DNA test question

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LupnerRN
Regular Member


Date Joined Sep 2008
Total Posts : 350
   Posted 11/28/2012 6:22 PM (GMT -6)   
My son was tested using the DNA mouth swab. We knew about gluten sensitivity so his Lyme doctor wanted him tested further.

He had 1 celiac gene and 1 gluten sensitivity gene.
The question is how many celiac genes do you need to have for gluten to potentially cause GI and other organ damage?

He does not have any symptoms after eating wheat. Hes only seven. Is it more from long term exposure?

And do the people who react severely carry more genes?

Thanks for any thoughts,
Lisa

Razzle
Veteran Member


Date Joined Aug 2007
Total Posts : 4130
   Posted 12/12/2012 9:13 AM (GMT -6)   
I have 1 Celiac gene and 1 Gluten Sensitivity gene. Gluten affects me severely. All it takes is one gene...the more genes, the more likely one is to react. I don't think more genes = more damage, it just increases the likelihood of Gluten Sensitivity or Celiac.
-Razzle

Chronic Lyme, Bart., Gluten & Sulfite Sensitivity, Many Food/Inhalant/Medication/Chemical Allergies & Intolerances, Asthma, Gut dysmotility & non-specific inflammation, Lupus, Osteoporosis, etc.; G-Tube
Meds: Flagyl, Domperidone, Claritin, Andrographis & other herbs, homeopathy, supplements, etc.

LupnerRN
Regular Member


Date Joined Sep 2008
Total Posts : 350
   Posted 12/12/2012 8:26 PM (GMT -6)   
hey thanks Raz!

You can only inherit 2 of each type of gene, right???
I've always been curious why some people react more severely than others, even if they only carry one celiac gene, and why some people start having physical symptoms at earlier ages than others.

The human body is soooo mysterious. It makes no sense sometimes.
11/07 symptoms start
7/4/08 IGenX LD positive,gluten sensitivity,low magn, low WBC's,+yeast/bacteria/tapeworm/roundworm, EBV,HHV,CMV,Parvo,
7/25/08 started on Biaxin ]9/08 IGenX co-infections neg, but probable Bart, Bab, Erhl 2009-10 combo pharma and herbal
11/10-2/12 IV meds not working

kerid
New Member


Date Joined Dec 2012
Total Posts : 11
   Posted 12/21/2012 10:56 PM (GMT -6)   
i didn't know there were different genes! one for gluten-sensitivity and one for celiac!

me, and my 2 daughters are dq2 heterozygous (high risk of celiac)
husband is dq8 heterozygous (moderate risk of celiac)
son is dq2-, dq8- (extremely low risk of celiac)

so which one is for which? thanks!

Razzle
Veteran Member


Date Joined Aug 2007
Total Posts : 4130
   Posted 12/23/2012 6:20 AM (GMT -6)   
LupnerRN,

Yes, everyone gets 2 copies of each gene - 1 from each parent.

kerid,

DQ2 and DQ8 are both Celiac genes.

DQ1 and DQ3 are Gluten Sensitivity genes. But it is more complicated than that, because of how genes are labeled.
See /enterolab.com/StaticPages/FaqResult.aspx and scroll down to "Why are gene results so complicated, and which genes predispose to gluten sensitivity/celiac sprue?"
-Razzle

Chronic Lyme, Bart., Gluten & Sulfite Sensitivity, Many Food/Inhalant/Medication/Chemical Allergies & Intolerances, Asthma, Gut dysmotility & non-specific inflammation, Lupus, Osteoporosis, etc.; G-Tube
Meds: Flagyl, Domperidone, Claritin, Andrographis & other herbs, homeopathy, supplements, etc.

Recoveryme2day
Regular Member


Date Joined Jul 2012
Total Posts : 332
   Posted 2/6/2013 5:22 AM (GMT -6)   
Hi LupnerRN, I was just wondering why they tested your son in the first place if he doesn't have any symptoms? Did I miss something in your post? We can be wheat intolerant and not gluten and the other way around, there's also dairy and/or soy and several severe stomach issues that can cause the intolerance or mimic the symptoms. I hope he is doing better now, my son had the "finicky" stomach. He couldn't tolerate ANY formula and he's the only kid I know of who actually IS allergic to broccoli and brussel sprouts and every vegetable except tomatoes, beans and carrots. He's grown out of the projectile vomiting stage, he's 17 but he still can't eat any of those things and he can only have dairy in moderation. Please let us know what you find out :)
Crainiotomy Lg. Meningioma Dec.02, Bi-Polar 2004, SMI 06, Gluten/Wheat/Dairy Intolerance, IBS 06, Migraines w/pseudo-seizures 07, Dev. Septum Sur. Sept.07, 2nd Men./Tumor Gamma Knife Rad. Dec.08, Radical Hysterectomy Sept.09 w/instant Menopause, Fibromyalgia 09, Disability since 09, EBV/CFS 11,Vomiting/Multiple Ulcers, Vertigo 12, Chronic Fatigue Moderator 2013.No meds list I ran out of space.

Elojik
New Member


Date Joined Feb 2013
Total Posts : 11
   Posted 2/19/2013 9:52 PM (GMT -6)   
Have both HLA-DQ8 and HLA-DQ2, celiac disease can effect almost any organ, however after long term untreated celiac disease, I developed neurological complications specifically spinocerebeller disease, the nonfatal form;I also developed arthritis. Spinocerebeller disease can mimic many neurological diseases. Also the genetic tests are only for exclusion purposes. If you do not have the genes you have a extremely low probability of having either celiac disease or gluten sensitivity.
Student 27
IBD 12/2012 Ulcrative Colitis Left Sided and oddly the Illium 1/2013
Celiac Disease 7/2008 Endoscopy, DNA panel, and Celiac Panel all positive.
Asacol 3 times per day 2.4 Grams
Rowasa 4 Grams Nightly
Prednisone
Vitamin D & Calcium
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