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Jerry L.
Veteran Member


Date Joined Feb 2010
Total Posts : 2424
   Posted 8/7/2012 9:20 AM (GMT -6)   
Anybody have any information on Losartan.  My doc suggested I take it for possible hardening of arteries.  In addition, I found this as it relates to PC:
 
 
 
 
 
11/09 Dx at Age 44 -------------- 4.03
12/09 DaVinci Surgery
1/10 T3b, G9 --------------------- <.05
2/10 Adj. Radiation -------------- <.05
3/11 PSA Rise/Scans/Spot ------- .09
on Pelvic Bone
4/11 HT / XGEVA ------------------ .06
5/11 Spot Radiation -------------- <.05
12/11 - 6/12 ------------ <.01

A Yooper
Veteran Member


Date Joined Jul 2012
Total Posts : 1617
   Posted 8/7/2012 9:52 AM (GMT -6)   
Hi Jerry,

I take Losartan/HCT 50-12.5 tab daily, for slightly elevated blood pressure. It's working in that aspect for me, inexpensive and no side affects.
55 years old, excellent health (up until this. . . .) diagnosed with PCa early July 2012
NO symptoms or signs of PC
PSA rose from 3.8 to 5.8 over past 3 years
Biopsy 6/27/12
8 of 12 Gleason: 3+3 <5%, 3+3 <5%, 3+3 <5%, 3+3 <5%, 3+4 5-10%, 3+4 <5%, 3+4 5-10%, 3+4 30-40%, 3+4 15-20% (All negative for perineural invasion)
Negative DRE (3 in the past 4 months)
NO,
MO
T1C
Gland size 40gm
Vol. 22gm

InTheShop
Veteran Member


Date Joined Jan 2012
Total Posts : 3098
   Posted 8/7/2012 11:28 AM (GMT -6)   
I take Losartan daily (75 mg) for high blood pressure and it works well. Controls BP with no real side effects for me. It is in a class of drug like Cardura that also has show some positive benefit for prostate health. I've not read the information you linked to but it sounds very possible and a nice side benefit.

I can't think of a downside to that drug or a reason not to take it. You'll just have to watch your BP for awhile to make sure it doesn't drop too much.

It doesn't cost much (there's a generic version my insurance lets me have for $10 co-pay for 90 supply).

All the best,
Andrew
I'll be in the shop.
Age 52
PSA 4.2 10/11, 1.9 6/12
GS 3+4
Stage T1C
2 out of 14 cores positive
Treatment IGRT - 2/2012
My PC blog

Salty_clark
Regular Member


Date Joined Apr 2008
Total Posts : 95
   Posted 8/7/2012 11:57 AM (GMT -6)   
I've beentaking losartan for the past 3 or 4 years...started at 50/12.5 and about 6 months ago my doc raised it to 2 pills per day or a total of 100/25. My blood pressure is stabile now at around 120/70.  Never have had any problem tolerating it.  I was unaware it had any effect on my PCa.

sequoiaranger
Regular Member


Date Joined Sep 2011
Total Posts : 236
   Posted 8/7/2012 12:18 PM (GMT -6)   
I, too, take Losartan. My insurance wouldn't cover my former BP meds (Crestor, then Zocor, then....) so switched me to Losartan. No complaints. BP varies between 120 and 137.
 
OK, please TRANSLATE the gibberish on that link: I can't tell by the language used whether Losartan PROMOTES tumor formation or INHIBITS it.
 
Can somebody clairfy??

Post Edited (sequoiaranger) : 8/8/2012 10:58:39 AM (GMT-6)


Jerry L.
Veteran Member


Date Joined Feb 2010
Total Posts : 2424
   Posted 8/7/2012 12:26 PM (GMT -6)   
I guess that is one of my questions to the forum as well. I don't speak that language well either.
11/09 Dx at Age 44 -------------- 4.03
12/09 DaVinci Surgery
1/10 T3b, G9 --------------------- <.05
2/10 Adj. Radiation -------------- <.05
3/11 PSA Rise/Scans/Spot ------- .09
on Pelvic Bone
4/11 HT / XGEVA ------------------ .06
5/11 Spot Radiation -------------- <.05
12/11 - 6/12 ------------ <.01

Jerry L.
Veteran Member


Date Joined Feb 2010
Total Posts : 2424
   Posted 8/7/2012 1:12 PM (GMT -6)   
Just so we have what it says:
---------------------
BACKGROUND: Paired homeobox 2 gene (PAX2) is a transcriptional regulator, aberrantly expressed in prostate cancer cells and its down-regulation promotes cell death in these cells. The molecular mechanisms of tumor progression by PAX2 over-expression are still unclear. However, it has been reported that angiotensin-II (A-II) induces cell growth in prostate cancer via A-II type 1 receptor (AT1R) and is mediated by the phosphorylation of mitogen activated protein kinase (MAPK) as well as signal transducer and activator of transcription 3 (STAT3).

