Starting Abiraterone (Zytiga)

New Topic Post Reply Printable Version
[ << Previous Thread | Next Thread >> ]

Raddad
Veteran Member


Date Joined Jul 2011
Total Posts : 1857
   Posted 3/21/2012 4:46 PM (GMT -7)   
Went into the VA Hospital in DC for my monthly Zometa and to get my PSA checked. Quite honestly I expected it to go up and was not disappointed, well heck sure I was but it was what I was expecting.

PSA came in at 149. Spoke with my oncologist who is head of Oncology for the VA facility in DC. I knew from all I've learned here that the next steps were going to be some chemo. I really did not want to go on Docetaxel (taxotere) but would if thats what my Doc said would be for the best. But he said he would prefer I went to Abiraterone. I agreed:)

I'm starting Abiraterone (zytiga) tomorrow - 4 tabs once a day. A single tab is 250 mg.

Will also be taking two Prednisone. One in the morning and one in the evening.

Anyone have any guidance on Abiraterone (zytiga) and Prednisone? Expected side effects? Anything?

On 3 April I go in have blood work to make sure the Zytiga is not hurting liver functions.
Will also have a "trace" PET scan done as they saw something in my right lung. The Pulmonary doctor has started me on a anti-biotic to rule out any infection before actually doing the scan. I asked well what if it is cancer? He said very calmly we will take care of it, but lets not even talk about "what if" until we do the scans. - Ok I'm good with that:)

25 April will be next PSA and Zometa (my monthly) and Eligard (three month). Assuming the PSA stays the same on goes down will continue with the Abiraterone (zytiga).

The date actually fell on 23 April, but I'll just be coming back from GFMPH Cajun style. I told my transfusion nurse about GFMPH and she said "Thats really important! The 25th is fine"

I was a little concerned starting with Abiraterone before Docetaxel (taxotere) could be problematic if the Abiraterone (zytiga) does not work as so many medicines are stipulated for use "after chemo failure". My oncologist said not to worry about that he will make sure I get whatever is needed as soon as it is available

We also spoke about MDV-3100, my Oncologist is looking forward to its approval. once it is approved I'll probably go on that also.

I brought Provenge up - My Doc said Very Expensive, like $100,000 where Zytiga is $6,000 a month. ALSO - Provenge can't be used if the prostate cancer critters have already spread to the bones. I did not argue that with the Doctor but I've not seen anything that says that. Anyone know if Provenge can't be used if the PCa has spread to the bones?

I /will/ beat this thing! Its just a number!

Bud
64 as of April 2012
Gonna Make Myself A Better Man tinyurl.com/28e8qcg
12 Jul 2011 - PSA 1447 (It's just a number! )
Scans showed active prostate cancer widespread in bones
Started HT treatments Casodex, Zoladex and Zometa for bone
Last Casodex - 29 August
31 Oct 11 - PSA 46.6
25 Jan 12 - PSA 75
22 Feb 12 - PSA 99 - Restarted Casodex
22 Mar 12 - PSA 149 - Start Zytiga

nhwife
Veteran Member


Date Joined Mar 2012
Total Posts : 721
   Posted 3/21/2012 6:06 PM (GMT -7)   
Hi Bud,
I answered you in the other thread but just wanted to make sure you do follow the guidelines for taking the medication. The zytiga needs to go into an empty stomach: 2 hours after eating and 1 hour before. My husband has his routine all set.
Again, wish you the best with this!
Hubby, dx 2002, age 50
PSA 6.8 Gleason 7 (4+3)
Surgery Jan 2003
G7pT3c perineural involve., sem. ves., neg. margins
2005 rising PSA
2006 RT, HT
2008 Casodex, Zometa
2011 Ketoconazole, hydrocort.
Rising PSA Dec. 2011 20.2
2012 Zytiga PSA March 2012 14

zufus
Veteran Member


Date Joined Dec 2008
Total Posts : 3141
   Posted 3/21/2012 6:29 PM (GMT -7)   
Good luck to you Raddad, hope it is worthy and wish you decent side effects. You can fill us in on how it works for you, with any drug results vary. I tried contacting the FDA source mentioned on another forum concerning MDV3100 and early access program, but the email didn't help answer that at all and just mentioned to contact them about other possible alternatives, so hurry up and wait. My doc is looking into that one also and I may hear something on it, I wish to try that one when available.

F8
Veteran Member


Date Joined Feb 2010
Total Posts : 3280
   Posted 3/21/2012 6:52 PM (GMT -7)   
Bud -- sorry to hear that.  i really respect your courage.  Zufus -- are you okay?
 
ed
 
 
age: 56
PSA on 12/09: 6.8
gleason 3+4 = 7
HT, BT and IGRT
received 3rd and last lupron shot 9/14/10
2/8/11 PSA <.1, T= 6 ng/dl
6/8/11 PSA .2, T = 540 ng/dl
8/19/11 PSA .3, T = 487 ng/dl
10/5/11 PSA .2, T = 530 ng/dl
3/1/12 PSA .3

WinterSolstice
Regular Member


Date Joined Dec 2011
Total Posts : 65
   Posted 3/21/2012 7:01 PM (GMT -7)   
Raddad,

I am three months into my Abiraterone+Prednisone+Lupron. My liver function and blood work have all been good. My last blood test had my Potassium level falling in the low normal range, so I have started a Potossium supplement just to be on the safe side. My advice is to make sure you have regular blood work, and your doctors are monitoring the results closely.

