Doxycycline and other tetracyclines in the treatment of bone metastasis.

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will1
New Member


Date Joined Dec 2010
Total Posts : 15
   Posted 12/22/2010 6:03 PM (GMT -6)   
Folks, I have used doxycycline off and on for years.  Of course you can not use it on a regular basis; I use it about every 3 to 4 months for a weak or two at a time.
 
As some of you know I do the shotgun approach (my invention) to fighting cancer.  I will do about anything that might help, as long as I don't do my body harm.  Works for me.  Still psa under .01 after 16 years, gleason 9, in lymph nodes. Never had a rise in psa.  No brag, just thankful.
 
 
Will
 
P.  S.  Not intended for advice.  I hope I have not broken any rules by posting a research project from Pub Med.
 
Anticancer Drugs. 2003 Nov;14(10):773-8.

Doxycycline and other tetracyclines in the treatment of bone metastasis.
Saikali Z, Singh G.

Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.

Abstract
The tetracycline family includes tetracycline, doxycycline and minocycline, all of which have been used as antibiotics effectively for decades. New uses emerged for these compounds after their effect on mitochondrial function was discovered. Cytostatic and cytotoxic activity of these compounds was shown against cell lines of various tumor origins. In addition, tetracyclines and chemically modified tetracyclines inhibit the activity of several matrix metalloproteinases (MMPs). Given the importance of these enzymes in tumor cell invasion and metastatic ability, the potential use of tetracyclines in cancer therapy needed to be investigated. Col-3, a chemically modified tetracycline, is now the subject of clinical trials in cancer patients. However, the potential of tetracyclines in cancer therapy takes on an added dimension in the bone. MMPs have been shown to be important mediators of metastasis formation in the bone, contributing largely to the morbidity of breast cancer and prostate cancer patients. The natural osteotropism of tetracyclines would allow them to be highly effective in the inhibition of MMPs produced by osteoclasts or tumor cells in the bone. This hypothesis has now been confirmed by experimental evidence showing that doxycycline reduces tumor burden in a mouse model of breast cancer-derived osteolytic bone metastasis. This effect is likely due to a combination of multiple roles of doxycycline, including MMP inhibition and a negative effect on osteoclast differentiation and survival. These encouraging results have now paved the way for an ongoing trial of doxycycline in early combination therapy for breast cancer and prostate cancer patients.

PMID: 14597870 [PubMed - indexed for MEDLINE]


Publication Types, MeSH Terms, SubstancesPublication Types:
Research Support, Non-U.S. Gov't
Review
MeSH Terms:
Animals
Antibiotics, Antineoplastic/pharmacology
Antibiotics, Antineoplastic/therapeutic use
Bone Neoplasms/drug therapy*
Bone Neoplasms/secondary*
Breast Neoplasms/pathology
Cell Line, Tumor
Clinical Trials as Topic
Doxycycline/pharmacology
Doxycycline/therapeutic use*
Female
Humans
Male
Matrix Metalloproteinases/antagonists & inhibitors
Prostatic Neoplasms/pathology
Tetracyclines/pharmacology
Tetracyclines/therapeutic use*
Substances:
Antibiotics, Antineoplastic
Tetracyclines
Doxycycline
Matrix Metalloproteinases
LinkOut - more resourcesFull Text Sources:
Lippincott Williams & Wilkins
Ovid Technologies, Inc.
Swets Information Services
Medical:
Bone Cancer - MedlinePlus Health Information
Molecular Biology Databases:
DOXYCYCLINE - HSDB
Supplemental Content
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Tony Crispino
Veteran Member


Date Joined Dec 2006
Total Posts : 7702
   Posted 12/22/2010 6:54 PM (GMT -6)   
Thanks for the post Will.
I need to take some time and digest everything. But keep 'em coming...

