Imipramine for incontinence?

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CharlieTuneA
Regular Member


Date Joined Aug 2009
Total Posts : 37
   Posted 2/4/2010 3:28 PM (GMT -6)   
Hello friends,
 
I haven't been logged in for a while, as I've been just chugging along, trying to deal with things like incontinence and ED on my own, with little success.
 
I have been reading posts almost daily, and am heartened by the support, care and camaraderie that I feel is evident from everyone on the forum.
 
To update:
 
Good news - that the fistula (remember that?) seems to have healed. I'm back to eating regular foods, and am catheter-free - all without the dreaded penis farts I was having.
 
More good news - my last PSA came back 0.03 - so beers are on me, everybody!
 
Not so good news - I'm still dealing with incontinence and pee pads. I go through about three heavy pads daily. Sometimes I feel like I can hold it, other times I feel like Old Faithful - quite a gusher.
 
As far as ED, well, I'm not going to worry too much about it until the urinary control comes back. Thank goodness my wife is understanding and patient.
 
Today I called my uro's office and let them know that it's been about 8 months since DaVinci, and I'm still not dry. They have prescribed imipramine for me, which is an antidepressant, and is also used in pediatrics for bedwetting. Has anyone here ever used this drug for continence? How did it work? Were there any side effects? How long were you on it?, etc.
 
Once again, this board is on my daily "must read" web sites. Thanks to all for the continuous support.
 
-Charlie

Age at diagnosis 59, PSA 1.4
Biopsy 12/08 12 cores, 6 positive
Gleason 3+3=6
CAT scan negative.

DaVinci surgery 6/16/09
After 10 days, cystogram revealed fistula
Catheter Removed 7/17/09
Fistula still evident week of 8/24
PSA 0.03
Catheter Reinserted 8/28/09
2nd catheter removed 9/28/09
 
Still minor evidence of fistula 10/21/09
Doctor recommends close monitoring, continuation of low residue diet, possible temporary colostomy if resurfaces.

Continence is a future goal. Progress slow.


60Michael
Veteran Member


Date Joined Jan 2009
Total Posts : 1824
   Posted 2/4/2010 4:12 PM (GMT -6)   
Great news on many fronts Charlie, including the PSA. Wise on your part not to worry about the ED at this point. You have good support at home as well. Never have used Imipramine but it is often used for children with bed wetting problems. Keep us posted and hope that you see continued improvement.
Michael
Dx with PCA 12/08 2 out of 12 cores positive 4.5 psa
59 yo when diagnosed
Robotic surgery 5/09 Atlanta, Ga
Catheter out after 10 days
Gleason upgraded to 3+5, volume less than 10%
Margin slightly involved
2 pads per day, 1 depends but getting better,
8/5 1 depend at night only, now none
 started ED tx 7/17, slow go
Post op dx of neuropathy
3 months psa.01, 6 month psa.4, 6 1/2 month psa.5
Starting IMRT on 1/18/10
Great family and friends
Michael


Purgatory
Elite Member


Date Joined Oct 2008
Total Posts : 24306
   Posted 2/4/2010 4:32 PM (GMT -6)   
Good to hear from you Charlie, glad the fistula and catheter issues ended for you. Good luck as you continue to fight the incontinence front.
Age: 57, 56 dx, PSA: 7/07 5.8, 7/08 12.3, 9/08 14.5, 10/08 16.3
3rd Biopsy: 9/08 - 7/7 Positive, 40-90% Cancer, Gleason 4+3
Open RP: 11/08, Rht nerves saved, 4 days in hospt, on catheters for 63 days, 5th one out 1/09
Path Rpt: Gleason 3+4, pT2c, 42g, 20% cancer, 1 pos margin
Incontinence:  1 Month     ED:  Non issue at any point post surgery
Post Surgery  PSA: 2/09 .05,5/09 .1, 6/09 .11. 8/09 .16
Post SRT PSA: 1/10 .12
Latest: 7/9 met 2 rad. oncl, 7/9 cath #6 - blockage, 8/9 2nd corr surgery, 8/9 cath #7 out 38 days, 9/9 - met 3rd rad. oncl., mapped  9/9, 10/1 - 3rd corr. surgery - SP cath/hard dialation, 10/5 - 11/27 IMRT SRT 39 sess/72 gys ,cath #8 33 days, Cath #9 35 days, 12/7 - Cath #10 43 days, 1/10 - Corrective Surgery #4, and Caths #11 and #12 in at the same time


