-Mix Gel would probably not work either. I have sence got on the needle Caverject works GREAT. I am lucky at this point hot having the Alpro pain. My only complaint at this point is Caverject os SOOOO Expensive. Insurance does not cover the cost.

Jeff T

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Jeff T

Yes, I would agree that if MUSE doesn't work, Trimix Gel probably won't either.

 

New update on Trimix Gel use: Basic Formulation still 1000mcg/300mg/100mg. But I boosted it with a 500 mcg MUSE suppository as well since the last time the regular Gel only only got to around 80%.

With the boost (and no added plumping or rings or anything -- just a 20 mg Levitra -- but I doubt that contributed much since drugs don't do much by themselves),
was able to get a good 100% hard erection after about 10-15 minutes lasting for at least 30 minutes (and maybe workable even after that).

The added alprostadil did tend to ache a bit after an hour --but mostly only if standing up -- but not too bad.

American Pharmacy can be custom blend the gel formula for the same $$$ as the 1000/300/100 version) so I may ask my Uro for such a prescription. I still have one more Gel Shot left so will try again with same MUSE boost just to make sure it is always effective.

So it looks like More is Better for this gel method. And kind of nice that you can modify it on-the-fly if you have MUSE handy.

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Age 59, 57 at DX, PSA Aug2008 7 4 ... June2007 4.7 (BPH + LUTS)
11/2008 Biopsy: 1 of 12 cores 5%, Gleason 3+3 - Sona showed size 140+ cc (110 grams post op).
02/03/09 open RRP surgery ,Nerve sparing, 1 day in hospital.
02/18/09 Cath out -- passed 1 cm oblong bladder stone (not kidney!).
Pathology Report: All margins clear - No Invasive spread - no change in Gleason score.
03/06/09 Started Levitra@20mg / Viagra@100mg / (04/01) Cialis@20mg -- (some tumescence 02-03/2010).
04/01/09, 07/07/09, 10/01/09, 01/15/10 PSA <0.1
08/09-09/09,02-03/10 MUSE@1000mcg (very little ache ) 80-90%
10/09-11/09 TrimixGel@(500/300/100mcg): 60,70,80%,
02/10-03/10 TrimixGel@1000/300/100mcg - 80-90% - (with cialis) - just @ usefulness.