Lupron and sleep

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kbota
Regular Member


Date Joined Aug 2010
Total Posts : 472
   Posted 10/20/2010 7:52 PM (GMT -6)   
I had my first lupron injection last Thursday, Oct 14. Since then, I have been unable to go to sleep easily. (I have had occasional difficulty staying asleep for the past several years, waking up after just a couple of hours.) Since the lupron, I cannot even get to sleep without taking something such as benadryl+tylenol+red wine. Another interesting thing is that even though I know I'm not getting as much sleep as I should, I'm not tired during the day. I feel very energized all day long. (and it seems half the night as well.)

I was wondering if this is a common side effect of lupron that others may have experienced, or, possibly I have some lupron anxiety going on. (Most of you know how much I agonized over that decision for the last three months, since I posted a jillion questions about it...lol)

Anyway, I wanted to toss this out on the forum to see if anyone else has had a similar experience.

Thanks guys, I appreciate you fellows. You guys make a tremendous difference in the lives of people you touch....and you touch more lives than you know of.

k
Age 57 at Dx
5/09 PSA 2.26
6/2010 PSA 3.07 FPSA 18% DRE +
6/2010 Bipsy, 7 of 12+, >60%, 4+5=9
7/21/2010 - RRP
Nodes neg,Ves neg
tumor in capsule, still 4+5=9
pni extensive
8/5, 2010 cath out
9/3, 2010 PSA - 0.04 whew!
9/3/2010, I'm 99% continent - only stress incontinence
10/14/10, PSA still 0.04, and lupron #1, 99.9% continent
Total ED, 3 caverject failed, pump sux

F8
Veteran Member


Date Joined Feb 2010
Total Posts : 3100
   Posted 10/20/2010 8:06 PM (GMT -6)   
K -- i had that problem initially (i think) but it's not a problem now.  i do have very vivid dreams.  i also take 10 mg of ambien every night so who know what's doing what anymore cool ?
 
for me it seems like the side effects of a 3-month shot start winding down slightly at about two months.  but also take that with a grain a salt because i underwent BT and IGRT while on lupron.
 
ed
 
 
age: 55
PSA on 12/09: 6.8
no symptoms, no prostate enlargement
12/12 cores positive....gleason 3+4 = 7
HT, BT and IGRT
received 3rd and last lupron shot 9/14/10

livinadream
Veteran Member


Date Joined Apr 2008
Total Posts : 1382
   Posted 10/20/2010 8:10 PM (GMT -6)   
I had the same issue and was prescribed ambien. It did make me sleep great but man is that a wicked sleep med. My family told me I would get up at night watch TV send emails and I never remembered a thing. I stayed on sleep meds until I was off Lupron.

peace to you
Dale
My PSA at diagnosis was 16.3
age 47 (current)

http://www.caringbridge.org/visit/dalechildress

My gleason score from prostate was 4+5=9 and from the lymph nodes (3 positive) was 4+4=8
I had 44 IMRT's
I was on Lupron, Casodex, and Avodart for two years with my last shot March 2009. I am currently (7-22-2010) not on any medication.
My Oncology hospital is The Cancer Treatment Center of America in Zion IL
PSA July of 2007 was 16.4
PSA May of 2008 was.11
PSA July 24th, 2008 is 0.04
PSA Dec 16th, 2008 is .016
PSA Mar 30th, 2009 is .02
PSA July 28th 2009 is .01
PSA OCt 15th 2009 is .11
PSA Jan 15th 2010 is .13
PSA April 16th of 2010 is .16
PSA July 22nd of 2010 is .71
Testosterone keeps rising, the current number is 156, up from 57 in May

T level dropped to 37 Mar 30th, 2009
cancer in 4 of 6 cores
92%
80%
37%
28%

F8
Veteran Member


Date Joined Feb 2010
Total Posts : 3100
   Posted 10/20/2010 8:19 PM (GMT -6)   

Dale -- i've read about sleep walking with ambien.  i've never done that but i often forget the last half hour or so before i go to bed.  how long were you on ambien.....did you have trouble getting off the drug?

thanx,

ed


age: 55
PSA on 12/09: 6.8
no symptoms, no prostate enlargement
12/12 cores positive....gleason 3+4 = 7
HT, BT and IGRT
received 3rd and last lupron shot 9/14/10

Don K.
Regular Member


Date Joined Jan 2010
Total Posts : 69
   Posted 10/20/2010 8:45 PM (GMT -6)   
I never had a sleep problem on Lupron. Outside of total loss of sexual desire & function, many hot flashes & depression, Lupron was just lovely!
 
