Is prednisone withdrawal or use of imuran causing joint pain?

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Banjonut
New Member


Date Joined Jul 2008
Total Posts : 12
   Posted 8/10/2008 10:48 AM (GMT -7)   
I am in remission from Crohns and have changed my meds over the past 2 months.  It has caused me severe and disabling joint pain.  I simply cannot function without pain medication.  All of my joints from my toes, feet, ankles, knees, hips, shoulders, elbows, wrists and fingers are affected!  My Gas. Dr told me that he didn't think it was the withdrawal from prednisone or continued use of Imuran that was causing the problem based on the fact that he had never seen anyone with symptoms as severe as mine from either of those.
 
Personally, at first I thought it might be a side effect of the Imuran that I continued to take after the Prednisone.  (I have been off Prednisone for 6 weeks after being on 30mg/day for 10 months.)  I thought the prednisone was simply hiding the side effects of the Imuran.  So with my Dr's instructions, we stopped the Imuran a week ago to see if the joint pain would stop.  It has not stopped.
 
Now I am wondering if my joint pain is being caused by withdrawal from the Prednisone and not the Imuran.
 
I am 57 and was only diagnosed with Crohns 2 years ago.  I want to continue working until I am 62, but I don't think I can make it if this joint pain continues.  I have to take a vicodin every four hours and even then it hurts to walk or get in/out of a chair.  Without a pain pill I have to stay in bed and bear the pain even then.
 
Has anyone else experienced anything like this?  The only other drug I am taking is Asacol.  But, I have been taking that since the onset of Crohns two years ago and it never seemed to give me any problems.  Which most likely to be causing my joint pain, the prednisone withdrawal or the use of Imuran without the Prednisone?
 
 

suebear
Forum Moderator


Date Joined Feb 2006
Total Posts : 5429
   Posted 8/10/2008 11:08 AM (GMT -7)   

My guess is prednisone is the culpirt.  I was on varying doses; 10mg-40mg for over 2 years.  Mostly I was on the low dose side.  After surgery I tapered off 10mg and had raging joint pain for about one full year.  I just buckled down and grinned and got through.  By then I was OVER taking drugs (had been on 22-25 pills per day for UC) and refused to take anything else.  Most likely this pain will go away but it might take time.

Sue


dx proctitis in 1987
dx UC in 1991, was stable until 1998

1998 started prednisone, asacol, pentasa, nortriptylene, ativan, 6MP, rowasa enemas and suppositories, hydrocortisone enemas, tried the SCD diet, being a vegetarian, omega 3s, flax, pranic healing, yoga, acupuncture, probiotics

2000 lost all my B-12 stores and became anemic

2001 opted for j-pouch surgery- now living life med-free


suebear
Forum Moderator


Date Joined Feb 2006
Total Posts : 5429
   Posted 8/10/2008 11:10 AM (GMT -7)   

Oh, you might want to see a specialist (rhuematologist) if this continues at this severity as it could be arthritis.  We IBDers are more prone to chronic inflammatory joint pain.  If that's the case the rhuematologist can get you on a better non-narcotic to manage the symptoms.

Sue


dx proctitis in 1987
dx UC in 1991, was stable until 1998

1998 started prednisone, asacol, pentasa, nortriptylene, ativan, 6MP, rowasa enemas and suppositories, hydrocortisone enemas, tried the SCD diet, being a vegetarian, omega 3s, flax, pranic healing, yoga, acupuncture, probiotics

2000 lost all my B-12 stores and became anemic

2001 opted for j-pouch surgery- now living life med-free


Banjonut
New Member


Date Joined Jul 2008
Total Posts : 12
   Posted 8/10/2008 3:33 PM (GMT -7)   
Thanks Sue.  After reading much online about this, it could very well be the fact that I am no longer on the prednisone.  I was weaned off of it properly.  I had my daily dosage decreased by 2.5mg per week until I went from 30mg/day to nothing.  My joing problems became a problem when I got down to below 10mg/day.  The level of pain/stiffness has stayed he same for the past 6 weeks being completely off the prednisone.  (It is less and tolerable when I take either vicodin or darvocet)  I tried taking tramadol (ultram), but it was like taking a couple of tylenol.  It had virtually no effect, so I abandoned it after just a 3 day trial.
 
I'll see what the rheumatologist has to say a few weeks from now if the pain hasn't subsided or gone away by then.
 

