Zytiga stopped working.

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Jitters99
Regular Member


Date Joined Jan 2011
Total Posts : 222
   Posted 8/9/2012 9:08 PM (GMT -6)   
My husband has been on Zytiga for 10 weeks and PSA is now rising quickly. Actually started to rise at 8 weeks..went from 38 to 111 in 7 days..Dr. Said he didn't tell us because he felt that was impossible, had to be a lab error. Two weeks we go back for test and it's now 269....So we head back to Las Vegas to see Dr. Voxgelzang, he says most likely more chemo. Taxotera did work, stopped after 6 treatments, every three weeks. Do they try a different chemo, increase the amount of prior chemo, more often, what have you experienced? Sounds like our one month trip back for just a check up and Zytiga keeping him stable now will turn into months of therapy, and we so wanted to be in CT for fall foliage.
Needless today has been so depressing, and to top it off the pain injection he got a month ago on his spine has stopped helping, so we may have to move fast and get a second injection before he starts chemo...no steriod injections during chemo because his WBC goes to low..goes into septic shock. Again on the rollercoaster.

Purgatory
Elite Member


Date Joined Oct 2008
Total Posts : 24280
   Posted 8/9/2012 9:15 PM (GMT -6)   
Sorry so to hear this news, your story was hard to read and think about. Sounds like you are doing all the things you can be doing, please never give up hope at this point. Hope they can get his pain back under control again, he doesn't need to be dealing with that on top of the fast rising PSA.

Best hopes and wishes to both of you,

david
Age: 60, 56 at PC dx, PSA 16.3
3rd Biopsy: 9/8 7 of 7 Positive, 40-90%, 4+3
open RP: 11/8, Catheter in 63 days
Path Rpt: 3+4, pT2c, 42g, 20% tumor, 1 pos margin
Incont & ED: None
Surgery Failed, recurrence within 9 months
Salvage Radiation 10/9-11/9, SRT failed within 9 months, PSA 4/12 = 37.x
Spent total of 1 ½ years on 21 catheters, Ileal Conduit Surgery 9/10,
7 other PC-related surgeries
Member of Prostate Cancer & Chronic Pain HW Communities since 10/2008
“I live in the weak and the wounded” – Session Nine (Movie)

Raddad
Veteran Member


Date Joined Jul 2011
Total Posts : 1857
   Posted 8/9/2012 9:37 PM (GMT -6)   
Jitters99

Have you and hubby considered MDV3100?

nhwife and C.C. hubbies have recently started that
http://www.healingwell.com/community/default.aspx?f=35&m=2464612&p=1

Sorry I can't help with the chemo questions, I'm hoping to avoid that.

HUGS to you both

Bud

We will beat this crap
65 - April 2013
Gonna Make Myself A Better Man tinyurl.com/28e8qcg
12 Jul 11 - 1447 (It's just a number! )
Scans showed active prostate cancer widespread in bones
Started HT treatments and Zometa for bone
31 Oct 11 - 46.6 Cheers!
25 Jan 12 - 75 - Crap
22 Feb - 99 - Restarted Casodex
22 Mar - 149 - Start Zytiga
25 Apr - 113
22 May - 66
19 Jun - 38
19 Jul -34 - Still going down!

Zimac
Veteran Member


Date Joined Mar 2012
Total Posts : 600
   Posted 8/9/2012 9:56 PM (GMT -6)   
Jitters99,

So sorry to hear about what is going on with your husband. Can't they give him something to take by mouth for his pain until the chemo kicks in? His pain is the priority.

I understand your depression today but remember to try to take one moment at a time. We too ride the roller coaster. It's a ride we rather not be on. If you need to talk, you can contact me at any time.

Wishing you both the best.

Zimac
Age 60, Dx'd 56 -2008, PSA 6.4
12/2008-open RP, nerve sparing
Path: Gleason - 4+3, clear margins
1/2009 - Bone Mets
7/2009 - Lupron, Zometa
3/11 - Lung Mets confirmed
11/11 - Zytiga, not effective
4/12 - Taxotere, PSA 23
Failed Taxotere
7/23 - starting monoclonal antibody therapy (clinical trial)
Living for the moment

