Flattened villi but no coeliac??

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Vicksen
New Member


Date Joined Nov 2014
Total Posts : 5
   Posted 11/25/2014 4:04 AM (GMT -6)   
Hi there
I have just had an endoscopy as I have suffered from stomach problems most of my teenage and adult life. Lately it's been incredibly bad heartburn with the sensation of food getting stuck on the oesophagus. It was confirmed that there was no abnormality upon investigation however, the gastroenterologist did say that the villi are flat and that she will be testing me for coeliac disease. I have been tested before for this and I don't have either gene for it. It's always come back negative. Could it be a gluten intolerance? So confused! I had Graves' disease (hyperthyroidism) which was treated about 11 years ago. I don't want to keep doing damage to my gut but not sure what else could cause this?? I'm a 38 year old female. Thanking you all in advance x

kazbern
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Date Joined May 2010
Total Posts : 8382
   Posted 11/25/2014 12:56 PM (GMT -6)   
What makes you think that celiac is only genetic? The gold standard is blood tests for certain antibodies plus biopsy via endoscopy that shows damage to the villi.

http://www.csaceliacs.org/diagnosis_of_celiac_disease.jsp
*******************
52 yrs old, IBD diagnosis in spring '01. Proctitis, gastritis, ileitis.
Currently taking Pentasa (3g/day) generic Colazal (9 6 pills/day), Sulfazine (1.5 g/day), Prevacid, folic acid, vit. D (2K iu), flax seed oil (2 tsp/day), psyllium (2 tsp daily), mesalamine enema as needed. Gluten free as of 5/30/11. Scope in 8/11 found no evidence of inflammation!

Vicksen
New Member


Date Joined Nov 2014
Total Posts : 5
   Posted 11/25/2014 2:35 PM (GMT -6)   
I've had both but negative. My doctor told me it is incredibly unlikely if I do not have either gene for it to have it.
Just wondering what the flat villi could mean?

kazbern
Veteran Member


Date Joined May 2010
Total Posts : 8382
   Posted 11/25/2014 3:26 PM (GMT -6)   
Vicksen said...
...I have been tested before for this and I don't have either gene for it. It's always come back negative. ...


Vicksen said...
I've had both but negative. My doctor told me it is incredibly unlikely if I do not have either gene for it to have it.
Just wondering what the flat villi could mean?


I am confused. You've had both what? You've been tested "for this" meaning what test? What does "negative" mean in your posts?

The point I was trying to make is that diagnosing celiac disease doesn't have anything to do with genetic testing. The blood tests shown on the website I provided are for antibodies your body might make to gluten. This is not a test of your genes.

I am intolerant of gluten but do not have antibodies or flattened villi, at least not that has shown up in tests.
*******************
52 yrs old, IBD diagnosis in spring '01. Proctitis, gastritis, ileitis.
Currently taking Pentasa (3g/day) generic Colazal (9 6 pills/day), Sulfazine (1.5 g/day), Prevacid, folic acid, vit. D (2K iu), flax seed oil (2 tsp/day), psyllium (2 tsp daily), mesalamine enema as needed. Gluten free as of 5/30/11. Scope in 8/11 found no evidence of inflammation!

Vicksen
New Member


Date Joined Nov 2014
Total Posts : 5
   Posted 11/25/2014 4:00 PM (GMT -6)   
I've had both the endoscopy biopsy and blood work as you stated!
They have come back clear, however I have the flattened
Villi. Again, just asking if anyone would know what else that could be caused from!!

kazbern
Veteran Member


Date Joined May 2010
Total Posts : 8382
   Posted 11/25/2014 4:06 PM (GMT -6)   
The endoscopy did not come back clear - it showed flattened villi. That is what they are looking for in the endoscopy when they are considering a celiac diagnosis. I guess your DR is going to now repeat the bloodwork to look for gluten antibodies.

By the way, with symptoms of reflux your GI should also be doing a swallow study (x-ray) and treating you with a ppi like nexium.
*******************
52 yrs old, IBD diagnosis in spring '01. Proctitis, gastritis, ileitis.
Currently taking Pentasa (3g/day) generic Colazal (9 6 pills/day), Sulfazine (1.5 g/day), Prevacid, folic acid, vit. D (2K iu), flax seed oil (2 tsp/day), psyllium (2 tsp daily), mesalamine enema as needed. Gluten free as of 5/30/11. Scope in 8/11 found no evidence of inflammation!

Vicksen
New Member


Date Joined Nov 2014
Total Posts : 5
   Posted 11/25/2014 5:11 PM (GMT -6)   
Have been taking nexium on and off for a few years. I would rather find a cause to my gastro issues and not have to take medication that fixes one thing and causes another! Nexium side effects if you are one of the unfortunate ones to have them are horrendous.
My blood work has come back clear for coeliac.

kazbern
Veteran Member


Date Joined May 2010
Total Posts : 8382
   Posted 11/26/2014 8:00 AM (GMT -6)   
If Nexium isn't doing the job then you should switch PPIs. Some people do better on one ppi than another. it's weird. I took nexium for years too, and then switched to prevacid and the prevacid cleared up my heartburn in two weeks. Not kidding.
*******************
52 yrs old, IBD diagnosis in spring '01. Proctitis, gastritis, ileitis.
Currently taking Pentasa (3g/day) generic Colazal (9 6 pills/day), Sulfazine (1.5 g/day), Prevacid, folic acid, vit. D (2K iu), flax seed oil (2 tsp/day), psyllium (2 tsp daily), mesalamine enema as needed. Gluten free as of 5/30/11. Scope in 8/11 found no evidence of inflammation!

Razzle
Veteran Member


Date Joined Aug 2007
Total Posts : 4399
   Posted 12/1/2014 7:18 AM (GMT -6)   
Flattened villi can be seen in other conditions besides Celiac. Eosinophilic Gastroenteritis is one such condition. See www.APFED.org for more info.

Eosinophilic Esophagitis causes reflux-like symptoms and food getting stuck/choking. Eosinophilic Gastroenteritis can cause flattened villi and may or may not have other symptoms (nausea, abdominal pain, diarrhea, etc.).

It would be a good idea to discuss food allergies (milk, wheat, corn, soy, egg, tree nut, peanut, fish & shellfish are the most common) and environmental allergies (tree/grass/weed pollen, dust, animals, mold, etc.) with your doctor, as food & environmental allergies are known triggers for gastrointestinal or esophageal inflammation in those with Eosinophilic Gastrointestinal Diseases (EGID's).

Other conditions that can cause flattened villi include food allergy/sensitivity/intolerance, Immune Deficiency, gastrointestinal infection (giardia, TB, Whipple's, etc.), Tropical Sprue, HIV, Autoimmune Enteropathy, Radiation Enteritis, Crohn's Disease, Intestinal Lymphoma (which may be associated with Celiac), Zollinger–Ellison syndrome, etc. Basically, anything that can cause chronic inflammation in the gut can cause flattened villi.
-Razzle

Chronic Lyme, Bart., Gluten & Sulfite Sensitivity, Many Food/Inhalant/Medication/Chemical Allergies & Intolerances, Asthma, Gut dysmotility & non-specific inflammation, Lupus, Osteoporosis, etc.; G-Tube; TPN-dependent
Meds: Zofran, Domperidone, Hydrocortisone, Essential Oils, Homeopathy, Herbs, etc.

Vicksen
New Member


Date Joined Nov 2014
Total Posts : 5
   Posted 12/1/2014 8:39 PM (GMT -6)   
Thank you south for that information. How do you test for food intolerances and the other causes?
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