Tony
Disease:
Advanced Prostate Cancer at age 44 (I am 48 now)
pT3b,N0,Mx (original PSA was 19.8) EPE, PM, SVI. Gleason 4+3=7

Treatments:
RALP ~ 2/17/2007 at the City of Hope near Los Angeles.
Adjuvant Radiation Therapy ~ IMRT Completed 8/07
Adjuvant Hormone Therapy ~ 28 months on Casodex and Lupron.

Status:
"I beat up this disease and took its lunch money! I am in remission."
I am currently not being treated, but I do have regular oncology visits.
I am the president of an UsTOO chapter in Las Vegas

Blog : www.caringbridge.org/visit/tonycrispino

142
Forum Moderator


Date Joined Jan 2010
Total Posts : 5921
   Posted 12/22/2010 10:12 PM (GMT -6)   
Interesting. I have taken tetracycline regularly for years (20+), and was found with a Gleason 4+5 post-DaVinci.
 
Did it do nothing, or should I have been dead years ago?

will1
New Member


Date Joined Dec 2010
Total Posts : 15
   Posted 12/23/2010 3:11 PM (GMT -6)   
Interesting point. I hope the professionals will tell us some day.

Will H
Aged, gleason 9, psa prior to surgery 2.3. Took prostate and testies out at Mayo Clinic, Sep 4, 1994. Gleason 9, in lymph nodes. I have been very aggressive in my treatment plan. I have never had a rise in psa, 16 years out. Still less than .01. My twin brother, also gleason 9, passed away 6 years ago with prostate cancer. He was not very aggressive in his treatment plan.

Will H

tarhoosier
Regular Member


Date Joined Mar 2010
Total Posts : 346
   Posted 12/24/2010 9:51 AM (GMT -6)   
Will:
I recall that you had adjuvant orchiectomy all those years ago, which would certainly have been the ne plus ultra of your treatments.

will1
New Member


Date Joined Dec 2010
Total Posts : 15
   Posted 12/24/2010 5:27 PM (GMT -6)   
I believe the best things that I did for my suggess were:

1) Surgery
2) Immediate triple blockade
3) Taking a "shotgun" approach to my treatment plan. In otherwords do about anything, and everything, that !) won"t hurt your body, 2) Has some form of reliabel research behind it.

It worked for me.
Aged, gleason 9, psa prior to surgery 2.3. Took prostate and testies out at Mayo Clinic, Sep 4, 1994. Gleason 9, in lymph nodes. I have been very aggressive in my treatment plan. I have never had a rise in psa, 16 years out. Still less than .01. My twin brother, also gleason 9, passed away 6 years ago with prostate cancer. He was not very aggressive in his treatment plan.

Will H

globalwanderer
New Member


Date Joined Jan 2011
Total Posts : 1
   Posted 1/8/2011 1:19 PM (GMT -6)   
I am posting on behalf of a friend who had prostate cancer (had prostate removed) has been doing the raw food diet etc. but now has bone cancer pretty widespread ( skull etc.) . I read about the Dr. at McMaster U. in 2003 ? and wondered what the outcome of his trial on Tetracycline was ? My friend is willing to do anything ( is juicing etc.) . Is this old drug taken orally or by injection? and where can you get it? Would it have to be prescribed here in Ontario Canada? (If so good luck finding a Dr. who will sign a prescription for it for bone cancer. Possibly my buddy could eat a bunch of chocolate and get acne then get a prescription. (Not likely he is on morphine ) Any assistance or information on this would be greatly appreciated

daveshan
Regular Member


Date Joined Jan 2010
Total Posts : 363
   Posted 1/8/2011 3:30 PM (GMT -6)   
I missed this post when I came up the first go round.

Interesting aside, we have an old Beagle/Basset mix who was diagnosed with highly aggressive cancer in his esophagus in June of '09, the cancer was extending out his ear and was de-bulked twice, he was given less than 6 months at that time. He also has had chronic lung infections and has been on doxycycline most of the last 18 months, his cancer has disappeared and except for ongoing lung issues he's happy and healthy. His Vet' is mystified but happy. I'll have to track down that study, print it out and take it to them.

Thanks for posting this
Dave in Durango CO
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