SunnyFlorida
Regular Member


Date Joined Mar 2008
Total Posts : 43
   Posted 8/10/2008 7:08 PM (GMT -7)   
I too am experiencing a lot of pain in most of my joints after coming off of Pred about three months ago.  The pain has not lessened, so I have had bloodwork done and am waiting for the results to see if it might be arthritis.  Definitely look into getting some blood tests done if it persists.

~~~~~Teresa~~~~~
 
Diagnosed with UC in 1997
Asacol 400 2 x 3 daily
Mesalamine liquid 60 ml once daily
 


Another UC wife
Veteran Member


Date Joined Jun 2007
Total Posts : 2111
   Posted 8/10/2008 10:51 PM (GMT -7)   
Hubby came off prednisone in Dec. and he suffered with joint pain primarily in his shoulders and hips. I too was wondering if it was the azathioprine that was increased from 75 to 150 mg in Nov. One month later the tapering schedule of the prednisone had him off it finally. The Dr insisted it was not the aza. and the prednisone was probably it and it would go away eventually. He started in August on the fosamax so we were thinking maybe that was that contributing to it.

Add to that his primary care upped his zocor from 20 to 40 mg and then wham....very debilitating joint pain. We stopped the fosamax as our research made us think that was doing it. No change. The Mayo Dr's guess was the increase of the statin drug which made sense. So he went back to the 20 mg of zocor and back on the fosamax....within a month the hip pain was gone and his shoulders are doing much better.

So 8 months after coming off the prednisone and cutting back to the 20 mg of zocor he has been on for about 7 years with no ill effects and things are much better. So I have to agree that the prednisone's effects that can take up to a year I hear to completely leave your system was the main culprit. Changing his zocor really complicated & compromised things further.

Hubby also got a very bad case of roseacea and the Mayo Dr. assured us that it would go away in time after he was off the prednisone and it certainly did.

Suffice to say the darn prednisone wreaks havoc.

Hubby is still on a pain management program for the colitis but things are looking up and he is having better days so I am hoping that weaning of the pain meds will be starting soon. Even with those pain meds the joint pain was very debilitating as you are reporting.

It's easy for others to say hang in there and it will get better or should with time but every day you are in that kind of pain is very tough to deal with. As suggested above maybe your Dr can have you checked or tested to be sure it is not something else that needs additional treatment.

I hope it is the prednisone withdrawal and you start to feel better sooner than later.

61 yr old male~Colitis 1st diagnosed Jan '05-cleared up within a few wks. Flared again in May '06 (now UC) & hospitalized 5/07-currently heading towards a remission. Osteopena of spine from prednisone DX 8/07  Oct 07 feeling quite normal most days.  150mg Imuran  Zero mg prednisone  12 Asacol, Lidocaine Hydrochloride Jelly 2%,multi vitamin, iron 1X day, DanActive, chewable calcium, fiber capsule 1x day, Prilosec 20mg, enalapril 10mg, glipizide 5 mg, zocor 20 mg, baby aspirin, (Fentanyl pain patch 50mg 72 hrs  Morphine Sulf 15 mg twice daily)Cortifoam enema every other PM, Canasa suppositiry AM, folic acid 1mg, Fosamax 1x month


Luna0
Regular Member


Date Joined Jul 2008
Total Posts : 83
   Posted 8/10/2008 11:04 PM (GMT -7)   
Tell ya what if the docs ever find a better drug then prednisone. I would be taking that instead. No really I googled it and it poped up with at least 3 pages.

I HATE PREDNISONE!!!! Ahh that felt good to yell out.
Good thing I am now off of it. The side effects were making me go mad.
Tawn 
18 years old, College Student ~WAHOO GO CATS=)
 
Diagnosed in 2004
Currently on:
Remicade
Imuran 3pills/day
And many other over the counter meds.


yuckygut