Don K.

kbota
Regular Member


Date Joined Aug 2010
Total Posts : 472
   Posted 10/20/2010 9:10 PM (GMT -6)   
That good huh Don?

At least I know what I have to look forward to for the next 3 years. How long did it take for all those lovely side effects to kick in?

I'm a week out today, and so far...only sleep is an issue. I wonder if the sleep thing is a result of the testosterone flare? If indeed that is right, then I would assume that after the T levels drop, I'll be sleeping all the time. hmmmm

k
Age 57 at Dx
5/09 PSA 2.26
6/2010 PSA 3.07 FPSA 18% DRE +
6/2010 Bipsy, 7 of 12+, >60%, 4+5=9
7/21/2010 - RRP
Nodes neg,Ves neg
tumor in capsule, still 4+5=9
pni extensive
8/5, 2010 cath out
9/3, 2010 PSA - 0.04 whew!
9/3/2010, I'm 99% continent - only stress incontinence
10/14/10, PSA still 0.04, and lupron #1, 99.9% continent
Total ED, 3 caverject failed, pump sux

F8
Veteran Member


Date Joined Feb 2010
Total Posts : 3100
   Posted 10/20/2010 9:23 PM (GMT -6)   
K -- being active really helps with the side effects, which you should start feeling in an other week or so.  i take 20 mg of celexa for side effects and i only get pretty minor hot flashes and no depression.  i have gained 20 lbs tho and bloating and gas are problems but really not that terrible..
 
ed
 
 
age: 55
PSA on 12/09: 6.8
no symptoms, no prostate enlargement
12/12 cores positive....gleason 3+4 = 7
HT, BT and IGRT
received 3rd and last lupron shot 9/14/10

Don K.
Regular Member


Date Joined Jan 2010
Total Posts : 69
   Posted 10/21/2010 12:17 AM (GMT -6)   
Kbota:
F8 has it nailed -about three weeks
 
The worst thing for me was the total loss of libido. I could (can) hardly believe that suddenly, you don't even WANT sex anymore. Really weird.
 
Now I understand why the kings of old had eunics (sp) in their harems. Those dudes not only could not get it up, but they didn't even want to.
 
The good thing though is that we are talking about chemical castration here and not physical removal of the testicles. So at some point after stopping the Luron a person will regain his normal testosterone level and related libido.
 
So, better to be walking around with non-functional sexual equipment than be buried with a nice erection.
 
"The grave, I'm told is a fine and quiet place,
but none there, I think, do embrace."
-Unkn
 
Don K.

Tony Crispino
Veteran Member


Date Joined Dec 2006
Total Posts : 7468
   Posted 10/21/2010 1:50 AM (GMT -6)   
kbota,
I did have multiple side effects with the hormone therapy, including sleep deprivation, but I got most of them under control including the sleep issues. I asked for a sleep aid and 15mg of Temazepam nailed it. I received a single prescription of 30 capsules and I took them only occasionally when needed until it expired by time. I did have periodic sleeping deprivation "events" but they were rare. All in all, I'm past that stage of therapy and things are going quite well.

It get's better my friend. Hang in there...

Tony
Disease:
Advanced Prostate Cancer at age 44 (I am 48 now)
pT3b,N0,Mx (original PSA was 19.8) EPE, PM, SVI. Gleason 4+3=7

Treatments:
RALP ~ 2/17/2007 at the City of Hope near Los Angeles.
Adjuvant Radiation Therapy ~ IMRT Completed 8/07
Adjuvant Hormone Therapy ~ 28 months on Casodex and Lupron.