As far as side effects, I have mild hot flashes which are common for HT. I had spells of very mild nausea early on, but this has subsided. I am not sure if it was the abiraterone or the prednisone. I am on a single 5mg dose of prednisone which I moved around from morning, afternoon, and settling on after dinner. This seems to fit the best for me. My blood pressure is controlled under medication, so keep a close eye on your BP. Keep a close eye out for swelling in the joints.

I find daily exercise is crucial as well as a good diet. If I miss a few days exercise, I start to feel fatigued and fuzzy - I am not sure if this is abiraterone, or just androgen deprivation in general.

Good-luck, Winter.
Age: 51, dx at 50
10/2011 PSA 47.83, T 270
Biopsy: 11/2011: 8 of 14 cores, right side, 80-90%. GS7 (3+4)
Bone Scan: negative. CT Scan: lymph neg, soft tissue mass posterior to prostate
HT: 12/2011, start clinical trail neo-adjuvant Lupron/Abiraterone/Prednisone
1/2012 PSA 1.65, T 2 : 2/2012 PSA 0.11, T 3 : 3/2012 PSA 0.05, T 3

Southern Comfort
Veteran Member


Date Joined Jul 2011
Total Posts : 995
   Posted 3/21/2012 7:02 PM (GMT -7)   
Bud,
I know you were expecting this but hang tough! On the Prednisone: expect some initial surge in energy, increase in appetite, etc. You might feel wired. You might need a sleep aid to wind down at night until you get used to it.
Age 52; dx at 50, PSA 54.9
Nerve sparing surgery/open, 2010; removed 14 lymph nodes
Pathology report: T3bN0MX, SVI, neg margin, Gleason 9
HT: Lupron+bicalutamide, up to 36 months: 15 months so far
Finished Adjuvant RT incl lymph nodes, 9/2011
Starting adjuvant Taxotere
Latest PSA <0.005

F8
Veteran Member


Date Joined Feb 2010
Total Posts : 3280
   Posted 3/21/2012 7:35 PM (GMT -7)   
WS -- i got some pretty bad nausea from lupron.  seems like it would hit me in the late mornings.  i almost pulled over on the freeway one morning because i thought i was going to hurl, and i haven't thrown up in  21 years!
 
ed
 
 
age: 56
PSA on 12/09: 6.8
gleason 3+4 = 7
HT, BT and IGRT
received 3rd and last lupron shot 9/14/10
2/8/11 PSA <.1, T= 6 ng/dl
6/8/11 PSA .2, T = 540 ng/dl
8/19/11 PSA .3, T = 487 ng/dl
10/5/11 PSA .2, T = 530 ng/dl
3/1/12 PSA .3

F8
Veteran Member


Date Joined Feb 2010
Total Posts : 3280
   Posted 3/22/2012 9:53 AM (GMT -7)   
i hope you get it figured out.  are you hormone refractory?  maybe you make your doctor rich(er) with lupron cool .
 
ed
age: 56
PSA on 12/09: 6.8
gleason 3+4 = 7
HT, BT and IGRT
received 3rd and last lupron shot 9/14/10
2/8/11 PSA <.1, T= 6 ng/dl
6/8/11 PSA .2, T = 540 ng/dl
8/19/11 PSA .3, T = 487 ng/dl
10/5/11 PSA .2, T = 530 ng/dl
3/1/12 PSA .3

Cajun Jeff
Veteran Member


Date Joined Mar 2009
Total Posts : 3664
   Posted 3/23/2012 9:54 PM (GMT -7)   
Bud, so pleased thatbyiu still will make the GFMPH. You will have lots of infofornus and you will find great support from your GFMPH friends. Hang in there.

Cajun Jeff
9/08 PSA 5.4 referred to Urologist
9/08 Biopsy: GS 3+4=7 1 positive core in 12 1% cancer core
10/08 Nerve-Sparing open radicalSurgery Path Report Downgrade 3+3=6 GS Stage pT2c margins clea
r3 month: PSA <0.1
19th month: PSA <0.1
2 year PSA <0.1
Only issue at this time is ED but getting better
New Topic Post Reply Printable Version
Forum Information
Currently it is Wednesday, November 26, 2014 2:06 PM (GMT -7)
There are a total of 2,278,677 posts in 253,263 threads.
View Active Threads


Who's Online
This forum has 158701 registered members. Please welcome our newest member, yardsale.
338 Guest(s), 21 Registered Member(s) are currently online.  Details
flameboy, MarieLS, Summersun, KentJ, JaSanne, CheleL, pb4, Utahgal, AngelLisa, Marktheman, Sherrine, Tudpock18, Lynnwood, DazedPete, lesweet1971, jeoch, FamilyGuy, Traveler, Fred117, delilahblue, mauihawaii


Follow HealingWell.com on Facebook  Follow HealingWell.com on Twitter  Follow HealingWell.com on Pinterest  Follow HealingWell.com on YouTube
Advertisement
Advertisement

©1996-2014 HealingWell.com LLC  All rights reserved.

Advertise | Privacy Policy & Disclaimer