Regular Member


Date Joined Feb 2008
Total Posts : 214
   Posted 8/11/2008 4:33 PM (GMT -7)   
As everyone here knows, prednisone is a potent anti inflammatory, that is why it is so beneficial to so many inflammatory based disease processes. But as luna said above, I think most everyone hates it because of its horrible side effects. It would make sense that some individuals coming off their prednisone would develop joint pain, I wonder if trying Haldi drinks would give you relief as it is anti inflammatory?? They allowed me to come off all my UC and GERD meds and I have now been in remission for going on 2 years. The other option may be going on other pain meds, or back on steroids, good luck and I hope you find the right treatment to help you.

--------------------------------------------------------

yuckygut

diagnosed 1998

now off prednisone and colazal

drink 1 Haldi daily

Socalsd
Regular Member


Date Joined Jul 2008
Total Posts : 100
   Posted 8/11/2008 4:39 PM (GMT -7)   
banjonut,

I think it is the Prednisone. I am 33 and never get joint pain unless I am on it. I am currently tapering to 30mg a day from 40. Strangely I get the most pain in my toes for some reason. It only happens around the times I have used Prednisone.
Prednisone 35 mg a day
Asacol 400mg 4 pills 3 times a day
Mesalamine enima
VSL #3 probiotic


Beth75
Veteran Member


Date Joined Jul 2007
Total Posts : 2142
   Posted 8/12/2008 9:03 AM (GMT -7)   
my last pred taper, I had severe pain @ 5mg in my feet and knees, very hard for me to walk and climb stairs but once I got going would be ok. I just got down to 10mg again and am not looking forward to the pain again.

Beth, 32 ~ hoping to taper pred successfully, wish me luck!
Major Flare Sept/Oct 07
UC dx'd 03/00 (Proctosigmoiditis); Pancolitis since 09/07
Azathioprine 200mg 1xday nightly; Calcium and Vit D 500mg 3xday, Multi Vit, Folic Acid 400mg 2xday, Prilosec, Probiotics.
Minimal Change Disease (Kidney Disorder) dx'd 09/07 - partial remission since 03/08
Prednisone 15mg 1xday, Simvastatin 20mg 1xday, Diovan 160mg 2xday. Tekturna 300mg 1xday, Fosomax 70mg 1xweek. MCD may be from hypersensitivty to 5ASA drugs.  Do you have edema? If so, check your blood protien level!
 


Supa
Veteran Member


Date Joined Jul 2008
Total Posts : 748
   Posted 8/20/2008 12:15 PM (GMT -7)   
I am so glad to see this thread!  I am down to 5mg/day (I really need to update my signature) and will be dropping down to 2.5mg tomorrow for my last week on the pred.  The last couple of days have been torture with all of the joint pain!!  Before going on the pred (in April of this year), I had never had issues with my joints at all. 
 
I am hoping it is just related to the predinisone withdrawl for all of us dealing with it.  (for the record, the other things I am on are asacol and I am in the Humira trial, though I don't know for sure that I am getting the drug-I think I am though)
 
I will be seeing my acupuncturist tomorrow, and this is definitely going to be what I ask her to focus on.  It is hard to do anything, and I feel like I am an old woman rather than a 33year old.
Laura
 
33 years old, stay at home mom of 2 girls, ages 3 and 21 months
 
Diagnosed in 2007
Currently on:
Prednisone 12.5mg/day and tapering-UGH
Asacol 6pills/day
Biweekly injections for Humira clinical trial-going well so far!!


SunnyFlorida
Regular Member


Date Joined Mar 2008
Total Posts : 43
   Posted 8/20/2008 12:57 PM (GMT -7)   
My blood tests all came back normal--no rhuematoid arthritis.  My joint pain has finally started to lessen during the past two weeks.  I definitely think my body is still adjusting to going off of the Prednisone.  In my experience, the longer I have to take Pred, the longer the side effects take to subside after going off of it.  Excercise, believe it or not, has helped the joint pain tremendously.  Hopefully you will feel better soon--hang in there!

