I am sure that the trauma of radical surgery impacts the energy level of patients.
Impotence and incontinence are early side effects that impact all of us that have undergone that surgery. Recovering takes time and exercise.
On the other hand, there are reports in the medical literature that the presence of PCa does affect the level of testosterone. This could be related to the fact that prostate cancer cells metabolize testosterone faster than normal prostate cells. In fact, several studies report an increase of testosterone after radical prostate surgery. The effect on reducing testosterone before surgery is more pronounced with more poorly differentiated disease.
"Iversen P, Rasmussen F, Christensen IJ. Serum testosterone as a prognostic factor in patients with advanced prostatic carcinoma. Department of Urology, Rigshospitalet, University of C
openhagen, Denmark.PMID: 7939452. Reported: correlations with symptomatology and other pretreatment parameters
suggest that low serum testosterone merely is a consequence of the advanced
malignancy rather than a causative factor in the pathogenesis of prostatic
The following studies report an increase in testosterone after radical prostatectomy:
1. Imamoto T, Suzuki H, Yano M, Kawamura K, Kamiya N, Araki K, Komiya A, Naya Y,
Shiraishi T, Ichikawa T. Does presence of prostate cancer affect serum
testosterone levels in clinically localized prostate cancer patients? Prostate
Cancer Prostatic Dis. 2009;12(1):78-82. Epub 2008 Jun 3. PubMed PMID: 18521100
Significant increases in serum T and LH levels were seen after RP, compared to preoperative levels in parallel. This study suggests that serum T levels are altered by the presence of PCa, supporting the possibility that PCa may inhibit serum T levels with negative feedback in the hypothalamic-pituitary axis.
2. INFLUENCE OF RADICAL PROSTATECTOMY ON SERUM HORMONE LEVELS
LESLIE R. MILLERa, ALAN W. PARTINa, DANIEL W. CHANa, DEBRA J. BRUZEKa, ADRIAN S. DOBSa, JONATHAN I. EPSTEINa and PATRICK C. WALSH
J Urol. 1998 Aug;160(2):449-53.
Following radical prostatectomy there was a statistically significant increase in serum testosterone, free testosterone, estradiol, LH and FSH (p <0.0001), and statistically significant decrease in serum DHT (p <0.0001). No difference was noted in serum sex hormone binding globulin or prolactin levels.
hormone (FSH), sex hormone binding globulin and prolactin.
These data further suggest that the normal prostate and/or prostate neoplasm could secrete a substance or substances that give negative feedback control to pituitary gonadotropin secretion. Further investigation is warranted to identify this substance or substances.
3. Impact of radical prostatectomy and TURP on the hypothalamic-pituitary-gonadalhormone axis. Madersbacher S, Schatzl G, Bieglmayer C, Reiter WJ, Gassner C, Berger P, Zidek T, Marberger M. Department of Urology, University of Vienna, Vienna, Austria. PMID: 12429318
Patients with Gleason score 2 to 6 PCa had higher testosterone values (4.2 ng/mL) at baseline than did those with Gleason score 7 to 10 PCa (2.2 ng/mL, P < 0.05). Although 12 months after RP no changes in testosterone were observed in the low Gleason score group, the testosterone levels more than doubled in those with high-grade tumors.
I am a prostate cancer survivor since 1992. The views or opinions expressed here are my own and are not endorsed nor supported by any agency or institution. Use your physician for medical advice.
DX at age 58. RP; Orchiectomy; GS (4 + 2); bilateral seminal vesicle invasion; tumor attached to rectal wall; Stage T4; Last PSA July, 0'11: <0.1 www.pcainaz.org