Southern Comfort
Veteran Member


Date Joined Jul 2011
Total Posts : 994
   Posted 8/9/2012 10:17 PM (GMT -6)   
Jitters99,
I am sorry to hear the news. They can do Taxotere every 3 weeks or every week .. different doses of course. I think the standard 3-week Taxotere dose for advanced PCa is 75 mg/m2. Jevtana is a 2nd line chemo for when Taxotere fails. I think your priority is pain control and slowing the PSA rise way down. Chemo is probably the right answer on both counts. Get those under control and then maybe other treatment options can come into play. Of course, Dr. Voxgelzang is the expert and will have definitive plans. Good luck and best wishes.
SC
Age 52; dx at 50, PSA 54.9
open RP, 2010; removed 14 lymph nodes
Pathology report: T3bN0MX, SVI, neg margin, Gleason 9
HT: ADT2, 36 months: 16 months left
Finished Adjuvant RT, 75.6 Gy, 9/11
Finished Adjuvant Taxotere (6 x 60 mg/m2), 6/12
Latest PSA <0.03, T=11

c.c
Regular Member


Date Joined Jun 2012
Total Posts : 62
   Posted 8/10/2012 12:57 AM (GMT -6)   
Dear jitter99,

I am sorry you are here but it is the best place to be to get information about what you are going through ..
My husband also did the taxatere the jevtana and the zytiga and now he is in the mdv3100 trial he is mcrpc metastatic castrate resistant prostate cancer in simple terms stage 4 prostate cancer with bone mets gleason 9:( i am assuming that since your husband is doing the same treatments mine did he is around the same diagnosis . ( i pray hes not) anyway we retried the jevtana once the zytiga failed at a lower dose it failed for us but others have had success with it .
I am going to be honest with you we are not in the best spot and our options are limited at this point :( After all the research and people here and other sites i have talked too (doctors onc...ect clinical trials is the next step if all your options (chemos) have run their courses.i am sorry for this i am soo hoping i am giving advice that fits you and your husband dx :) i am in no way a doctor or medical anything other then a loving caregiver to my amazing husband:)
As for the pain they should be able to give him pain meds now that he is off chemo although my husband was and still is on pain meds and chemo ... have you thought of taking a vacation from treatment for the fall we took a 2 month vacation :) alot of people do it , it gives you a chance to breath and get your bearings lol i hope this helps you and i am sorry if the info i have given wasnt for the stage you are in but hope it helps in some way
best wishes and hugs
C.C.
dx 9/2008 stage 4 bone mets in rib and hip age 52 @dx age 56 now gleason 9
2010 mets rib hip spine
2011 mets. rib hip spine shoulder legs
taxotere jevtana zytiga /lupron/casadex
psa6/2/12-78.04-5/13/12-32.48-4/22/12-19.32-3/26/12-16.04-1/31/12-9.11
7/24/2012 mdv3100 trial psa202.1

nhwife
Veteran Member


Date Joined Mar 2012
Total Posts : 721
   Posted 8/10/2012 5:18 AM (GMT -6)   
jitters99, your story is a hard one to read. Many of us have been in the place you are: one treatment failed, what next. Zytiga and taxotere both failed for my husband. He is on MDV3100 right now but we don't know the effect yet. We are having good days now but some days I feel it's a false sense of security as i wonder what the MDV3100 IS doing.
I think there will always be options. Some may work for just a little, some may work for longer. As long as the beast is somewhat managed, I am good with that.
Everyone is right about the pain - that does need to be addressed. No one should be in pain and the doctors should be able to address that.
Everyone here is rooting for you and your husband. You are not alone in this battle which we will win somehow and someday.
Hubby, dx 2002, age 50
PSA 6.8 Gleason 7 (4+3)
Surg Jan 2003
G7pT3c perineural involve., sem. ves., neg. margins
2005 rising PSA
2006 RT, HT
2008 Cas, Zometa
2011 Keto
PSA Dec. 2011 20.2
2012 Zytiga PSA March 2012 14
March 30 - PSA 18, some lymph node tumor growth
April - stopped zytiga, begin Taxotere PSA 20
Taxotere: 4/30/12, 5/21, 6/11
PSA 30 Tax stopped
MDV3100

sequoiaranger
Regular Member


Date Joined Sep 2011
Total Posts : 236
   Posted 8/10/2012 11:27 AM (GMT -6)   
I am currently on Taxotere (6th infusion the most recent) and the six has been extended to ten, since I am showing positive (lowering of PSA) results. After four PSA plunges of some 30% each, my last test showed only a 6% drop---not very terrific, but still a drop. I *MAY* be at the end of Taxotere's usefulness, but it has brought about a marked lessening of bone pain and allowed my "life" to get back to near-normal. The initial six infusions was just part of the "plan" and an evaluation point. The next four (actually the next ONE) will tell me if I should continue with it.
 
It seems a little odd that AFTER Taxotere failed, Jetvana would be ordered, as they seem the same "class" of taxane-derivative.

Post Edited (sequoiaranger) : 8/10/2012 10:31:00 AM (GMT-6)

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