~~~~~Teresa~~~~~
 
Diagnosed with UC in 1997
Asacol 400 2 x 3 daily
Mesalamine liquid 60 ml once daily
 


jcarroll01
Regular Member


Date Joined Jun 2006
Total Posts : 39
   Posted 8/20/2008 2:31 PM (GMT -7)   

I might be in the minority here, but I had two bad reactions to the introduction of Immuran. The first time I was put on it it took two weeks until I was hospitalized with debilitating kee pain (couldn't take one step). I also had crazy liver enzyme levels and other issues. The Dr. told me that if he didn't know better he would have guessed I was dying of liver failure...They dosed me with IV steroids and released me 2 days later. In an amazing leap of faith...I took another Dr.s advice that the Immuran couldn't possibly be the culprit and started again. You guessed it....10 days in and I was bedridden and all the same blood tests showed a liver out of control.

Who knows? Everyone has different reactions to medication...Good luck.

 

 

 


Diagnosed 2004 - mild throughout
 
Reactive to 5-ASA drugs and apparently Immuran...argh
 
Currently - no meds and no problems...go figure.


UMDTerp2001
Regular Member


Date Joined Sep 2006
Total Posts : 246
   Posted 8/20/2008 4:33 PM (GMT -7)   
I had horrible horrible horrible joint pain during the prednisone taper process in my shoulder, toes, hips, etc etc. Luckily it all went away albeit slowly after I got better and got off the prednisone. Hopefully, you'll get better too once you're in a good remission and get off the prednisone. 10 months at that dose seems like a long time with such a powerful drug, (although) i'm sure it helped your symptoms. I think you'll improve if you can get healthy. It's most likely the pred and you will get better and make it to your goal so keep your head up and keep pushing yourself to get out of bed each day and stay with your routine.
 
 
__________________________________________________________________________________
- 30 y/o male residing in Northern Virginia living a fairly "normal" life at the moment
- Currently in remission
- Pancolitis since April, 2006
- Small fistula and anemic at times 
- 4 Colazal/day, multivitamin, Fish oil and Primal Defense Probiotics 2x/day
 
 


pb4
Elite Member


Date Joined Feb 2004
Total Posts : 18186
   Posted 8/20/2008 5:27 PM (GMT -7)   
Actually your joint pain could be from extraintestinal manifestations of crohn's (IBD) and not necessarily from any of the meds, it could be coincidence that it started after you took either med, it very well could have come on regardless...best to see a specialist about your joint pain though and hopefully they can find a way to help ease things for you...bad enough having IBD.

:)
My bum is broken....there's a big crack down the middle of it! LOL :)


twirliegirl
New Member


Date Joined Sep 2007
Total Posts : 14
   Posted 8/22/2008 11:25 AM (GMT -7)   

Hello, Everyone,

I too had horrible joint pain for 8 weeks after quitting prednisone. Prior to that I had to be taken off of Imuran because I came in contact with the shingles virus. During that time being off Pred and imuran my joint pain was unbearable.  I am now back on Imuran after receiving the shingle virus vaccine. This has just been a few days ago, so the Imuran has not had time to get in my system. As for the point pain now it is amazing, after being put back on predisone 20 mg a day until the imuan takes hold, my joint pain is absolutly gone. I ask my GI about that, because i came back from looking like an invalid to a healthy normal person.  My GI told me that my joint pain was not due to the predisone, but due to the disease and that was just part of it especially if you are in a flair. Sometimes he says it is a signal that you are going into a flair or you are in one.  All I know when I am not in a flair, I do not have joint pain. It's amazing how this disease affect people differently. God Bless you All.

 

Current meds: Imuran 20 mg, Colazal 3- 3X a day, Canassa 1 a day, Rowasa - nightly

Prednisone 20Mg (until Imuran kicks in)


barnsbury
Regular Member


Date Joined Jan 2006
Total Posts : 443
   Posted 8/23/2008 6:32 AM (GMT -7)   

Sorry to hear what awful pain you are in Banjonut. It sounds like a nightmare.

I am now down to 1.5mg of Pred, tapered down from 40mg. I have been on Pred for 4 years and each time I have tapered, I have got severe joint pain - mostly in my knees.  I have been on Imuran for 8 years and I have never had any joint pain from being on that.

So, I would say for sure it is the pred taper that is causing some, if not most of your joint pain.

Unfortunately, there is not much you can do except grin and bear it. And take painkillers when you need to move around.  I still went to work during my taper and even though I was only 4 mins walk to the metro station, I had to start taking painkillers at my desk an hour beforehand, so I could manage the walk there! What horrible memories.

Hang in there, it will get better.

Best wishes.


