PFS, does it mean AFTER treatment?

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smurfine78
Regular Member


Date Joined Nov 2012
Total Posts : 94
   Posted 4/25/2014 7:49 AM (GMT -6)   
I'm looking at this trial: http://prostatecancerinfolink.net/2012/07/17/does-abiraterone-acetate-resistance-induce-cross-resistance-to-docetaxel-based-chemotherapy/

When they speak of PFS at 4.6 months, does it mean 4.6 months after finishing chemo, or from the day you start chemo? Because most men are still on treatment when 4.6 months have passed.

Tall Allen
Veteran Member


Date Joined Jul 2012
Total Posts : 8610
   Posted 4/25/2014 5:52 PM (GMT -6)   
"Median time to PSA progression was the time from start of docetaxel therapy until PSA progression as defined by PCWG 2 criteria. "
annonc.oxfordjournals.org/content/23/11/2943.long

Worried Guy
Veteran Member


Date Joined Jul 2009
Total Posts : 3709
   Posted 4/25/2014 7:32 PM (GMT -6)   
Smurf,

You already received your answer. I just needed to share something else with you.

I read this question first thing in the morning, while sitting in front of my pc at the kitchen table.
I don't know if it was my circadian hormonal cycle or if I had had too much soy milk in my coffee, but when I read your Q and thought about it for a minute, it hit me hard. I teared up and could not talk.
Basically, you were asking something like "Is it 4 months, 8 months, or 12 months?"
Your question brought home a reality I've been lucky enough to ignore. Thank you for waking me.

I don't know if you are male, female, married, single - and I don't care! I need to give you a hug!

(((Hugs)))
Jeff

(Tomorrow will be different. I am drinking my coffee black!)
Age: 61, Mar 38 yrs, 56 dx, PSA: 4/09 17.8, 6/09 23.2
Biopsy: 6/09 Pos 7/12, 20-70%, G 4+3, Bone, CT Neg
DaVinci RP: 7/09, U of Roch Med Ctr
Path Rpt: G 3+4, pT3aNOMx, 56g, Tumor 2.5x1.8 cm both lobes and apex
EPE pres., PNI exten., Sem Ves, Vas def clear, Lymph 0/13
Incont.: AdV Sling 1/11
ED: Quadmix
PSA: 10/09 .04, 7/10 <0.01, 7/11 <0.01, 1/12 <0.02, 9/12 <0.02, 4/13 <0.02, 3/14 <0.02!

Post Edited (Worried Guy) : 4/26/2014 4:09:11 PM (GMT-6)


smurfine78
Regular Member


Date Joined Nov 2012
Total Posts : 94
   Posted 4/26/2014 2:58 PM (GMT -6)   
Thanks :) I was just wondering, but I'm not that worried, because my dad has been lucky all the way. He has responded well to all therapies. If he had followed the prognosis he should have been dead many years ago. And there are many more available medications available now than several years ago :)
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