CRPCa: Targeted Therapies-Individualized Treatment (TheOncologist.com)-weblink

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zufus
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Date Joined Dec 2008
Total Posts : 3129
   Posted 6/21/2011 7:33 AM (GMT -6)   
This is becoming more and more the future on treating PCa,  here is an article on Castration-resistant PCa and targeted therapies and working towards more individualized treatments.  Peyton Rous (1911) discovered SRC (sarcoma) in chickens (no less)
 and later thus the finding the few pathways that effect PCa in various different ways (Nobel Prize in 1966), in this article alot of that information is devulged on the mechanisms and methods to effect PCa on a cellular level. It is very complex, but reading this will give you an idea of what is being researched and the terminology and types of genes and things...that are going to be your buzz words. Certain drugs and therapies are mentioned in this article as to treating specific agents in CRPCa, many of those are in Phase II or III within this article, also. (contracted research: Cougar Biotechnology, Novartis, ImClone.)- fyi
 
You can search other information on cancers and things at this website too. When you go to the weblink (general weblink), Click on March 2011  vol. 16 #3 then find article therein, I think it is the second article mentioned in that issue, click on Castration Resistant PCa.....(yada-yada) as written above.  www.TheOncologist.com    (R. Aggarwal & Chas. Ryan)
 
(gives  a glimpse of the twilight zone of PCa) cool

zufus
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Date Joined Dec 2008
Total Posts : 3129
   Posted 6/21/2011 3:50 PM (GMT -6)   
rolleyes   I cannot wait to hear what a particular patients doc has to say about a supplement or tea or broccoli(more important than knowing about PCa).....I will be sure to write it down and frame it as the end all definitive answers. (LOL) 
 
LOL- it must be like illegal for a patient to take supplements, teas, pomegranite juice, healthy vegetables and fruits....does this stuff mask PCa....looking for abstracts on such or referral to anyone doc whom knows for certain.
 
Bon Appetite
 
 

Post Edited (zufus) : 6/21/2011 3:33:51 PM (GMT-6)


Purgatory
Elite Member


Date Joined Oct 2008
Total Posts : 23871
   Posted 6/21/2011 4:05 PM (GMT -6)   
Why would any "particular" patient ask a doctor about broccoli or tea? If you like broccoli, eat it. If you like to drink tea, quench your thirst. Who on the board is against healthy fruits and vegetables? You are talking in some code of your own. Fruits and vegetables are an important part of the food pyramid, and crucial to any heart healthy diet. Is this part of some new conspiracy of yours?

david in sc
Age: 58, 56 dx, PSA: 7/07 5.8, 10/08 16.3
3rd Biopsy: 9/08 7 of 7 Positive, 40-90%, Gleason 4+3
open RP: 11/08, on catheters for 101 days
Path Rpt: Gleason 3+4, pT2c, 42g, 20% cancer, 1 pos margin
Incont & ED: None
Post Surgery PSA: 2/09 .05,5/09 .1, 6/09 .11. 8/09 .16
Post SRT PSA: 1/10 .12, 4/8 .04, 8/6 .06, 2/11 1.24, 4/11 3.81, 6/11 5.8
Latest: 6 Corr Surgeries to Bladder Neck, SP Catheter since 10/1/9, SRT 39 Sess/72 gy ended 11/09, 21 Catheters, Ileal Conduit Surgery 9/10

Ziggy9
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Date Joined Jul 2008
Total Posts : 891
   Posted 6/21/2011 4:48 PM (GMT -6)   
As someone who has had successful targeted treatment I can't make any sense of that site. They might as well be talking klingon.

Not for a layman.
Diagnosed 11/08/07 - Age: 58 - 3 of 12 @5%
Psa: 2.3 - 3+3=6 - Size: 34g -T-2-A

2/22/08 - 3D Mapping Saturation Biopsy - 1 of 45 @2% - Psa:2.1 - 3+3=6 - 28g after taking Avodart - Catheter for 1 day -Good Candidate for TFT(Targeted Focal Therapy) Cryosurgery(Ice Balls) - Clinical Research Study

4/22/08 - TFT performed at University of Colorado Medical Center - Catheter for 4 days - Slight soreness for 2 weeks but afterward life returns as normal

7/30/08 - Psa: .32
11/10/08 - Psa.62 -
April 2009 12 of 12 Negative Biopsy

2/16/10 12 of 12 Negative Biopsy

zufus
Veteran Member


Date Joined Dec 2008
Total Posts : 3129
   Posted 6/21/2011 4:55 PM (GMT -6)   
Helps us see how simplistic PCa is (LOL). Some of that stuff I am starting to key in on, I did say some...it is not PCa 101 by any stretch. The weblink is good for alot of various researching info, also. My onco-doc loves reading this kind of stuff-LOL.

Ziggy-results look good, got any psa number???

Ziggy9
Veteran Member


Date Joined Jul 2008
Total Posts : 891
   Posted 6/21/2011 5:38 PM (GMT -6)   
zufus said...
Helps us see how simplistic PCa is (LOL). Some of that stuff I am starting to key in on, I did say some...it is not PCa 101 by any stretch. The weblink is good for alot of various researching info, also. My onco-doc loves reading this kind of stuff-LOL.

Ziggy-results look good, got any psa number???


depending on the source they range from the VA 11/2010 =.32 and my Uro 3/2011=.24 , well within acceptable numbers.

I should redo the sig and add them but at times I think I'm gone from this site soon.

Purgatory
Elite Member


Date Joined Oct 2008
Total Posts : 23871
   Posted 6/21/2011 7:08 PM (GMT -6)   
ziggy, either number you listed would be considered excellent post the treatment path you chose.
Age: 58, 56 dx, PSA: 7/07 5.8, 10/08 16.3
3rd Biopsy: 9/08 7 of 7 Positive, 40-90%, Gleason 4+3
open RP: 11/08, on catheters for 101 days
Path Rpt: Gleason 3+4, pT2c, 42g, 20% cancer, 1 pos margin
Incont & ED: None
Post Surgery PSA: 2/09 .05,5/09 .1, 6/09 .11. 8/09 .16
Post SRT PSA: 1/10 .12, 4/8 .04, 8/6 .06, 2/11 1.24, 4/11 3.81, 6/11 5.8
Latest: 6 Corr Surgeries to Bladder Neck, SP Catheter since 10/1/9, SRT 39 Sess/72 gy ended 11/09, 21 Catheters, Ileal Conduit Surgery 9/10
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