New Topic Post Reply Printable Version
[ << Previous Thread | Next Thread >> ]

Malcolm Tent
New Member


Date Joined Sep 2017
Total Posts : 7
   Posted 9/11/2017 3:13 PM (GMT -6)   
Just found out my PSA was .23 in 2008 and now at 3.9 with a steady climb since then. With a 5/12 biopsy G6, is there any real decision to make about AS vs taking action with RP or radiation?
Diagnosed 14 Aug 17
PSA 4.0 increasing from 3.0 since 2014
Gleason 6
5/12 positive biopsy.
Trying to decide what to do.
Whole grain plant-based plus sockeye salmon.

ASAdvocate
Veteran Member


Date Joined Feb 2015
Total Posts : 568
   Posted 9/11/2017 3:59 PM (GMT -6)   
Why not order an OncotypeDX or Prolaris genomics test on your biopsy cores? They are sometimes a tie-breaker when a biopsy has more cores than most guidelines suggest.

Here is a good article about Johns Hopkins' AS program, which I have been participating in for eight years.

https://urology.jhu.edu/newsletter/2016/Discovery2016.pdf
DOB: May 1944
In AS program at Johns Hopkins
Five biopsies from 2009 to 2014. The third and fourth biopsies were positive with one core and three cores <5% and G 3+3. Fifth biopsy was negative.
OncotypeDX: 86 percent chance of PCa remaining indolent
August 2015: tests are stable; no MRI or biopsy this year for my AS program
August 2016: MRI unchanged from 2/2014; PSA=3.9; FPSA= 26; PHI =28

Tall Allen
Veteran Member


Date Joined Jul 2012
Total Posts : 8384
   Posted 9/11/2017 8:26 PM (GMT -6)   
For me, AS would be a clear and obvious choice. For you, it may not be. I don't see any reason to adhere to a #of cores criterion as long as you have a really good confirmatory biopsy. But that's me. You have to do what makes you feel comfortable.
Allen - not an MD
•PSA=7.3, prostate volume=55cc, 8/17 cores G6 5-35% involvement
SBRT 9 yr onc. resultsSBRT 7 yr QOL results
•treated 10/2010 at age 57 at UCLA,PSA now: 0.1,no lasting urinary, rectal or sexual SEs
my PC blog

InTheShop
Veteran Member


Date Joined Jan 2012
Total Posts : 7631
   Posted 9/11/2017 8:55 PM (GMT -6)   
I wanted to do AS, but the docs talked me out of it. In your case, on a good AS program you'd be fine.

But it is your choice and sometimes based on what makes you feel comfortable and what you can live with. For some, the anxiety is too much. Not an easy decision.

Andrew
I'll be in the shop.
Age 57, 52 at DX
PSA:
4.2 10/11, 1.9 6/12, 1.2 12/12, 1.0 5/13, .6 11/13,
.7 5/14, .5 10/14, .5 4/15, .3 10/15, .3 4/16, .4 10/16, .4 5/17
G 3+4
Stage T1C
2 out of 14 cores positive
Treatment IGRT - 2/2012
My latest blog post

Subdenis
Regular Member


Date Joined Aug 2017
Total Posts : 94
   Posted 9/12/2017 2:39 AM (GMT -6)   
The # of cores being less than 3, I believe was driven by a low number of cores taken at biopsy when the standard was developed. SO if you did a 4 core biopsy and found 2 positive that is 50% but if you do 12 and find 2, clearly less. One of the good news is it is all 3+3. One other metric is the% core involvement. if that is low it may inform you. I am awaiting decipher test results to support my decision. I (we) must remember this is a slow growing cancer. At the PCRI conference, many of the docs were still in the debate as to is G6 cancer and a couple stated there has been no evidence the G6 ever caused a cancer death.

