dosage for trimix

I am going to start with trimix instead of Prostaglandin soon--I had lots of issues with burning and soreness--and my doc differs greatly in advice about administration compared with the pharmacist!

Before I go back to him on this, whatkinds of dosing do you fellows who use trimix have the best result with?

I started with Trimix #1 at 0.08 ml. with little to no effect. I gradually increased the dose to .20 ml and that seems to be working.
Everyone is different.
Jeff

---

Married 34 years, DX Age 56. First routine PSA test on April 8, 09: 17.8. Start 2 weeks of Cipro to rule out protatitis. May '09 PSA: 22.6, 3 weeks later: PSA: 23.2.
Biopsy 6/10/09: 7/12 scores positive, 20%-70%, Gleason 6=3+3. Bone and C/T scans neg.
RP DaVinci -7/21/2009 @ Univ of Roch Medical Center
Left nerve gone, right partial spared.
Catheter removed - 7/31/2009 Pathology report received:
Gleason 3+4=7, Tumor size: 2.5 x 1.8 cm, location: both lobes and apex.
Extraprostatic extension present; Perineural invasion: present, extensive.
No Malignancy in Seminal Vesicle, vasa deferentia, lymph nodes 0/13
Prostate mass 56 grams. Pathologic Stage: pT3aN0MX
Post Surgery Status:
Potency - 12/11 5 months, Still no activity, zip. Using pump daily since 11/11. No effect with 20 mg of Cialis or 100 mg of Viagra. Shots next See Uro 1/22/10 Trimix #1. Try 0.08- 25%, 0.12-25%, 2/26/10 try 0.16 First Success! 90%.
Incontinence - 8/20 4 full pads per day
.. 9/7 3-4 full pads per day (Try cutting down on fluids. Bad idea. I know.)
12/11 5 months: Still 3 pads per day. 400-450ml/day
2/26/10 7 months: Still 3 pads but leak is now 320 ml (5 day avg.)
Post Surgery PSA - 9/3 6 weeks - 0.05; 10/13 3 months - 0.04, 1/14 6 months - 0.05.

Each is different, but I seem to be on the high side. I started with .10cc/10 units, and ended up at .20cc/20 units. By comparison, it takes .35c/35units Bimix for the same results. My Trimix is 30/1/20mcg. What's yours?

---

James C. Age 62
Co-Moderator- Prostate Cancer Forum
Gonna Make Myself A Better Man: www.youtube.com/watch?v=a6cX61oNsRQ&feature=channel
4/07 PSA 7.6, referred to Urologist, recheck 6.7
7/07 Biopsy: 3 of 16 PCa, 5% involved, left lobe, GS 3/3=6
9/07 Nerve sparing open RRP 110gms.- Path Report: GS 3+3=6 Stg. pT2c, 110gms, margins clear
32 mts: PSA's: .04 each test since surgery, ED Continues-Bimix .3ml PRN or Trimix .15ml PRN

I agree with James .... everyone I have talked to uses different amounts.  My Dr. started me at 0.1 units ... that was way too much.  Settled in at 0.035 units (boy is that hard to read on the syringe ... really tests the bifocals!).  Trimix at 30/1/10 (Papav/Phen/Alp).

I started at .1 but it didn't work. I'm now at .25 and that works every time. I'm going to reduce it to .2 and see if it works.

---

Age: 67 at Dx on 12/30/08
PSA 9/05 1.15; 8/06 1.45; 12/07 2.41; 8/08 3.9; 11/08 3.5 free PSA 11%
2 cores out of 12 were positive Gleason (4+4) and (4+5)
Negative CT scan and bone scan done on 1/16
Robotic surgery performed 2/9/09 Dr Fagin, Austin TX
Pathology report:
Prostate weighed 57 grams size:5.2 x 5.0 x 4.9 cm
Posterior lateral lesions measuring 1.5 x 1.4 x 1.0 cm showing focal capsular penetration over a distance of 3mm in circumference.
Prostatic adenocarciroma accounts for approx. 10-20% of the hemisphere.
Gleason 4+4
both nerve bundles removed,
pT3a Nx Mx, Negative margins
seminal vesicles clean, lymph nodes: not dissected
continent after 4 months
8 weeks PSA test 4/7/09 result <0.1
5 months PSA test 7/9/09 result <0.1
8 months PSA test 10/9/09 result <0.1
11.5 months test 1/21/10 result 0.004

My Trimix is 16.7/0.56/.0056 PAP/PHEN/ALP.
Jeff

Hi Boss,

Its far more complicated that just how much medication should I put in the syringe

1st as a starting point, your dr should tell you how much to begin with and what increments to increase by if you see no results with the dosage he prescribed

2nd, the process of injecting has a lot to do with the success of the injection

Simply injecting and hoping you get an erection is going to result in no erection, zip, nada. You need to get yourself ready and give the medication a chance to be absorbed into the penis and not get flushed out via blood flow.

There are dozens of excellent posts that describe the process before and after injecting the Trimix. Follow these and you will use a lot less Trimix and enjoy a near perfect if not perfect success rate

---

Stats:
Age: 52, PSA (2008)=1.9
Biopsy on 01/09/09, Gleason Score = 3+3
One (1) out of twelve (12) cores was positive, plus external nodule found
Surgery (Da Vinci, robotic prostatectomy): 4/7/09
Post Op Path 3+3
Removed Catheter: 04/19/09
100% bladder control - Pad free 7/09
PSA 7/09 undetectable, <0.01 - 3 months post-op
PSA 1/10 undetectable, <0.01 - 9 months post-op
Trimix provides 100% erectile function