Hair Loss and Mesalamine

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Happy Cat
New Member


Date Joined Aug 2008
Total Posts : 13
   Posted 8/8/2008 2:26 AM (GMT -6)   
Quick question: Has anyone had experience with hair loss while on mesalamine either oral meds or enemas?  I am on both Lialda  and Rowasa and have been for awhile. (I was on Asacol for many years but changed to Lialda about 4 months ago.) I am noticing a thinning of my hair and presence of more hair on my comb and brush.  I read that this can be a side effect of mesalamine.  Not sure if it is common or rare or how bad it gets if it is indeed really occurring.  Many thanks.
 
diagnosed with UC (proctitis to 15 cm) August 2001
4 tablets daily of Lialda 1.2g
1 Rowasa enema nightly
62, married female

kazygirl
Veteran Member


Date Joined Sep 2007
Total Posts : 955
   Posted 8/8/2008 2:38 AM (GMT -6)   
i have not had hair loss that i am aware of from mesalasine.
been on it for almost 2 years
steph - 32 - female - UC since 2000
currently flaring again..  grrr! (triggered by stress - grrr)
mesalazine granules 3g x1 a day (much nicer than a million tablets a day)
enteric coated fish oil -omega 3 (so they get all the way to my colon)
vitamin D3 x1 a day
prednisolone 25mg x1 a day (ick ick and did i say ick?)
tumeric capsules x3 a day
 
 
 


quincy
Elite Member


Date Joined May 2003
Total Posts : 25163
   Posted 8/8/2008 10:35 AM (GMT -6)   
It's one of the side effects that a few have complained about. Some, however, were on Prednisone beforehand...

There are other meds that can also cause hairloss...meds for cholesterol or high blood pressure..as well as being past menopause or low or high thyroid.

Definitely get checked out for thyroid and I suggest you make sure you take B complex.

I do go through periods where it seems I'm losing more hair than normal (about 100 hair daily is the norm)...but my hair is longer at this time and I'm noticing it more. It could also be this time of the year or I'm in a phase of having more hair falling out because of time of year..etc.

I've been on 5ASA meds for over 19 years, and with age, I've noticed some change in the amount of hair I have...but I wouldn't say I'm losing hair.

Do you wash it regularly? brush it regularly?

quincy
*Heather*Status: mini flare Dec 28... tapered to every 4th night
~diagnosed January 1989 UC (proctosigmoiditis)
~5ASA: Asacol (6 daily) + Salofalk enemas (increase for flares tapered to maintenance)
~Bentylol (dicyclomine) 20mg as needed
~vitamins/minerals/supplements 
~Probiotic 3(Natural Factors Protec) bedtime + 1 (Primadophilus Reuteri) occasionally
~multi-digestive enzymes as needed ....zymactive 3 - 5x daily
~Ranitidine,Pariet (reflux) Effexor XR 75mg;  Pulmicort/Airomir (asthma)
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS"  worth it !!!


munchkindd
Regular Member


Date Joined Oct 2007
Total Posts : 348
   Posted 8/8/2008 10:44 AM (GMT -6)   
I've noticed my hair thinning now for many, many years. I don't think it is from the mesalamine because for many years I wasn't on any meds and it was still going on. Perhaps it's another wonderful thing that just comes along with UC??
*******Donna*******
 
diagnosed with uc 27 years ago.  Enojoyed 20 year remission with just minor blips here and there (approximately 16 of those years without any meds)
 
In a flare for 2 very long years which Asacol didn't help at all.  Finally in remission again since Jan 2008, can't believe it..............
 
currently on Sulfasalazine 2 tabs 3x day. Folic acid, mesalamine enema once a week. Omega 3, Probiotics, multi vitamin, calcium supplement, Biotin 5000mcg, Fibercon.
 


quincy
Elite Member


Date Joined May 2003
Total Posts : 25163
   Posted 8/8/2008 10:48 AM (GMT -6)   
malnutrition or lacking or sudden change in certain vitamins and hormones will cause hairloss. Of course, there is an autoimmune hairloss..where the body attacks the hair in the follicle.

q
*Heather*Status: mini flare Dec 28... tapered to every 4th night
~diagnosed January 1989 UC (proctosigmoiditis)
~5ASA: Asacol (6 daily) + Salofalk enemas (increase for flares tapered to maintenance)
~Bentylol (dicyclomine) 20mg as needed
~vitamins/minerals/supplements 
~Probiotic 3(Natural Factors Protec) bedtime + 1 (Primadophilus Reuteri) occasionally
~multi-digestive enzymes as needed ....zymactive 3 - 5x daily
~Ranitidine,Pariet (reflux) Effexor XR 75mg;  Pulmicort/Airomir (asthma)
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS"  worth it !!!


