Xgeva and Zytiga together.

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OregonKid
New Member


Date Joined Aug 2011
Total Posts : 10
   Posted 2/14/2013 10:09 PM (GMT -6)   
Been quite a while since I have posted. I will be starting Zytiga in March. Eligard has stopped working after two years. My doctor said that I can't take Zytiga and exgiva together. Anyone have any experience with this. Gotta protect those bones.

Thanks,
George

JohnKeats
Regular Member


Date Joined Jun 2012
Total Posts : 209
   Posted 2/15/2013 10:16 AM (GMT -6)   
Some alternatives to XGiva is Zometa or Aridia. I've been on all three, currently on Zometa. XGiva was starting to give me bone pain. So maybe the other two can work with Zytiga.
Diagnosed 9/14/2011; Age 47; PSA 5,000+
Metastatic Stage 4, spread to entire skeleton w/femur fracture
Current therapy: Lupron/Casodex/Aredia
June 4, 2012: PSA 2.2
June 27, 2012: PSA 1.42
July 24, 2012: PSA 0.69
September 25, 2012: PSA 1.2
October 11, 2012 PSA 1.4
December 10, 2012 PSA 3.79 (starting tripling Casodex dosage)
January 14, 2013 PSA 2.88

mbisoux
Regular Member


Date Joined Aug 2012
Total Posts : 55
   Posted 3/5/2013 9:10 PM (GMT -6)   
Hello! My husband is about to start on Zytiga, too (the oncologist just called to tell him he was not accepted in the clinical trial for GTX-758 so we are moving on to Zytiga). Dr. Flaig did not mention anything about the Xgeva, which Marshall also takes. I guess we'll learn more about that later.

But your posts bring up another question: Marshall has been having SEVERE bone pain for the past month and our oncologist has done several sets of x-rays and scans and he does not believe the pain is totally cancer related. I had read that sometimes Xgeva causes bone pain and that if you switch to another bone strengthener like Zometa the bone pain stops.

I asked Dr. Flaig about that and he said that is possible, but that he feels Zometa is too toxic.

Do any of you have any opinions or experience with this?
Marilyn
Diagnosis: 3/17/12 Stage IV prostate cancer, mets to bone
Gleason Score: 8
3/29/12 Two Firmagon shots
4/30/12 HT changed to Lupron, 3-month injections
9/13/12 First injection of Xgeva
PSA 3/17/12 49; 3/29/12 99; 4/30/12 9; 6/15/12 3.9; 7/26/12 3.9; 9/13/12 6.6; 10/11/12 10.2; 11/21/12 10.2; 1/17/13 13.2
9/13/12 6.6 (onc wants new bone scan and CT scan)
12/20/12 5 days of radiation to spine

Concerned4You
Regular Member


Date Joined Dec 2010
Total Posts : 87
   Posted 3/7/2013 1:19 PM (GMT -6)   
My Dad takes Xgeva and Zytiga together. He started last month - so far so good. No bone pain. They told him he could not take Prolia and Zytiga together that it had to be Xgeva instead. They didn't say why though.

tednsal
Regular Member


Date Joined Sep 2012
Total Posts : 204
   Posted 3/7/2013 11:15 PM (GMT -6)   
Here's my 2 cents worth: Husband on Xgeva, Xtandi and Trelstar. Bone pain is side effect of Xgeva and Xtandi. Zometa is an infusion where Xgeva is an im injection (meds are frozen and need to be thawed out for about 20 minutes before injecting). Sometimes pain more severe than usual but able to take lortab and it(pain) subsides. Suspect that if Xtandi fails then Zytiga will be the next process for us......
Age: 68: PSA age 55: 10.9 11/99
Gleason score: left: 3+3=6 right: 4+3=7
Radical Prostatectomy/Johns Hopkins 04/00
Radiation: 37
5/00 to 11/06 PSA stayed at 0.1- Lupron until January 04
PSA: 0.16-09/04 Back on Lupron inject
PSA: 2.1 -09/09 - Casadex & Lupron PSA down
PSA 4.3 - 09/11 - Bone & CT 5 spots (skull,ribs,illiac & sacrum
PSA 06/12: 196; taxotere; PSA 12/12: 26
Xtandi: 01/13 PSA - 13.20

Raddad
Veteran Member


Date Joined Jul 2011
Total Posts : 1857
   Posted 3/8/2013 10:23 AM (GMT -6)   
I was on Zytiga and Zometa for a few months with no issues at all
65 - April 2013
A Better Man tinyurl.com/28e8qcg
12 7 11 - 1447 (It's just a number! )
Scans showed active prostate cancer widespread in bones
HT treatments & Zometa for bone
31 10 11 - 46.6
25 1 12 - 75 - Crap
22 2 - 99
22 3 - 149 - Start Zytiga
25 4 - 113 | 22 5 - 66 | 19 6 - 38 | 19 7 -34
21 8 - 27.4 | 21 9 - 36.8 | 6 10 - 33 | 16 11 - 66 | 14 12 -90| Taxotere started 9 Jan 2013
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