Abatacept Trial since Feb 2008 (Maintenance Period)
Back on Pred - 3mg - Steroid Dependent :-(
Azathioprine 150mg
Colazide x3
Actonel 35mg, EPA Fish Oils
Predfoam Enema - Had to stop as not allowed during trial
Asacol x 9, Lialda (Mezavant)
Remicade every 8 weeks  (Stopped working)
Aloe Vera Lily of the Desert Juice  Gave me the worst D !
Primadophilus Reuteri Probiotic
 


Jayhawk2
New Member


Date Joined Sep 2008
Total Posts : 1
   Posted 9/2/2008 8:36 AM (GMT -7)   
Banjonut said...
I am in remission from Crohns and have changed my meds over the past 2 months.  It has caused me severe and disabling joint pain.  I simply cannot function without pain medication.  All of my joints from my toes, feet, ankles, knees, hips, shoulders, elbows, wrists and fingers are affected!  My Gas. Dr told me that he didn't think it was the withdrawal from prednisone or continued use of Imuran that was causing the problem based on the fact that he had never seen anyone with symptoms as severe as mine from either of those.
 
Personally, at first I thought it might be a side effect of the Imuran that I continued to take after the Prednisone.  (I have been off Prednisone for 6 weeks after being on 30mg/day for 10 months.)  I thought the prednisone was simply hiding the side effects of the Imuran.  So with my Dr's instructions, we stopped the Imuran a week ago to see if the joint pain would stop.  It has not stopped.
 
Now I am wondering if my joint pain is being caused by withdrawal from the Prednisone and not the Imuran.
 
I am 57 and was only diagnosed with Crohns 2 years ago.  I want to continue working until I am 62, but I don't think I can make it if this joint pain continues.  I have to take a vicodin every four hours and even then it hurts to walk or get in/out of a chair.  Without a pain pill I have to stay in bed and bear the pain even then.
 
Has anyone else experienced anything like this?  The only other drug I am taking is Asacol.  But, I have been taking that since the onset of Crohns two years ago and it never seemed to give me any problems.  Which most likely to be causing my joint pain, the prednisone withdrawal or the use of Imuran without the Prednisone?
 
 
Banjonut - My GI put me on Prednisone for two months while at the same time on Imuran.  As soon as I stopped the Prednisone I noticed my joints hurt more than ever but assumed it was because the Prednisone made me feel better and helped my arthritis.  After continuing on the Imuran for two more months and having increasing joint pain, muscle weakness and swelling of my legs and feet (primary doctor gave me water pills for that) my GI doctor told me to quit the Imuran.  Now I'm just on Colazal 3 x 3 a day and Ultram 3 x day.  The Imuran helped the ulcerative colitis but my side effects are three of the "rare" side effects of this drug and I will not be able to take it. 
 
I still have lots of joint pain like you describe and to the point of tears.  I am thinking that it will take at least four months for the Imuran to clear my system since that's how long I have been on it.  I don't see my GI doctor until the end of November and just pray that things will get better as the Imuran leaves my system.  I really don't think the problem is with the Prednisone withdrawal but with the Imuran. 
 
Jayhawk
 

NatWell
Regular Member


Date Joined Dec 2010
Total Posts : 101
   Posted 3/9/2011 7:55 AM (GMT -7)   
I have severe UC and was given the IV big dose of prednisone in the hospital 120mg, 60 each 12 hours.  I got a massive headache, for sure a migraine, in the hospital.  Never had a migraine before but I couldn't walk or be near any light.  I took migraine med and it went away after about an hour with a dull pounding after that.  Now it comes out of nowhere without warning.  I am at home on 40mg prednisone.  I also started imuron 3 weeks ago and had remacaide infusion in the hospital.   Anyone else get migraines that has never had them before after using any of these drugs?  I never had headaches on prednisone before or coming off of it.  The only new drug in the mix is imuron. 

subdued
Veteran Member


Date Joined Dec 2008
Total Posts : 3231
   Posted 3/9/2011 12:20 PM (GMT -7)   
I don't know whether or not Imuran could be contributing to the joint pain. I've never taken the medicine.

However, I do know that tapering off pred can result in joint pain. I got horrible joint pain when I tapered off of it. For the first time in my life, I got a glimpse of what it feels like to have arthritis. It was not pleasant.

The body needs time to increase its natural production of cortisol during the tapering process. The result is inflammation. The inflammation in your colon can get worse, and you might also experience inflammation elsewhere, such as in the joints.

Tapering slower should help reduce the joint pain.