Happy Cat
New Member


Date Joined Aug 2008
Total Posts : 13
   Posted 8/8/2008 12:12 PM (GMT -6)   
It could be the hair loss is an age-related thing.  It is not a huge amount or really noticeable --- just a new area where a patch on one side seems lots thinner. Maybe it is just age (62) also something one doesn't want to consider as well.

potato
Regular Member


Date Joined Jun 2008
Total Posts : 281
   Posted 8/8/2008 12:45 PM (GMT -6)   

I wondered about this a few weeks back, too, but my mesalamine is Asacol.  I definitely think that there is a relationship between hair loss and mesalamine, and maybe yours was triggered by the change in your meds. 

But, I also think there are probably other factors involved, like lack of protein, hormone shifts (as quincy mentioned, thyroid, for example), and other nutritional changes that occur when you switch meds.  There are so many factors that could apply.

My best reassurance was from my hair dresser, who told me that I had no bald patches and tons of little hairs growing back in.  They're also growing in thicker and curlier.  What a relief!  You might check with your hairdresser.

  


Potato...  Female, 58, dx mild left sided ulcerative colitis 11/07
asacol 3 3x a day  
culturelle, citracell
children's vitamin, Vitamin E 400 mg
omeprazole 2x a day
oxazepam (anti anxiety) when needed
 
 
 
 
 
 


Scrap Girl
Veteran Member


Date Joined Jan 2007
Total Posts : 653
   Posted 8/8/2008 12:46 PM (GMT -6)   
I had major hair loss from Asacol. I switched to Colazal and it stopped. You might try Biotin 5000, available at most drug stores. I've had hair loss on and off from different medications and that seems to help a lot. The lower dosage of Biotin didn't do anything for me. Good luck.
Diagnosed with UC in Feb. 2005
 
Colazal (9 a day)
Folic Acid
Biotin
Calcium
Remicade


libby22
New Member


Date Joined Apr 2008
Total Posts : 14
   Posted 8/8/2008 5:15 PM (GMT -6)   
I take Canasa once per day as my only UP med and have also noticed hair loss, I'm glad you posted on this! Been taking it for about 3 months & I'm shedding like crazy.
Diagnosed with Ulcerative Proctitis with cecum ulcer 4/08
Currently on Canasa 1000 once per day
Plus potassium supplements and citrucel daily
Discontinued Lialda and Colazal due to rashes
Sulfa allergy


WindsofCreation
Regular Member


Date Joined Feb 2008
Total Posts : 30
   Posted 8/8/2008 10:32 PM (GMT -6)   
Ok....I've noticed tons of hair falling out while i was on asacol. I then switched to lialda....no difference. Now I'm on Colazal and still losing hair. I'm only taking 4 a day. I've made SEVERAL posts about this topic...no one really knows what's going on. I've been led to believe it IS the colazal that's making my hair fall out.I've gotten everything checked out(blood tests,thyroid ect.) I take biotin,multi-vitamin,folic acid. I am not lacking any vitamins. No one in my family or extended family is bald ( I am only 23) ????????I HAVEN'T TAKEN PRED IN OVER 2 YEARS. I haven't had any symptoms in 2 years either. Remission! This makes no sense!

SunnyFlorida
Regular Member


Date Joined Mar 2008
Total Posts : 43
   Posted 8/9/2008 5:15 PM (GMT -6)   
I am also currently going through hair loss, which has lasted about five weeks so far.  I pretty much can pull it out by the handful after washing my hair.  I am waiting on blood tests to see if that might shed some light.  If all of your tests checked out, could it be something you have done to your hair lately, like getting a perm?  I got a perm about two weeks before my hair started falling out, and my scalp is still very sore after all of this time (like when you wear your hair differently than the way it naturally falls).  I have read that could be due to scarring from the perm solution.  I have also read that hair tends to fall out three to four months after you have had an illness.  Were you sick a few months back?

~~~~~Teresa~~~~~
 
Diagnosed with UC in 1997
Asacol 400 2 x 3 daily
Mesalamine liquid 60 ml once daily
 


quincy
Elite Member


Date Joined May 2003
Total Posts : 25163
   Posted 8/9/2008 5:54 PM (GMT -6)   
Teresa...The perm could have caused some breakage from the elastic being too tight or from the hair being in a weaker state than assumed by your hairstylist and broken off at the scalp from the perm solution.

If your scalp is really sore, it could be a sensitivity to the particular perm solution. Do you have any sores on your scalp?

Defiitely tell your hairdresser so that she/he can make changes to use a different and more mild perm.

q
*Heather*Status: mini flare Dec 28... tapered to every 4th night
~diagnosed January 1989 UC (proctosigmoiditis)
~5ASA: Asacol (6 daily) + Salofalk enemas (increase for flares tapered to maintenance)
~Bentylol (dicyclomine) 20mg as needed
~vitamins/minerals/supplements 
~Probiotic 3(Natural Factors Protec) bedtime + 1 (Primadophilus Reuteri) occasionally
~multi-digestive enzymes as needed ....zymactive 3 - 5x daily
~Ranitidine,Pariet (reflux) Effexor XR 75mg;  Pulmicort/Airomir (asthma)
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS"  worth it !!!


SunnyFlorida
Regular Member


Date Joined Mar 2008
Total Posts : 43
   Posted 8/10/2008 7:17 PM (GMT -6)   
Thanks, quincy!  I will definitely find out what perm solution was used.  No sores--but according to my husband, no new hair growing, either.  I will probably take a long vacation from getting my hair permed at all.

