How does prednisone work?

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Got2Believe
Regular Member


Date Joined Feb 2007
Total Posts : 436
   Posted 5/13/2008 12:23 PM (GMT -6)   
Can anyone explain why or how prednisone works in layman's terms. It's like my miracle drug b/c it works great and really fast for me. And this flare is my first time to take it with dinner instead of with breakfast and it seems to be better but i can't be certain.
                                                                                         
28/M/TX (revised 5/8/08)
Severe Colitis (pancolitis) since January 9, 2005
currently:  6th week flaring;improving; 2bm/day; no blood!
RX/day:  Currently 10mg of prednisone per day. Lost job and insurance 10/2007 and stopped taking asacol and Imuran cold turkey
OTC: seldom use VSL#3, vitamins & other natural treatments
Diet: SCD helps tremendously, but am not strictly on it.
Other players: food combos, enzymes, good posture, chewing more, etc.


princesa
Veteran Member


Date Joined Aug 2007
Total Posts : 2198
   Posted 5/13/2008 12:28 PM (GMT -6)   
It decreases your immune system's response, thus decreasing inflammation and pain.
Diagnosed with ulcerative colitis spring 1999.
 
Maintenance dose sulfasalazine.
Probiotics, l-glutamine and fish oil caps. George's aloe vera juice. Oregano oil antibiotic, antiviral, antifungal.
 
 


dakotagirl
Veteran Member


Date Joined Apr 2006
Total Posts : 3402
   Posted 5/13/2008 12:33 PM (GMT -6)   
Prednisone is an anti-inflammatory. It does exactly what princesa stated.

Why are you taking it later in the day? I've always read that it's best taken by 9:00 am (if you're only taking one dose per day) so that it falls in your body's natural cycle/rhythm.

How much are you taking?
Pan-colitis and GERD diagnosed May 2003
Osteopenia diagnosed Feb 2006
Status:  Flaring :(
 
30mg pred, Asacol 12 per day,  Azathioprine 100mg, Aciphex, Forvia, and Pro-Bio
 
Co-Mod for the UC forum:  Keep HealingWell running smoothly:  www.healingwell.com/donate


Got2Believe
Regular Member


Date Joined Feb 2007
Total Posts : 436
   Posted 5/13/2008 4:04 PM (GMT -6)   

So what you all are saying is that it makes it harder for my body to make white blood cells and whatever other type of work the immune system does? So i guess prednisone users are more succeptable to diseases?

I read somewhere on healingwell about taking it in the evening i think? its seems better with me b/c I wake up feeling great.


                                                                                         
28/M/TX (revised 5/8/08)
Severe Colitis (pancolitis) since January 9, 2005
currently:  6th week flaring;improving; 2bm/day; no blood!
RX/day:  Currently 10mg of prednisone per day. Lost job and insurance 10/2007 and stopped taking asacol and Imuran cold turkey
OTC: seldom use VSL#3, vitamins & other natural treatments
Diet: SCD helps tremendously, but am not strictly on it.
Other players: food combos, enzymes, good posture, chewing more, etc.


hana24
Regular Member


Date Joined Dec 2007
Total Posts : 354
   Posted 5/13/2008 5:20 PM (GMT -6)   
It does make you more succeptable to diseases - even the enocort says it makes you more succeptable and it is 95% released in your colon. I've always wondered why it makes my IBS symptoms go away also even though they say IBS isn't an inflammation disease.
Jessica 26/F On Entorcout again...
dicyclomine 10Mg before meals/bed
Citalopram 10 MG
Asacol 4pills /three times a day(from 2 pills/ three times a day)
Culturelle once daily
Tried (Entorcort EC 9ml/day and Prednisone)


Got2Believe
Regular Member


Date Joined Feb 2007
Total Posts : 436
   Posted 5/14/2008 3:40 PM (GMT -6)   
OK did a little research on the net. "The exact mechanism of how prednisone works is not known."
Prednisone is a steroid. Steroids help control metabolism, inflamation, immune functioin, salt and water balance, development of sexual characteristics and your ability to withstand stress of illness and injury.
Prednisone is a manmade replica of cortisone, which is produced by our bodies. Our adrenal glands produce the equivalent to 5mg of prednisone per day. Cortisone normally helps regulate the body's salt and water balance and reduces inflamation.
The website i found most of this info from is gihealth.com. Theres a lot more interesting stuff about prednisone that I didn't know so yall might want to check it out.
                                                                                         
28/M/TX (revised 5/8/08)
Severe Colitis (pancolitis) since January 9, 2005
currently:  6th week flaring;improving; 2bm/day; no blood!
RX/day:  Currently 10mg of prednisone per day. Lost job and insurance 10/2007 and stopped taking asacol and Imuran cold turkey
OTC: seldom use VSL#3, vitamins & other natural treatments
Diet: SCD helps tremendously, but am not strictly on it.
Other players: food combos, enzymes, good posture, chewing more, etc.