NatWell
Regular Member


Date Joined Dec 2010
Total Posts : 101
   Posted 3/9/2011 1:05 PM (GMT -7)   
thanks for the input.  I do not have joint pain though.  I have a severe headache that comes on suddenly

Tigerdan
Regular Member


Date Joined Mar 2011
Total Posts : 27
   Posted 3/15/2011 11:34 AM (GMT -7)   
Here's a tip for alleviating some of the joint pain ... I have had UC for 14 years... done all the drugs ... was in remission for almost three years till I got recurring staph from a spider bite while at my kid's baseball tournament. Currently in hell tapering off prednisone again (UC under control after 5 months though). Down to 20mg from 70 mg. I go down in 2.5mg increments. This is one of the worst flareups ever. The joint pain in my legs became debilitating when I got under 30mg to the point I was unable to walk and had to crawl to get to the bathroom, or wherever. I didn't know if it was joint or muscle as my gastro said it could be proximal myopathy. Anyways - I coach a lot of sports and have tried to stay on top physical therapy trends. I was absolutley dying in pain and decided to wrap my legs and knees with tight wraps and voila, much of the pain went away. I had my wife run to the store and get a neoprene knee brace and instantly I was able to walk again, pain levels not totally gone, but down at least 70%. Then it moved to my hips, ribs, shoulders, elbows and arms. Again the wraps worked extraordinarily well in reducing the pain, that coupled with massage from my wife at least once a day. I have found that compression socks and leggings work very well for reducing the joint and muscle pain in the legs, they are not cheap, but well worth the investment. For the hips ... the old pro football player trick works well ... get some control top pantyhose a size or two too small and cut them off above the knees .. again works wonders. Shoulders are tough because you need a wide ACE bandage and have to have someone wrap it right, but again it works.

Post Edited (Tigerdan) : 3/15/2011 11:38:02 AM (GMT-6)


katm
New Member


Date Joined Jan 2012
Total Posts : 1
   Posted 1/24/2012 10:21 AM (GMT -7)   
wow ive been looking for an answer to my joint pains and stiffness, knees neck wrist and fingers, since i was on Prednisone fot 3 months not long time considering, i had enflamed lungs couldnd breath.... felt fine on the tablets apart from the weight gain and moon face , but i was told this would happen. what i wasn't told was after effects when i came of them, but doctors say this is very rare lol, well reading there threads its not that rare, think they just don't want to tell you this side effect.... its only been 5 weeks iv'e been of them, started hemp seed , evening primrose and heat patches anything so i can get joints moving, sleeping is the worst though as got to move whole body as it so sore... but still got to go to work as who will pay the bills.......

Beth75
Veteran Member


Date Joined Jul 2007
Total Posts : 2142
   Posted 1/24/2012 11:04 AM (GMT -7)   
Hi Banjonut,

I got off pred in June 2011, every time I got down to 5mg, I would have horrible joint paint, even in the soles of my feet. I could only walk down stairs one at a time (I am 36). I was also on lipitor and since being off of pred it took a few months for me to feel better, once I got off lipitor I felt even better. I have been doing strength training since Oct 2011 and it has helped me tremendously!!!!!!!!!!!!!! I am so sorry you are going through this.

All my best,
Beth
UC Pancolitis: dx'd 2000; 6th Remicade 11/25/11, next 1/19/12. Kidney Disease (Minimal Change Disease): dx'd 2007 caused by 5ASA's (thank you sulfsalazine, lialda and asacol). Current meds: Remicade & prenatal vitamin. I feel better than I have in years being off the ton of medication I was on before.

PAMtrisha
New Member


Date Joined Jan 2013
Total Posts : 1
   Posted 1/8/2013 1:13 AM (GMT -7)   
Hi, I am new here, and have been reading about the effects everyone has from Prednisone. I was on Prednisolone from Jan 2012 to end of November 2012 for Thyroid Eye disease. I started with 3 fusions of Methyl Prednisolone over three days in hospital, then 60mg tablets and gradually going down to 30mg which I stayed on for about 5 months then I weaned off over a few months stopping end of November. I suffered the usual side effects while on the pred including muscle and joint pain. I have been off the drug for 6 weeks now and I am still suffering from muscle and joint pain, sometimes I have to take Ibuprofen the pain is so bad. I have done a lot of walking, swimming and dumbell exercises during the time I was on the drug and am now doing weight training at gym. I am from a lifelong background of fitness so the exercise is part of my life. I have had all tests done to rule out any other causes and they were all negative. So it sounds obvious that I am having prednisolone side effects still. How long does this last for ? I have never had such terrible pain, at night its sometimes worse and I have noticed if I dont exercise its worse. :-(
Help and advice needed, thankyou.
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