~~~~~Teresa~~~~~
 
Diagnosed with UC in 1997
Asacol 400 2 x 3 daily
Mesalamine liquid 60 ml once daily
 


Old Hat
Veteran Member


Date Joined Feb 2007
Total Posts : 4414
   Posted 8/12/2008 7:19 PM (GMT -6)   
One should beware of perms + use a mild shampoo. I notice loss of more hair while on higher doses of Colazal; even 1 capsule more daily seems to make a difference. It's likely, too, that the drop in estrogen levels that women experience by their later 50s affects hair loss & regrowth. Some of it could even be evolutionary: distancing ourselves from other (hairier) primates! / Old Hat (nearly 30 yrs with left-sided UC; currently on 3 Colazal daily for maintenance of remission)

UChick
Regular Member


Date Joined Jun 2006
Total Posts : 157
   Posted 8/12/2008 9:29 PM (GMT -6)   
I take Asacol and I've never had any hair loss problems.
Age 18
Diagnosed September '01 : Remission since July '02
Asacol- 4 pills 3xday
Azathioprine- 75mg 1xmorning
Centrium A-Z multi-vitamin
Took Remicade 3 times, BIG FAN!!!!
Have Taken: Prednisone, Flagyl, Zantac (for acid reflex)


SunnyFlorida
Regular Member


Date Joined Mar 2008
Total Posts : 43
   Posted 8/13/2008 10:08 AM (GMT -6)   
I just refilled my prescription for mesalamine enemas (same thing as Asacol pills--different form--and Rowasa enemas), and one of the possible side effects listed is hair loss.  I've been using mesalamine for eleven years, and never had this side effect.  Can side effects change after using it all of this time?

~~~~~Teresa~~~~~
 
Diagnosed with UC in 1997
Asacol 400 2 x 3 daily
Mesalamine liquid 60 ml once daily
 


mom3boys
New Member


Date Joined Aug 2008
Total Posts : 1
   Posted 8/13/2008 7:01 PM (GMT -6)   
I just realized my hair loss is due to Lialda--mesalamine.  I went on it in April, 2008 and have always had thick curly wild hair so it took awhile to realize, but it is now very thin, bad texture and I probably lost half my hair.  Blood tests recently taken were all fine.  Since I have never had this problem, am 47, just started taking Lialda and my doctor had an oh my goodness look when I told him of this side effect and told me to go to 2 tablet instead of 4, all signs indicate it is the Lialda.  I have been on 2 tablets for 3 weeks and it doesn't seem like I am losing as much, but my hair isn't getting any thicker or looking any better considering I am eating alot of protein and taking alot of vitamins.  So for some of us the lialda is the reason for the hair loss.

FitzyK23
Veteran Member


Date Joined May 2005
Total Posts : 4218
   Posted 8/13/2008 7:18 PM (GMT -6)   
I think pentasa is the cause of my hair loss. I saw a derm and am now starting rogaine to try to stop the hairloss. He said I should only need it for 6 month or so to over ride whatever messages my body is getting from the crohns pills. I am also taking Yaz birth control which he said would help in about 3 months. I try to remember to take biotin too.
26 Year old married female law student (last year!!). Diagnosed w/ CD 4 years ago, IBS for over 10 years before that, which was probably the CD. I am sort of lactose intollerant too but can handle anything cultured and do well w/ lactose pills and lactaid. For crohns I am currently on Pentasa 4 pills/4x day and hysociamine prn. I also have bad acid reflux and have been on PPI's since age 13. I have been through prilosec, prevacid, and nexium. Currently I am on Protonix in the morning and Zantac at night. I also take a birth control pill to allow some fun in my life.


quincy
Elite Member


Date Joined May 2003
Total Posts : 25163
   Posted 8/14/2008 12:35 AM (GMT -6)   
Hair regrowth will take about 3 - 4 months to start showing at the scalp....consider it grows about a half inch a month, so your other hair won't be thicker unless you use some products that can enhance it.

q
*Heather*Status: mini flare Dec 28... tapered to every 4th night
~diagnosed January 1989 UC (proctosigmoiditis)
~5ASA: Asacol (6 daily) + Salofalk enemas (increase for flares tapered to maintenance)
~Bentylol (dicyclomine) 20mg as needed
~vitamins/minerals/supplements 
~Probiotic 3(Natural Factors Protec) bedtime + 1 (Primadophilus Reuteri) occasionally
~multi-digestive enzymes as needed ....zymactive 3 - 5x daily