tallguy
Regular Member


Date Joined Oct 2009
Total Posts : 399
   Posted 2/4/2010 6:28 PM (GMT -6)   
I tried imipramine and got headaches and constipation and it was no help with incontinence. Same thing with Detrol also an antidepressant. If I remember correctly these are more effective for people with bladder spasms.
 
I have continued using Cunningham clamp to control incontinence until yesterday when I had Virtue Male Sling surgery. See the message thread I started this morning called Coloplast Male Sling.
 
Good news for your PSA and you will also solve the incontinence. It is tough but you do learn to deal with it and you will choose the solution that is right for you. I have had the same thing with ED and may tackle that in a few months after putting the leaking problem behind me. There is a wealth of information on this forum even some of the older threads. Read them all that pertain to you and you will learn a lot. You also may want to check out cancer survivors network.
64  year old male in excellent physical condition.
PSA jumped  3 to 8 in one year
pt2b NO Mx with a Gleason score 3+3=6.
DaVinci RP,  7/23/08. Tumor type: Acinar
size 5.5 cm x 5.7 cm weight: 77 gm.
Largest tumor nodule: 1.3 cm. All margins negative.
Incontinence & ED. Dry nights , no control during day.
Imipremine and detrol, Phy ther. and kegals no help.
FUDS and cystourethroscopy testing 10/09.
Rec. for sling surgery. Dr. does mostly InVance.
Researched and decided on either AdVance or Virtue.
Surgery scheduled for 2/3/09.


James C.
Veteran Member


Date Joined Aug 2007
Total Posts : 4453
   Posted 2/4/2010 6:29 PM (GMT -6)   
Charlie, glad you checked back with us for an update. Glad you openings are closed and your closings are open, whatever applies..... smilewinkgrin
James C. Age 62
Co-Moderator- Prostate Cancer Forum
4/07 PSA 7.6, referred to Urologist, recheck 6.7
7/07 Biopsy: 3 of 16 PCa, 5% involved, left lobe, GS 3/3=6
9/07 Nerve sparing open RRP 110gms.- Path Report: GS 3+3=6 Stg. pT2c, 110gms, margins clear
24 mts: PSA's: .04 each test since surgery, ED Continues-Bimix .3ml PRN or Trimix .15ml PRN


CharlieTuneA
Regular Member


Date Joined Aug 2009
Total Posts : 37
   Posted 2/5/2010 8:56 AM (GMT -6)   
Thanks for the kind replies, guys. I'll give the imipramine a try, although I have my doubts about its effectiveness. I know that there are a lot of potential remedies out there, and I know that given my history, my uro wants to approach each step cautiously.

This whole ordeal has been depressing. I miss simple things like wearing boxers, using the fly in my shorts to pee into a urinal, waking up with wood, etc. I guess I'm still grieving my lost little walnut.

Patience is a virtue, someone said.

-Charlie
Age at diagnosis 59, PSA 1.4
Biopsy 12/08 12 cores, 6 positive
Gleason 3+3=6
CAT scan negative.

DaVinci surgery 6/16/09
After 10 days, cystogram revealed fistula
Catheter Removed 7/17/09
Fistula still evident week of 8/24
PSA 0.03
Catheter Reinserted 8/28/09
2nd catheter removed 9/28/09
 
Continence is a future goal. Progress slow.