Katmom
Veteran Member


Date Joined Mar 2008
Total Posts : 609
   Posted 5/15/2008 9:33 PM (GMT -6)   
thank you for your research I have always felt that is was like aspirin...it does a lot, and no one quite understands how it does it. Appreciate the info. Wish we could make it turn off and on like aspirin. My daughter's face is painful to see, though her colon is stalling. Double edged sword.
k
Daughter,14 diagnosed 1-08 w/ UC .learning from you all.
Rowasa, Asacol, Prednizone 50mg, major flare, Hosp. @U of C, Comers. IV steroid, no food, then low residue, home.
Now, began mp6, beginning taper of Pred, now 45mg, horrible acne, moon face, and fearful of future.
trying probiotics, Omega 3, and keeping up with doc visits.


Judy2
Forum Moderator


Date Joined Mar 2003
Total Posts : 8916
   Posted 5/15/2008 10:56 PM (GMT -6)   
I guess if you consider aspirin has been shown to cause Reyes syndrome in children, you might say it's like prednisone. I think of it more like heroin. It makes you feel better quickly, but then you're hooked. You have to keep taking more and more to get less and less effect, and all the while it's gradually destroying your body.
Judy
 
Moderate to severe left-sided UC (21 cm) diagnosed 2001.
Asacol, Rowasa, Pentasa, Prednisone, Entocort, Azathioprine
Avascular necrosis in both shoulders is my "forever" gift from steroid therapy.
Colazal,  Remicade, Nature's Way Primadophilus Reuteri. In remission since April, 2006.
 
Co-Moderator UC Forum
Please remember to consult your health care provider when making health-related decisions.


disco
Regular Member


Date Joined Jan 2008
Total Posts : 154
   Posted 5/16/2008 8:31 AM (GMT -6)   
I've never had to take more pred to get the same effect. i've done 3 cycles in 4 years, every time I start at 40 MGs and cycle down.

The only side effect I ever suffer is some minor acne, usually on my back and shoulders. I also do have some trouble sleeping by as somebody who works full time and goes to grad school I welcome that side effect.

It does make me hungier though but I don't even consider that to be an issue.

Never had the joint pain, mood swings, swelling, or other side effects people seem to complain about.
Diagnosed in spring 2005 at age 28
Currently on 12 asacol pills a day + Entocort
40 MG Pred cycle stating 3/26
Remicade


Styx
Regular Member


Date Joined Jun 2007
Total Posts : 60
   Posted 6/22/2010 8:44 AM (GMT -6)   
Hi,

Let me go a few levels deeper (possibly deeper than you'd like, but if so just ignore me!)

As stated earlier in this forum, we're not exactly sure how corticosteroids work to suppress the human system. Humans are actually a member of the "steroid-resistant" species, meaning the effects we feel are actually substantially less than say, a mouse. In many other species, the introduction of large amounts of steroids leads to massive die off of immune cells, which can be dangerous (and therapeutic if done carefully). In humans, this does not appear to be the case.

Here is what we have observed and believe accounts for the effectiveness of steroids:
1) The activity of basophils and monocytes, two types of white blood cells, are severely depressed while on steroids. While these two subsets of whiteblood cells are few in number, they play an important role in coordinating the immune response. In their suppressed state, the immune system cannot effectively mount a response to antigens. You probably feel this immediately when you take steroids.
2) It has been shown that activated white blood cells are killed by high levels of cortisol (called lysis). You probably feel this immediately when you take steroids as well.
3) After several weeks (~2-4), antibody production is severely depressed (~28% of normal) as corticosteroids turn blood-making marrow into fatty marrow (or at the very least influence the bone marrow in a way that inhibits plasma cell production, and therefore antibody production). This is the "long-term" effect of steroids that you do not feel immediately.

Anyway, this is actually kind of a high-level description from my world :) But I hope it works. Bear in mind these are just the "effects" we've observed from steroids. Whether or not they actually "cause" you to feel better is difficult to say.

Styx
Male Age 24. Diagnosed w/ Crohn's... some wondering if Wegener's Granulomatosis (high PR3). Right now I'm assuming its mild Crohn's. History of HORRIBLE Sinusitis, PND, allergies (very rare allergy to erythromiacin). Currently taking Azathioprine.


thatfield
Veteran Member


Date Joined Jul 2008
Total Posts : 822
   Posted 6/22/2010 10:12 AM (GMT -6)   
hana24 said...
It does make you more succeptable to diseases - even the enocort says it makes you more succeptable and it is 95% released in your colon. I've always wondered why it makes my IBS symptoms go away also even though they say IBS isn't an inflammation disease.

Hi - I do not know about IBS but UC is an inflammation disease.  UC and IBS are not the same thing.  With UC, your immune system is actually attacking healthy cells.  It is a malfunction of the immune system response (triggered by who knows what) that causes your immune system to attack healthy tissues and systems.  This does cause inflammation.  That is why immune suppressing drugs such as pred can help.  These drugs also can help arthritis, asthma, lupus, and all the other varieties of autoimmune diseases.  Pred does decrease your white blood cell count and suppress your immune system.  So do AZA drugs.  Hope this helps!

 
 
Dx 2006 right after the birth of my daughter, currently pregnant with #2!
Lialda 3 pills a day
Rowasa Nightly
Prenatal Vitamins
 

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