~Ranitidine,Pariet (reflux) Effexor XR 75mg;  Pulmicort/Airomir (asthma)
~URSO for PSC (or PBC) 500mg X 2 daily (LFTs back to NORMAL!!)
My doc's logic.. "TREAT (FROM)BOTH ENDS"  worth it !!!


FitzyK23
Veteran Member


Date Joined May 2005
Total Posts : 4218
   Posted 8/14/2008 7:19 AM (GMT -6)   
Thanks quincy. I had SUPER thick hair to begin with and now just have slightly thin hair. Our goal is more to prevent further loss than to actually see regrowth. Regrowth would be a bonus but I am just trying to put a stop to the loss. I used it for the first time today and it made where I used it a bit sticky. The rest of my hair feels really dry and parched today. I can't find my hair straightener which usually smooths it all out. I think I left it at my parents house. Grrr.
26 Year old married female law student (last year!!). Diagnosed w/ CD 4 years ago, IBS for over 10 years before that, which was probably the CD. I am sort of lactose intollerant too but can handle anything cultured and do well w/ lactose pills and lactaid. For crohns I am currently on Pentasa 4 pills/4x day and hysociamine prn. I also have bad acid reflux and have been on PPI's since age 13. I have been through prilosec, prevacid, and nexium. Currently I am on Protonix in the morning and Zantac at night. I also take a birth control pill to allow some fun in my life.


What A Life
Regular Member


Date Joined Mar 2010
Total Posts : 116
   Posted 4/27/2010 6:48 AM (GMT -6)   
I officially am losing hair from Pentasa now... Guess I need to start a Rogaine regimen? I was under the impression that once you started rogaine you couldn't stop using it though as the new "regrowth" would fall out... Any truth to this? Anybody try Propecia?
28 Y/O Male DXed Crohns in 2000.
Fistulotomy/Fistulectomy 2001
Been on many meds including Remicade.
Asacol and Pentasa on a when-needed basis as of recent
Current regimen: Diet and Exercise.


Indigo69
Regular Member


Date Joined Feb 2013
Total Posts : 58
   Posted 5/9/2013 3:05 PM (GMT -6)   
Hi there, I started originally on pentasa suppositories and noticed rapid hair loss ! I literally woke one morning to a patch of hair missing from my front and it went down hill from then on. Still never recovered hair in thst spot. And now on salafolk (asacol) & all the hair around my temple area and sides hslf thickness of what it was and seems the only part of my hair not egfected is hair directly on my head :-( I had super thick beautiful hair but now I look like an old man. There is a link for sure !
Diagnosed 2012 - Nil remission achieved
Maintenance - Salafolk (Asacol) 7Tabs in Morn
On and Off Prednisone - 30mg + taper
3 x Probiotic Daily
3 x 1000mg Cranberry
1 x 1000mg Calcium
1 x Vit C
Prescribed B12 + Folic Acid
B12 Shot every 3mnths
Low Iron borderline Anemia
Lactose intolerant since diagnoses / G-Free diet
Nil tolerance to spicy foods / Alcohol

protocolteck
Regular Member


Date Joined Mar 2013
Total Posts : 338
   Posted 5/9/2013 3:12 PM (GMT -6)   
Mesalamine absolutely causes hair loss-in fact, it says it on the drug insert for Canasa (Mesalamine sups). Also, My GI said all Mesalamine can cause hair loss, sometimes short term, sometimes long term. Unfortunately, I have lost a great deal due to this :-(
Male, 45
No UC meds
VSL#3 2/day
SF/Spinach Diet started 3/11/2013. Added Resistant Starch 4/14/2013.
Ulcerative Proctitis since 2/2012
Remission since early April, 2013
Gluten Free since 12/1/2012-went into remission for 1 month going GF then symptoms returned on 1/1/2013. I still remain GF for other reasons.
Mountain Runner and Level 1 Crossfit Athlete
Sodium Butyrate
Vitamin E Suppositories

mscc
New Member


Date Joined Apr 2014
Total Posts : 1
   Posted 4/16/2014 6:42 PM (GMT -6)   
I have been diagnosed with lichen planopilaris, permanent scarring hair loss. I believe that it is from taking Lialda. What I am a little upset about is the fact that the Lialda Literature states that "hair loss" or "thinning" could be a side effect of the drug. Why not say "permanent scarring hair loss" or the disease "lichen planopilaris" is a possible side effect? This is a whole different ball game than simple hair loss. A bald head on a man might be sexy, but not on me.
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