I also get the indecision part. AS is as much science as it is philosophy IMHO, we all are making a bet no matter which way we go. I say trust your intuition. I wish you well. Denis
65 YO healthy man, PSA 4.1/2 for couple years PSA 5/1/17 4.6, Multiparametric MRI, 5/15/17 showed lesion. 13 core biopsy 3 positive 3+3 and one positive in lesion, may be overlap All cores less than 30% 8/22/17 - second opinion Yale pathology shows small amount of (3+4) in one core, < 5%, ordered decipher to inform next steps Leaning towards Active Surveillance. Thanks, Denis

NKinney
Veteran Member


Date Joined Oct 2013
Total Posts : 532
   Posted 9/12/2017 8:46 AM (GMT -6)   
Here's a point of reference: For "high-volume" 3+3 cases, Dr Klotz has commented at the 2016 AUA conference that he would recommend an mp-MRI and targeted biopsy to confirm your likely eligibility into his AS program.

You don't, however, qualify as a "high-volume" 3+3 case...you have less.

Malcolm Tent
New Member


Date Joined Sep 2017
Total Posts : 7
   Posted 9/12/2017 5:46 PM (GMT -6)   
Just found out my DNA report came back very unlikely so my surgeon backed off the RP and said I would be a good candidate for short term AS whatever that means. I'll follow up on that. Still having issue with the fact that if the biopsy only hits about 1% of the prostate and they hit 5/12, that tells me its pretty prevelant. I sent my biopsy to JHs today for a second opinion and am seeing proton and brach specialists this week.
Diagnosed 14 Aug 17
PSA 4.0 increasing from 3.0 since 2014
Gleason 6
5/12 positive biopsy.
Trying to decide what to do.
Whole grain plant-based plus sockeye salmon.

Michael_T
Veteran Member


Date Joined Sep 2012
Total Posts : 2407
   Posted 9/12/2017 7:13 PM (GMT -6)   
The advantage of a good AS program is that if there is something else there, it will find eventually find it. And in the meantime, AS is considered safe with a 20-year study to back that up.

Some people aren't cut out for AS and I completely understand it. But if you're okay with it on the emotional side, you shouldn't worry that you're putting yourself at risk.

BTW, good decisions with sending the biopsy to JHU and seeing the other specialists. That's all part of good due diligence. Good luck to you!
Age 56, Diagnosed at 51
PSA 9.6, Gleason: 9 (5+4), three 7s (3+4)
Chose triple play of HDR brachy, IMRT and HT (Casodex, Lupron and Zytiga)
Completed HT (18 months) in April 2014
3/17: T = 167, PSA = 0.13

Tall Allen
Veteran Member


Date Joined Jul 2012
Total Posts : 8384
   Posted 9/12/2017 7:56 PM (GMT -6)   
Malcolm Tent,
Fortunately for you, prevalence is not a big risk factor when it's all GS6. In fact, at Johns Hopkins they found that the % remaining free from disease 5years after RP was statistically no different if there were originally more or less than 6 positive cores. It might mean AS won't last for 20 years, but even if it lasts 5 years, why not?

/www.ncbi.nlm.nih.gov/pmc/articles/PMC3978182/
Allen - not an MD
•PSA=7.3, prostate volume=55cc, 8/17 cores G6 5-35% involvement
SBRT 9 yr onc. resultsSBRT 7 yr QOL results
•treated 10/2010 at age 57 at UCLA,PSA now: 0.1,no lasting urinary, rectal or sexual SEs
my PC blog
New Topic Post Reply Printable Version
Forum Information
Currently it is Tuesday, September 19, 2017 1:03 PM (GMT -6)
There are a total of 2,870,426 posts in 314,999 threads.
View Active Threads


Who's Online
This forum has 156498 registered members. Please welcome our newest member, Nay91.
516 Guest(s), 14 Registered Member(s) are currently online.  Details
alephnull, countess18, mbock, tennisplayer, theskyking123, groombridge, Tudpock18, Lynnwood, Mrbaseball220, Nay91, Jerry_Delaware, mareish, MartinP, Tall Allen


Follow HealingWell.com on Facebook  Follow HealingWell.com on Twitter  Follow HealingWell.com on Pinterest
Advertisement
Advertisement

©1996-2017 HealingWell.com LLC  All rights reserved.

Advertise | Privacy Policy & Disclaimer