Status:
"I beat up this disease and took its lunch money! I am in remission."
I am currently not being treated, but I do have regular oncology visits.
I am the president of an UsTOO chapter in Las Vegas

Blog : www.caringbridge.org/visit/tonycrispino

Post Edited (TC-LasVegas) : 10/21/2010 1:54:46 AM (GMT-6)


julios
Regular Member


Date Joined Jun 2010
Total Posts : 38
   Posted 10/21/2010 6:51 PM (GMT -6)   
Kbota

Did you say Lupron for 3 years??! I have similar disease, and my med oncologist is suggesting it will be only 6 months. He said recent studies suggest there is no proven benefit to do it longer. He said maybe a year at most. For me. May want to question that.
Age 52

At Diagnosis of PCa, had Gleason 9 and normal PSA

Radical Prostatectomy on July 7th, 2010 by Dr. Fagin using daVinci

25% to 50% nerves spared on left, 100% spared on right.

Continent from day one.

Pathology showed postive margins and extension beyond gland, including seminal vesicals and lymph nodes. Stage upgraded to T3b.

kbota
Regular Member


Date Joined Aug 2010
Total Posts : 472
   Posted 10/21/2010 7:15 PM (GMT -6)   
I did say that Julios, but I left out important facts. My apologies. My uro doc is planning on lupron shots every four months for the next two years, but then it takes another 1 to 1.5 years for the testosterone levels to return...

So my 3 year comment was referring to the total influence period. Had my PCa not been capsule confined, then he was planning on three years.

I do believe that the last few days, I have been under the influence of a testosterone flare. (Today is one week since first lupron injection.) I can't remember "wanting" my wife as much as the last few days....and my energy levels are off the chart....

Until dinner a few minutes ago, I had one meal today, which was a small bowl of breakfast cereal. I've been building a 16' x 32' deck on the back of our new home. It's fairly labor intensive, and I've been going at it almost non stop all day, and only stopped working around 7:00pm when our daughter came for a visit. Now, I'm not complaining at all. I rather enjoy this. I'm just fearful of when the T levels drop like a rock. It may get ugly.

k
Age 57 at Dx
5/09 PSA 2.26
6/2010 PSA 3.07 FPSA 18% DRE +
6/2010 Bipsy, 7 of 12+, >60%, 4+5=9
7/21/2010 - RRP
Nodes neg,Ves neg
tumor in capsule, still 4+5=9
pni extensive
8/5, 2010 cath out
9/3, 2010 PSA - 0.04 whew!
9/3/2010, I'm 99% continent - only stress incontinence
10/14/10, PSA still 0.04, and lupron #1, 99.9% continent
Total ED, 3 caverject failed, pump sux

compiler
Veteran Member


Date Joined Nov 2009
Total Posts : 4929
   Posted 10/21/2010 10:16 PM (GMT -6)   
I've never been on steroids but it sounds just like that (from what I've read), although you are not on steroids...are you?
 
Mel

Sancarlos
Regular Member


Date Joined Feb 2010
Total Posts : 241
   Posted 10/22/2010 3:35 AM (GMT -6)   
I had my first Lupron injection in August 2009 and have been on it since then. From the time I began taking Lupron I had a lot of trouble sleeping. Ambien worked ok but none of the docs would give me more than a two week or month supply of the drug. Then a couple of months ago I was diagnosed with cervical stenosis, which is a narrowing of the spinal cord channel due to degenerative arthritis. In my case the channel has narrowed down to 0.7 mm and an operation is in the near future. However, to combat the muscle spasm that result from pinching of the spinal cord my physician gave me a prescription of a muscle relaxer called Tizanidine, and it is very, very effective at putting me to sleep.

Would also add that a testosterone inhibitor like Lupron has many other side effects that need to be countered, including bone density loss and general physical weakening. In spite of the fact that I exercise quite a bit there is no question but that I have much less strength and endurance than before I began taking Lupron. I am in China right now and just spent a week hiking up and down the steep hills of Huangshan Mountain, also called the Yellow Mountains. I found the activity here this year was much more fatiguing than on a similar trip I made to Huangshan a couple of years ago before I began taking Lupron. Some of this may be fatigue from being two years older but I feel that most of the fatigue is due to the effects of Lupron.