Redman55
Regular Member


Date Joined Jan 2010
Total Posts : 87
   Posted 2/5/2010 10:07 AM (GMT -6)   
Charlie, keep the faith. Incontinence will improve, and with all of this, the more effort you put into each issue, the better your results. Incontinence for me has really improved with me now 3 months out, but there are times when I feel I haven't made progress. If you care, go after the ed issue with the 3 "P"'s and you'll get there. Most uro's are fairly passive, and if you don't take the initiative, then neither will they. Fortunately for me, my uro also had prostate cancer so he can relate directly when I went after aggressive ed therapy, and he didn't hesitate to get me on the right tract. I now use ed pills, vac pump, and trimix, and just got back into the game. This forum is fabulous and has tons of information for you. Leverage it, and watch what happens!
Age 54
PSA 8/2009 5.6 Gleason 8
DaVinci surgery 11/2009
Pathology - totally contained in margins -one bundle spared
PSA now undetectable at < .05
Continance: Night and morning fine and improving
Doing 3 P's and now using trimix


Worried Guy
Veteran Member


Date Joined Jul 2009
Total Posts : 3257
   Posted 2/5/2010 4:10 PM (GMT -6)   
I was given Vesicare 10 mg but it did nothing except make me consitipated.
http://www.vesicare.com/
When I looked it up all the patients on the web site were women. I don't know if it is specifically designed for females- (I might as well be, now that Willie turned into a ***oris.)
Please let me know if the Imipramine works for you. I'm right behind you.
Jeff
DX Age 56. First routine PSA test on April 8, 09: 17.8. Start 2 weeks of Cipro to rule out protatitis. May '09 PSA: 22.6, 3 weeks later: PSA: 23.2.
Biopsy 6/10/09: 7/12 scores positive, 20%-70%, Gleason 6=3+3. Bone and C/T scans neg.
RP DaVinci -7/21/2009 @ Univ of Roch Medical Center
Left nerve gone, right partial spared.
Catheter removed - 7/31/2009 Pathology report received:
Gleason 3+4=7, Tumor size: 2.5 x 1.8 cm, location: both lobes and apex.
Extraprostatic extension present; Perineural invasion: present, extensive.
No Malignancy in Seminal Vesicle, vasa deferentia, lymph nodes 0/13
Prostate mass 56 grams. Pathologic Stage: pT3aN0MX
Post Surgery Status:
Potency - 12/11 5 months, Still no activity, zip. Using pump daily since 11/11. No effect with 20 mg of Cialis or 100 mg of Viagra. Shots, See Uro 1/22/10 Trimix unsuccessful.
Incontinence - 8/20 4 full pads per day
.. 9/7 3-4 full pads per day (Try cutting down on fluids. Bad idea. I know.)
11/14 4 months: Still 3 pads per day. 420ml/day, 91 um leak.
12/11 5 months: Still 3 pads per day. 400-450ml/day
1/11/10 6 months: Still 3 pads but leak is now 320 ml (5 day avg.)
Post Surgery PSA - 9/3 6 weeks - 0.05; 10/13 3 months - 0.04, 1/14 6 months - 0.05.


CharlieTuneA
Regular Member


Date Joined Aug 2009
Total Posts : 37
   Posted 2/5/2010 4:21 PM (GMT -6)   
Hi all,

I know it's way too early, but after about a day on imipramine, I do notice an improvement. Not total dryness, mind you, but an improvement for sure.

I'll keep everyone posted.

Hey, Worried Guy, you're from Rochester, right? What part of town do you inhabit? I'm from Brighton, and work in Henrietta. Maybe we can get together sometime for a cup of, um, decaf.

-Charlie
Age at diagnosis 59, PSA 1.4
Biopsy 12/08 12 cores, 6 positive
Gleason 3+3=6
CAT scan negative.

DaVinci surgery 6/16/09
After 10 days, cystogram revealed fistula
Catheter Removed 7/17/09
Fistula still evident week of 8/24
PSA 0.03
Catheter Reinserted 8/28/09
2nd catheter removed 9/28/09
 
Continence is a future goal. Progress slow.


Worried Guy
Veteran Member


Date Joined Jul 2009
Total Posts : 3257
   Posted 2/5/2010 5:09 PM (GMT -6)   
Hey Charlie
I live on the NW side of the city. The rural side. The side with wells, wood burners, septic systems and guns. Did you see the notice for the GFMPH meeting at my place last Sept ?

Sure we can meet up Just a small caveat, I haven't told anyone at work about my situation and prefer not to, so if I know you, I'd have to kill you. I'm sure you understand. Nothing personal. ;-)
You can email me offline. It would be fun to swap info - and incontinence drugs.

Jeff
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