METHODS: Here we have demonstrated that A-II up-regulates PAX2 expression in prostate epithelial cells and prostate cancer cell lines resulting in increased cell growth. Furthermore, AT1R receptor antagonist losartan was shown to inhibit A-II induced PAX2 expression in prostate cancer. Moreover, analysis using pharmacological inhibitors against MEK1/2, ERK1/2, JAK-II, and phospho-STAT3 demonstrated that AT1R-mediated stimulatory effect of A-II on PAX2 expression was regulated in part by the phosphorylation of ERK1/2, JAK II, and STAT3 pathways. In addition, we have showed that down-regulation of PAX2 by an AT1R antagonist as well as JAK-II and STAT3 inhibitors suppress prostate cancer cell growth.

RESULTS: Collectively, these findings show for the first time that the renin-angiotensin system (RAS) may promote prostate tumorigenesis via up-regulation of PAX2 expression.

CONCLUSIONS: Therefore, PAX2 may be a novel therapeutic target for the treatment of carcinomas such as prostate cancer via the down-regulation of its expression by targeting the AT1R signaling pathways.
11/09 Dx at Age 44 -------------- 4.03
12/09 DaVinci Surgery
1/10 T3b, G9 --------------------- <.05
2/10 Adj. Radiation -------------- <.05
3/11 PSA Rise/Scans/Spot ------- .09
on Pelvic Bone
4/11 HT / XGEVA ------------------ .06
5/11 Spot Radiation -------------- <.05
12/11 - 6/12 ------------ <.01

goodlife
Veteran Member


Date Joined May 2009
Total Posts : 2621
   Posted 8/7/2012 5:27 PM (GMT -6)   
Losartan can cause a dry cough. It is a well known SE.

I switched to benicar, and cough disappeared.
Goodlife


Age 58, PSA 4.47 Biopsy - 2/12 cores , Gleason 4 + 5 = 9 Da Vinci, Cleve.Cl 4/14/09 pT3a NO MX,
Neg Margins, PSA 6 wk,<.03, 3 mo. <.01 (dif lab),
mo. <.03 , 6 mo. <.01, No pads, 1/1/10, 9 mo. < .01, 1 year .01, 15 mo. <.01, 18 mo. .01, 21 mo. .02, 24 mo. .03, 27 mo. .02 , 30 mo .02, 33 mo .04, 36 mo. .06. 37 mo. .06
SRT begun 6/14/12

sequoiaranger
Regular Member


Date Joined Sep 2011
Total Posts : 236
   Posted 8/8/2012 11:57 AM (GMT -6)   
OK...let me see if I have this right. Extracting a few key phrases from the "gibberish",

"...it has been reported that angiotensin-II (A-II) induces cell growth in prostate cancer.."

"...AT1R receptor antagonist losartan was shown to inhibit A-II induced PAX2 expression in prostate cancer."

it would *APPEAR* that Losartan does indeed help (however much) to reduce prostate cancer cell growth.

Anyone see it differently?? I would hate to be "wrong". I had been prescribed Losartan, so of course I am interested in what its use might result in. I certainly don't want to be taking something that ENCOURAGES pc!!!!!
Gleason 9, RPP 2/2007. PSA rising, neither Lupron nor Provenge working anymore. Got Radiation. Now on Taxotere, PSA dropping----crossing my fingers!

Jerry L.
Veteran Member


Date Joined Feb 2010
Total Posts : 2424
   Posted 8/8/2012 7:33 PM (GMT -6)   
Squoiaranger --- I read it the same way.

I emailed my doctor and got a vague answer. I'm trying to clarify it. He says it has a mild impact on PC. I think he means in the good way.
11/09 Dx at Age 44 -------------- 4.03
12/09 DaVinci Surgery
1/10 T3b, G9 --------------------- <.05
2/10 Adj. Radiation -------------- <.05
3/11 PSA Rise/Scans/Spot ------- .09
on Pelvic Bone
4/11 HT / XGEVA ------------------ .06
5/11 Spot Radiation -------------- <.05
12/11 - 6/12 ------------ <.01

PDL17
Regular Member


Date Joined Oct 2011
Total Posts : 254
   Posted 8/8/2012 8:10 PM (GMT -6)   
Losartan is an angiotensin receptor blocker, therefore it decreases the effect of angiotensin II.  That means, theoretically, losartan would be good for prostate cancer.
 
It is possible losartan can cause dry cough, but highly unlikely.  ACE-Is (angiotensin converting enzyme inhibitors) are the drugs implicated most with dry cough.  That is why drugs like losartan and Benicar are often substituted in patients exhibiting that side effect with ACE-Is (lisinopril, captopril, ramipril, enalapril, etc).
 
Losartan is a very good drug for blood pressure and congestive heart failure.  It may have a beneficial effect on prostate cancer.
 
Good luck!
 
Paul
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