Sancarlos
Age 66, PC diagnosed 7/2009 at age 65
Stage: T2c, Gleason: 9 (4 + 5), 6 of 6 cores positive
Bone, CAT and MIR scans negative

Treatment: brachytherapy (103 palladium), 100 gy, 11/2010 + hormone therapy (Lupron + Casodex) + IMRT on Novalis, 45 gy, 3/2010.

PSA: 7/2009, At time of diagnosis -- 11.9
10/2009 -- 5.0
12/2009 -- 0.56
5/2010 -- 0.15
8/9/2010 -- 0.06

Post Edited (Sancarlos) : 10/22/2010 6:33:11 PM (GMT-6)


erbob
Regular Member


Date Joined Jan 2010
Total Posts : 201
   Posted 10/22/2010 6:29 PM (GMT -6)   
Only received one Lupron shot which was back in February of this year. The sleep that I did lose was due to the hot flashes which appeared during the night. They weren't really too bad but still bad enough to make me wake up sweating.

kbota
Regular Member


Date Joined Aug 2010
Total Posts : 472
   Posted 10/23/2010 4:55 PM (GMT -6)   
compiler said...
I've never been on steroids but it sounds just like that (from what I've read), although you are not on steroids...are you?Mel


Mel, I have also never been on steroids, except for a short dose ten years ago, for a bad sinus infection. And I'm not on steroids now.

I'm not sure what's going on, but I'm paying close attention. I've spent all day today working outside, and loving every minute of it.

Maybe it's just this beautiful weather we've been having. 60 deg in the morning, 80 in the afternoon, with a gentle breeze and low humidity, (for a change) That by itself is worth getting excited about.

Carlos; I'll bet you are having the time of your life in China. I would love to go there someday. Be careful, but enjoy yourself.

k
Age 57 at Dx
5/09 PSA 2.26
6/2010 PSA 3.07 FPSA 18% DRE +
6/2010 Bipsy, 7 of 12+, >60%, 4+5=9
7/21/2010 - RRP
Nodes neg,Ves neg
tumor contained, still 4+5=9
pni ext.
9/3, 2010 PSA - 0.04
9/3/2010, I'm 99% continent
10/14/10, PSA still 0.04, and lupron #1, now 99.9% continent
Total ED, 3 caverject failed, pump sux
10/20/10 OD'd on trimix, after 3hrs, neo synephrine shot

Sancarlos
Regular Member


Date Joined Feb 2010
Total Posts : 241
   Posted 10/24/2010 7:09 PM (GMT -6)   
Kbota,

China is indeed a fascinating place to visit. This is actually my third trip here and I have some local friends who really look after me so in many ways I find it safer than travel in parts of Europe and South America. Anyway this trip is about over as I am heading to Shanghai this afternoon for a return flight to the US tomorrow morning.

I am very grateful that the treatment option for PCa that I chose did not leave me with any side effects that prevent me from exercising and traveling. At this point in time I am about one year out from seeds, and about seven months out from IMRT, and as far as I can determine I have no side effects from either. I do have some side effects from Lupron, but for the most part they are manageable. Loss of libido is about the most irritating part of the HT, but hopefully that will return some time after I go off HT.

Sancarlos
Age 66, PC diagnosed 7/2009 at age 65
Stage: T2c, Gleason: 9 (4 + 5), 6 of 6 cores positive
Bone, CAT and MIR scans negative

Treatment: brachytherapy (103 palladium), 100 gy, 11/2010 + hormone therapy (Lupron + Casodex) + IMRT on Novalis, 45 gy, 3/2010.

PSA: 7/2009, At time of diagnosis -- 11.9
10/2009 -- 5.0
12/2009 -- 0.56
5/2010 -- 0.15
8/9/2010 -- 0.06
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